复方18甲基炔诺酮透皮控释传递系统的LNG人体药物动力学与药效学评价

复方18甲基炔诺酮/雌二醇透皮控释传递系统(LNG/E_2 TCDS)能同时恒速释放低剂量的LNG和E_2,在1周内维持一个平稳而有效的LNG血药浓度。药动学与药效学研究证明,该系统释放的LNG能达到血清LNG目标水平,产生有效的排卵抑制(6/6)。LNG/E_2 TCDS可望发展成为一种安全、有效、非侵入性的新型生育调节避孕制剂。     

18F-FDG PET显像在发热待查患者中筛查淋巴瘤的价值

目的　探讨18F 脱氧葡萄糖 (FDG)PET显像在长期发热患者中筛查淋巴瘤的价值。方法　对 5 9例长期发热患者 (发热持续时间至少 3周 ,测 3次体温超过 38 3℃ )的18F FDGPET显像资料进行回顾性分析 ,将18F FDGPET显像诊断结果与病理检查及随访结果进行比较。结果　 5 9例长期发热患者中有 8例PET显像示恶性淋巴瘤可能 ,最后均经病理检查确诊为淋巴瘤 ,其中 2例为霍奇金淋巴瘤 ,6例为非霍奇金淋巴瘤。结论　PET显像示长期发热的淋巴瘤患者其病变淋巴结可在正常范围内 (<1 0cm或在体内较深部位 )。对长期发热患者 ,18F FDGPET显像可初步筛查淋巴瘤及排除其他肿瘤 ,可为穿刺活组织检查提供定位信息。     

18F-FDG PET显像在原发性肝癌中的应用价值

原发性肝癌是我国常见的恶性肿瘤之一，在男性占第3位，女性占第4位，近年世界各地肝癌发病率都有上升趋势，肝细胞癌（HCC）是其中最常见的一种细胞类型，其次为胆管细胞癌（CCC）等。原发性肝癌起病隐匿，出现临床症状时往往已到晚期，影像学检查是其早期诊断的重要手段。PET作为一种先进的功能影像学设备，在其诊疗中的应用越来越广涉。     

白细胞介素-18在特发性血小板减少性紫癜中作用的研究

目的 探讨白细胞介素-18(IL-18)与特发性血小板减少性紫癜(ITP)发病的关系,研究其在ITP发病中的作用及临床意义.方法 酶联免疫吸附测定(ELISA)测定血浆IL-18,对36例ITP患者和正常对照组血浆IL-18的水平进行分析.结果 ITP组血浆IL-18含量为(538.31±111.33)pg/ml,正常对照组血浆IL-18含量为(489.44±49.07)pg/ml.IL-18含量与血小板数量呈显著性负相关(r=-0.395,P＜0.05).结论 ITP发病时患者血浆中的IL-18水平比正常对照组明显升高,IL-18与ITP发病密切相关.     

免疫缺陷性皮肤病

20072226HIV-1Tat蛋白促血管生成作用研究进展(综述)/陆丛笑(中国海洋大学医药学院),李静,耿美玉∥中国皮肤性病学杂志.-2007,21(4).-239~241,254Tat蛋白是HIV-1基因组编码的6个调控蛋白中的一个重要调控蛋白,在艾滋病相关卡波西肉瘤的发生发展中起一定作用。从Tat蛋白结构特点     

18F-FDG hPET/CT显像诊断结直肠癌术后复发转移

目的 评价^18F-FDG hPET／CT代谢显像对结直肠癌患者术后复发转移的诊断价值。方法 对81例结直肠癌术后临床可疑肿瘤复发或转移的患者采用GEHAWKEYE符合线路SPECT进行^18F-FDG显像，获得经X线衰减校正后的三维断层图像，由计算机完成各断层图像的融合，以目测法进行诊断分析，并与CT、病理学检查、临床随访作出的最后诊断进行对比。结果 ^18F-FDG hPET／CT代谢显像对结直肠癌术后复发、转移诊断的灵敏度为93％（57／61），特异性为80％（16／20），阳性预测率为93％（57／61），阴性预测率为80％（16／20）；而常规CT对结直肠癌术后复发转移诊断的灵敏度、特异性、阳性预测值、阴性预测值分别为67％（37／55）、73％（19／26）、84％（37／44）、51％（19／37）；^18F-FDG hPET／CT代谢显像共检出病灶126个，65例相同视野hPET／CT代谢显像与诊断CT常规影像检查复发转移病灶检出数分别为91个和46个。结论 ^18F-FDG hPET／CT显像对结直肠癌术后复发转移的诊断价值优于CT；通过与同机定位CT图像融合可有效地对病变进行定性定位。     

Effect of electro-acupuncture combined with early rehabilitation on motor function and expressions of CD11b/CD18 and tumor necrosis factor-α in patients with acute cerebral infarction

Objective To observe the effect of electro-acupuncture combined with early rehabilitation on the motor function and expressions of the adhesion molecules CD11b and CD18 in the polymorphonuclear leucocytes (PMN) and monocytes and serum tumor necrosis factor-α (TNF-α) levels in patients with acute cerebral infarction (ACI). Methods A total of 165 ACI patients were randomly divided into control group (group A, n=50), conventional rehabilitation group (group B, n=50) and comprehensive rehabilitation group (group C, n=65). The expressions of CD11b and CD18 in the PMN and monocytes and serum TNF-α levels were determined before and at 1, 2, and 4 weeks after the treatment. Thirty-two healthy subjects were also recruited as the normal control group (group N). The neurological function of the subjects was evaluated by modified Edinburgh-Scandinavia stroke scale (MESSS) and Fugi-Meyer Assessment (FMA), and their activity of daily living (ADL) was assessed using Barthel index (BI). Results The CD11b/CD18 expression in the PMN and MN and serum TNF-α level in groups A, B and C were significantly higher than those in group N before and 1 week after the treatment (P<0.05). CD11b/CD18 expression and serum TNF-α level were significantly lower in groups B and C than in the group A at 1 week after the treatment, and significantly lower in group C than in group B (P<0.05). At 2 weeks of treatment, CD11b/CD18 and TNF-α were significantly lower in groups B and C than in the group A, being the lowest in group C (P<0.05). The scores of mESSS in both groups B and C were lower than that in group A, and the scores were lower in group C than in group B. Group C showed higher FMA scores than group B, both having higher scores than group A. At 4 weeks of treatment, the mESSS scores were significantly lower, hut the FMA and ADL score significantly higher in groups B and C than in the control group (P<0.05), and the differences were more obvious in group C. Groups B and C had greater effective rate than group A (P<0.05), and the rate was the highest in group C (P<0.05). Conclusion Electro-acupuncture combined with early rehabilitation promotes the recovery of motor function in ACI patients probably by regulating the expressions of the adhesion molecules CD11b and CD18 on the PMN and monocytes and the serum levels of TNF-α.