Preventive effect of hydrotalcite on gastric mucosal injury in rats induced by taurocholate

AIM: To study the preventive effect of hydrotalcite on gastric mucosal injury in rat induced by taurocholate, and to investigate the relationship between the protective mechanism of hydrotalcite and the expression of trefoil factor family 2 (TFF2) mRNA and c-fos protein.METHODS: Forty five male Wistar rats were randomly divided into hydrotalcite group, ranitidine group and control group. Gastric mucosal injury was induced by introgastric acidified taurocholate. OD value of TFF2 mRNA expression in gastric mucous cells was determined by hybridization and computer image analysis system. OD value of c-fos protein expression in gastric mucous cells was measured by immunohistochemistry and computer image analysis system.RESULTS: The gross mucosal injury index in hydrotalcite group was significantly lower than that in ranitidine group and control group (8.60±2.20 vs 16.32±4.27, 29.53±5.39;P＜0.05, P＜0.01). The expression level of TFF2 mRNA in hydrotalcite group was markedly higher than that in ranitidine group and control group (0.56±0.09 vs 0.30±0.05, 0.28±0.03,P＜0.05). The OD value of c-fos protein in hydrotalcite group was higher than that in ranitidine group and control group (0.52±0.07 vs 0.31±0.04, 0.32±0.05, P＜0.05).CONCLUSION: Hydrotalcite can protect gastric mucosal injury in rats induced by taurocholate, which may be related to the increased expression of TFF2 and c-fos protein.     

三石三金排石汤治疗泌尿系统结石60例

笔者从１９９０年以来应用自拟三石三金汤治疗泌尿系统结石收效甚佳，报道如下。１临床资料 本组６０例中，男３４例，女２６例；年龄最小１８岁，最大６０岁。全部病例均经彩超检查证实。其中肾结石２２例，输尿管结石３０例，膀胱结石８例，合并肾盂积水１２例；结石最大 １．１ｃｍ ×１．０ｃｍ，最小 ０．４ｃｍ ×０． ３０ｃｍ。２治疗方法 自拟三石三金排石汤组成：鱼脑石１５ｇ，滑石２０ｇ，石韦１５ｇ，金钱草３０ｇ，海金沙３０ｇ，鸡内金２０ｇ，厚朴１５ｇ，赤芍 １５ｇ，牛膝 １２ｇ，熟地 ２０ｇ，王不留行 ２０ｇ，车前子…     

自拟“滑石十草汤”治疗热淋证32例疗效观察

淋症是临床常见病,多发病,是指小便频数短涩、滴沥刺痛、欲出未尽、小腹拘急或痛引腰腹的病症.淋证之病名首见于内经,其病位主要在膀胱和肾.现代临床沿用五淋之名,分为热淋、血淋、膏淋、石淋、劳淋;但以热淋最为临床常见和频发.现代医学的急性膀胱炎、尿道炎、急性肾盂肾炎、慢性肾盂肾炎急性发作等均属淋证中的"热淋"范畴.     

石棉诱发胸膜病变的X线征象

自然界有100多种矿物呈纤维状结构,能引起胸膜病理反应的有石棉、沸石、滑石、云母,以石棉纤维最多见。当纤维直径<0.2μm,长>3～5μm时,具有高度危害性。引起机体病理改变还必须吸入足够的量,在组织中贮留足够的时间,大量流行病学调查和     

滑石组方变化浅析

中国医药学将滑石作为药物,已有二千余年的历史,东汉末年的医学专著《神农本草经》已将滑石收入,论其疗效“主身热泄辟,女子乳难、癃闭、利小便,荡胃中积聚寒热”，明代李时珍《本草纲目》论滑石能“疗黄疸、脚气、吐血、呕血、金疮出血、诸疮肿毒”。     

中医药治疗痛风病举隅

例1,患者,男,28岁,1997年10月14日初诊.主诉:右拇指红肿疼痛1周.现病史:右拇指红肿疼痛,伴灼热感,口干口渴,面红目赤,心烦易怒,大便干,2日一行,舌质红苔黄腻,脉滑数;实验室检查:血尿酸512mmol/L.中医辨证:湿热痹阻经络.立法:化湿清热,通络活络.方药:生薏苡仁30g,金银藤30g,佩兰12g,藿香12g,蒲公英30g,白蔻仁9g,连翘15g,黄芩12g,丝瓜络12g,白通草9g,滑石30g,甘草6g.     

水滑石类层柱材料作为新型药物载体的研究进展

目的介绍水滑石类层柱状材料作为新型药物载体在医药领域中的应用。方法通过查阅国内外相关文献,以其中的30篇文献为依据,阐明水滑石载药的机理和影响因素,对其在医药领域中的应用进行归纳、总结。结果和结论虽然水滑石类层柱状材料的应用迄今为止多数仍停留在初级研究阶段,但可以预见该类无机材料在医药领域中的应用会显现出更大的优势。