全文获取类型
收费全文 | 12543篇 |
免费 | 1257篇 |
国内免费 | 339篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 231篇 |
妇产科学 | 175篇 |
基础医学 | 766篇 |
口腔科学 | 118篇 |
临床医学 | 1221篇 |
内科学 | 1079篇 |
皮肤病学 | 600篇 |
神经病学 | 460篇 |
特种医学 | 225篇 |
外国民族医学 | 1篇 |
外科学 | 515篇 |
综合类 | 1377篇 |
预防医学 | 1224篇 |
眼科学 | 55篇 |
药学 | 4827篇 |
51篇 | |
中国医学 | 608篇 |
肿瘤学 | 560篇 |
出版年
2024年 | 31篇 |
2023年 | 328篇 |
2022年 | 619篇 |
2021年 | 846篇 |
2020年 | 784篇 |
2019年 | 622篇 |
2018年 | 511篇 |
2017年 | 539篇 |
2016年 | 560篇 |
2015年 | 538篇 |
2014年 | 1129篇 |
2013年 | 1068篇 |
2012年 | 942篇 |
2011年 | 957篇 |
2010年 | 842篇 |
2009年 | 530篇 |
2008年 | 489篇 |
2007年 | 415篇 |
2006年 | 331篇 |
2005年 | 277篇 |
2004年 | 196篇 |
2003年 | 163篇 |
2002年 | 115篇 |
2001年 | 98篇 |
2000年 | 77篇 |
1999年 | 109篇 |
1998年 | 105篇 |
1997年 | 73篇 |
1996年 | 87篇 |
1995年 | 90篇 |
1994年 | 63篇 |
1993年 | 59篇 |
1992年 | 65篇 |
1991年 | 37篇 |
1990年 | 46篇 |
1989年 | 35篇 |
1988年 | 52篇 |
1987年 | 30篇 |
1986年 | 31篇 |
1985年 | 43篇 |
1984年 | 46篇 |
1983年 | 14篇 |
1982年 | 21篇 |
1981年 | 31篇 |
1980年 | 18篇 |
1979年 | 18篇 |
1978年 | 16篇 |
1977年 | 16篇 |
1976年 | 6篇 |
1974年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
P André 《Journal of the European Academy of Dermatology and Venereology》2004,18(4):422-425
BACKGROUND: In Europe, several filler devices are currently on the market for use in aesthetic dermatology and some of them cause severe, permanent, adverse reactions. Since 1996 a non-animal stabilized hyaluronic acid (NASHA) from Q-Medical, Sweden, has been introduced and is becoming a leading product in aesthetic dermatology. Hyaluronic acid has no species specificity and skin testing is not recommended before treatment. OBJECTIVE: Our purpose was to evaluate the incidence of adverse reactions from 1997 to 2001 and the safety of NASHA after injections into the skin for aesthetic reasons. METHOD: Surveys were sent to physicians in European countries that agreed to participate. This is a retrospective study. A total of 12 344 syringes were sold by the Q-Medical to these physicians and we evaluated the total number of patients treated to 35% of this number (4320). We separated immediate hypersensitivity reactions from delayed reactions and analysed infectious and other types of reactions. RESULTS: From 1997 until 2001, 34 cases of hypersensitivity were reported: 16 cases of immediate hypersensitivity and 18 cases of delayed. The global risk of sensitivity is 0.8%. Since 2000, the amount of protein in the raw product has decreased and the incidence of hypersensitivity reactions is around 0.6%. As 50% of these reactions are immediate and resolved within less than 3 weeks, the risk of strong but transient, delayed reaction is around 0.3%. Four cases of abscess were reported. They were all sterile. No bacterial infection was found. Herpetic recurrence is possible after lip augmentation according to the technique of injection. No systemic reactions were reported. CONCLUSION: NASHA is a very useful and safe filler product. Skin testing does not seem to be necessary. 相似文献
43.
韩巧云 《实用医学影像杂志》2007,8(2):135-136
目的探讨欧乃影在临床应用中不良反应的发生和预防措施。方法观察2003年10月至2006年7月所作1000例增强扫描者静脉注射欧乃影0.2mL/kg(其量浓度(c)为0.5mol/L)后,不良反应发生的情况。结果1000例患者中,出现不良反应6例,其中,非过敏反应3例,轻度过敏反应3例,无中度及重度过敏反应。结论欧乃影在磁共振增强扫描中不良反应发生率低,临床应用安全。 相似文献
44.
45.
M. Sibille N. Deigat V. Olagnier D. Vital Durand R. Levrat 《European journal of clinical pharmacology》1992,42(4):389-393
Summary All the clinical, laboratory and electrocardiographic adverse events detected during 24 Phase I studies in the same unit over a 5 y period are reported here. 430 healthy male volunteers were involved, corresponding to 5488 days of follow-up.The overall incidence of adverse events was 13.5%, with a significant difference between active drug (15.3%) and placebo (7.4%) treatments. There were 69 distinct types of adverse events. Headache was the most frequent symptom (2%). There were severe adverse events in 20 cases (0.36%), with an incidence of 20/430 per subject (4.6%). There were no deaths or life-threatening events.Although the main objective of Phase I studies is to determine the maximum dose tolerated, cause-effect relationships with adverse events are hard to establish, because of the frequency of adverse events with placebo, and because of the limited number of subjects included such studies. 相似文献
46.
