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991.
ObjectiveA systematic review was conducted to investigate the efficacy of Guilu Erxian Jiao (GEJ) in the treatment of knee osteoarthritis (OA).MethodsWe searched PubMed, MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese Electronic Periodical Services, and ClinicalTrials.gov to identify relevant randomized controlled trials or controlled clinical trials, from the inception of each source to April 20, 2021. Primary outcome included overall efficacy, pain score, and Lequesne index score; secondary outcome included adverse events. Methodological quality was assessed using the Cochrane risk of bias tool (RoB 1.0). The meta-analysis was performed based on a random-effects model due to anticipated clinical heterogeneity. The grading of overall evidence was assessed using the GRADE system. The study protocol was registered on PROSPERO (CRD42021233573).ResultsEight studies were included. Compared to controls, GEJ exhibited superior overall efficacy for treating OA (risk ratio (RR) = 1.20; 95% confidence interval (CI) = 1.06–1.35). Regarding pain score, there was no statistical difference between GEJ and controls (standardized mean difference (SMD) = 0.27; 95% CI = −0.91 – 1.46). No significant difference was found in Lequesne score between GEJ and controls (MD = −0.25; 95% CI = −0.52 – 0.01). No statistical difference in adverse reactions was observed between GEJ and controls (risk difference (RD) = −0.01; 95% CI = −0.05–0.03).ConclusionOur findings suggest that GEJ may have positive effects on overall efficacy in treating OA. However, there is insufficient evidence regarding pain score, Lequesne score, and knee joint function score. 相似文献
992.
BackgroundMindfulness interventions can improve psychological distress and quality of life (QoL) in cancer survivors. Few mindfulness programs for cancer recovery exist in Southeastern U.S. The primary objective of this study was to assess the feasibility of a modified mindfulness-based stress reduction (MBSR) program for breast cancer patients in Birmingham, Alabama. The secondary objective was to explore potential program effects on mindfulness skills and QoL.MethodsThis study was a prospective, quasi-experimental feasibility study conducted over 10 months at a university hospital. Feasibility was achieved if 80% of eligible patients screened enrolled in the study and 70% of enrolled patients attended all 8 program sessions. Effectiveness was estimated by changes in mindfulness and QoL indicators measured with validated scales administered at 3 time points and assessed with a non-parametric Friedman test. Sessions included meditation, yoga, and an attention practice called body scan. There were 3 groups of 2–5 patients.ResultsThe sample totaled 12 patients. Forty-four percent (12/27) of eligible patients enrolled in the study, and two out of 12 enrolled patients completed 8 program sessions, resulting in 16.7% (2/12) retention. However, more than half (66.7%) of participants completed at least 7 sessions. Between baseline and 8-week follow-up, patients demonstrated statistically significant improvements in distress, general wellbeing, and fatigue-related QoL.ConclusionsFeasibility objectives were not achieved. However, a majority of participants (66.7%) completed 7 of 8 program sessions. Program effects were promising for distress, fatigue, and wellbeing. Results warrant further research on MBSR-like programs for breast cancer patients in Alabama. 相似文献
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995.
慢性肾功能衰竭中医证型标准化研究探讨 总被引:21,自引:0,他引:21
本文对2次全国性慢性肾衰中医辨证分型标准进行了分析和总结,并按现行慢性肾衰辨证分型方案对444例患者进行证候学研究,列出了慢性肾衰中出现率高且具有鉴别诊断价值的症状及体征,并发现慢性肾衰尿毒症患者其气血阴阳虚损的积分值明显高于其它各期,提出现行方案的不足之处及有待改进的探讨意见 相似文献
996.
慢性咽炎动物模型研究 总被引:19,自引:1,他引:18
为探索慢性咽炎动物模型的复制以供实验研究之用,根据慢性咽炎的临床诊断标准用氨水在咽部喷雾和松节油在其粘膜下注射的方法研制慢性咽炎的动物模型,并从症状体征,血液学,组织学及超微结构等方面进行了观察。 相似文献
997.
应激反应对心肌缺血再灌注损伤的影响 总被引:1,自引:0,他引:1
探讨应激反应对心肌缺血再灌注损伤的保护作用及其机制。方法:按改良的Kane方法,制备 心肌缺血再灌注损伤模型。观察结扎左冠状动脉前、后的 1、5、10min及再灌注10min内心功能指标及再灌注期 间的室速(VT)、室颤(VF)发生率及动物死亡率(M),并测定心肌丙二醛(MDA)含量及超氧化物歧化酶(SOD)的活 性与对照组比较。结果:实验组的心功能明显的得到了改善;VT、VF及M均明显降低;心肌内MDA含量明显减 少,而SOD的活性则明显增加.结论:应激反应具有抗心肌缺血再灌注损伤作用,主要作用机制与其增强心肌内 源性抗氧化能力有关。 相似文献
998.
目的:探讨肺心病患者的心电图改变。方法:对196例肺心病患者的心电图进行分析。结果:196例中心电图异常者187例,达总数的954%,其中PtfV1异常者达163%。结论:肺心病可产生多种心电图异常,其中肺心病PtfV1异常应引起重视。 相似文献
999.
材料力学性能对人颞下颌关节力三维非线性模拟的影响 总被引:5,自引:0,他引:5
比较分析骨性结构和关节盘的材料力学性能对在活性基础上建立的人颞下颌关节(Temporo-mandibularjoint,TMJ)三维非线性有限元模型模拟TMJ力的影响。方法利用Auto-CAD软件及螺旋CT扫描技术与有限元应力分析方法的相结合在活性基础上建立TMJ三维非线性有元模拟型并比较下颌骨,关节窝和关节盘选用不同材料力学性能时关节内应力的变化。结果骨组织的各种向同性和各向异性特征使组成TMJ 相似文献
1000.
目的:探讨使用大剂量干扰素(IFNα)治疗慢性丙型肝炎(CAH)的效果。方法:使用大剂量IFNα,每天600万U,连续投药3周,以后每周3次间断投药21周,共计24周,治疗CAH50例。观察治疗前后血清HCVRNA与ALT的变化,以此作为IFN疗效的判定指标。结果:IFN治疗CAH有效率为68%,停药6个月后有34%复发。结论:IFN的疗效与CAH的基因亚型有关(Ⅲ型疗效显著,Ⅱ型较差),与IFN的剂量无明显关系。 相似文献