We describe how adverse drug reactions (ADRs) can play an important role in pharmaceutical research and drug development. Not only do ADRs represent the risks and drawbacks associated with drugs but they can also be related to other knowledge available in pharmaceutical and medical research. We offer a model that can be used to systematically map the pathways through which ADRs can lead to innovative research. These pathways include chemical, therapeutic or pathophysiological steps that can be taken to arrive at new knowledge based on ADRs. We used the development of angiotensin-converting enzyme inhibitors, especially captopril, as a case study. The similarity between the ADR profiles of captopril and penicillamine was a starting point for further innovation. Historical analysis shows that in several instances research in the field of angiotensin-converting enzyme inhibitors has been triggered by ADRs. The model presented here might be applicable to other areas of innovative drug research. 相似文献
47.
S. R. Hesslewood D. H. Keeling 《European journal of nuclear medicine and molecular imaging》1997,24(9):1179-1182
A prospective survey was performed in 17 nuclear medicine departments during 1996 in an attempt to provide reliable data on the prevalence of adverse reactions to radiopharmaceuticals. All adverse events following radiopharmaceutical administration were recorded, irrespective of the severity or likelihood of causality, and subsequently analysed using an algorithm developed by Silberstein et al., designed to establish a cause-effect relationship. A prevalence of 11 events per 105 administrations was obtained (95% confidence limits 3.3–19.2). No serious of life-threatening events were reported. This rate is slightly higher than that obtained in a larger scale study in the United States (2.3 events per 105 administrations, 95% confidence limits 1.2–3.4). The difference may be due to the decision to include or exclude vasovagal events from the analysis, the way in which the algorithm was used and the comparative size and time scale of the two studies. The prevalence of adverse reactions is approximately 1000-fold than less that occurring with iodinated contrast media and drugs. 相似文献
48.
C. L. Goh 《Contact dermatitis》1992,27(2):84-89
This is a report on a comparative study of the reactivity of TRUE Test and Finn Chamber patch test techniques. 413 patients attending a contact dermatitis clinic in Singapore were simultaneously patch tested with panels 1 and 2 of the TRUE Test standard series and with corresponding allergens (Hermal, Hamburg) using Finn Chambers. The left/right application of the TRUE Test and Finn Chambers was randomized. The concordance of positive patch test reactions to the 2 test techniques was studied. The number of patient with positive reactions was 38% and 42% for TRUE Test and Finn Chamber techniques, respectively (n.s.). The overall concordance of positive patch test reactions was 64% (209/328). 13% (42/328) of positive reactions appeared on TRUE Test only and 24% (77/328) on Finn Chamber only. When only relevant positive reactions were considered, the concordance rate was 67%; 11.6% of positive reactions appeared on TRUE Test only and 21% on Finn Chamber only. Positive reactions to p-phenylenediamine (PPD) and neomycin were more frequent with the Finn Chamber technique than with TRUE Test, i.e., false negative reactions to PPD and neomycin were more likely to occur with TRUE Test. It appeared that the TRUE Test and Finn Chamber techniques were comparable when used for patch testing. However false negative and false positive patch test reactions can occur when using either technique. 相似文献
49.
Eugenija Zuskin E. Neil Schachter Bozica Kanceljak Jadranka Mustajbegovic Theodor J. Witek 《International archives of occupational and environmental health》1994,66(5):317-324
The relationship of skin reactivity and serum immunoglobulin E (IgE) levels to the prevalence of chronic respiratory symptoms and to ventilatory capacity is examined in workers exposed to different organic aerosols. The results from group of control workers similarly tested are also presented. Workers exposed to occupational allergens had positive skin tests more frequently than did controls, except for soy bean workers. Workers with positive skin tests to occupational allergens had a higher prevalence of almost all symptoms than those with negative skin tests although the differences did not always reach statistical significance. Workers with positive skin reactions in general had significantly higher serum IgE levels than did workers with negative skin reactions. There were across-shift reductions of ventilatory capacity in all groups of exposed workers, varying for forced vital capacity from 1.7% to 13.3%, for forced expiratory volume from 0.4%–21.9%, for maximum flow rates at 50% from 1.5% to 16.1% and for maximum flow rates at the last 25% of control vital capacity from 0% to 24.9%. There was, however, no correlation between acute and chronic lung function changes and skin reactivity or IgE values. Our data suggest that although exposure to organic aerosols may be associated with frequent immunologic reactions, these findings do not predict objective respiratory impairment.The research was supported in part by grant no. JBP 733 from the National Institutes of Health, Bethesda, Md., USA, and by grant no. RO1 OHO-2593-04 from the National Institutes of Occupational Safety and Health, Centers for Disease Control, Atlanta, Ga., USA 相似文献
50.