Endoscopic therapy of weight regain after bariatric surgery

Weight regain following primary bariatric surgery occurs in a significant proportion of patients and is attributed to epidemiological, anatomical and metabolic factors. Surgical revision of these patients has significant risks and limited benefits. Endoscopic revisions that reduce gastric pouch size and diameter of the gastrojejunal anastomosis may offer an effective, safe, less invasive and even reproducible treatment. We herein discuss the indication, selection and feasibility of different endoscopic techniques that could be used in the management of weight regain following primary bariatric surgery. Future research could optimize a personalized approach not only in the endoscopic management but also in combination with other therapeutic modalities for weight regain after bariatric surgery.     

Progress of laser and light treatments for lower eyelid rejuvenation

Laser and light treatments have recently become popular owing to its efficacy in treating laxity, rhytids, hyperpigmentation of the lower eyelids, and drooping of septum fat. For several decades, our department has explored the application of laser and light treatment for eye rejuvenation. This paper summarizes common treatment methods and analyzes the published literature on the indications and outcomes of multiple laser and light treatments for lower eyelid rejuvenation. An extensive survey of peer-reviewed literature was performed using PubMed, with the search terms “noninvasive treatment”, “infraorbital”, “palpebral bags”, “lower eyelid”, “radiofrequency (RF)”, “laser”, “nonsurgical skin tightening”, and “noninvasive fat reduction”. The results showed that the use of lasers, intense pulsed light (IPL), monopolar RF, bipolar RF, AdipoLASER rejuvenation (ALJ), and fractional RF microneedling are safe and effective treatments for palpebral bags. We conclude that using Q-switched lasers, IPL, RF, ALJ, and fractional RF microneedling is safe and effective for lower eyelid rejuvenation, with minimal complications and quick recovery. Further research and development of optoelectronic therapy may encourage breakthroughs in lower eyelid treatment, such as simplified complex surgery and noninvasive methods.     

常用炮制对滇产草乌3种乌头碱减毒情况分析

目的 利用几种常规的炮制方法分析草乌中乌头碱、次乌头碱和新乌头碱的减毒情况。方法 将大小形状不同的草乌样品分别经过水煮法、蒸法及烘烤法进行不同时长炮制,采用超高效液相色谱串联质谱进行含量测定分析,外标法定量。结果 3种乌头碱在0.20～100.0μg/L浓度范围内均具有良好的线性关系,相关系数均大于0.9997。草乌不同形状减毒效果为粉末＞片状＞完整个头,不同炮制方法减毒效果为水煮＞蒸＞烘烤,烘烤炮制对草乌样品未有良好减毒效果。浓度为1.0μg/mL的乌头碱、新乌头碱和次乌头碱标准品分别经过0.5h、1.5h和1.5h水煮炮制可达到100%完全降解,但其他炮制样品的减毒效果根据不同的炮制方法显现出较大差异性。结论 3种乌头碱经过足够时长的水煮及蒸法炮制均可达到显著的减毒效果,烘烤法对草乌减毒作用较小,民间食用草乌的安全性应引起高度重视。     

人工神经网络预滤波的自适应运动心电信号增强器

运动心电图是一种将人体对象置于非平静状态下检测到的心电信号，其特点是运动导致基线严重漂移，肌电干扰显著增加，信噪比低。介绍了一种用人工神经网络预滤波的自适应运动心电信号增强器。运用人工神经网络的非线性和自适应处理的跟踪特性有机地结合设计而成。能降低噪声，提高信噪比，有效地提取运动心电信号。     

糖尿病大鼠肾脏抗氧化防御机能的变化

目的：探讨糖尿病对肾脏抗氧化防御机能的影响。方法：观察12周糖尿病大鼠肾皮质丙二醛（MDA）及谷胱甘肽（GSH）水平,以及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH－PX）、谷胱甘肽S－转移酶（GSH－ST）和过氧化氢酶（CAT）活性的变化。结果：糖尿病大鼠肾组织中SOD、GSH－ST及CAT活性下降,GSH含量显降低;MDA没有变化;GSH－PX活性却明显增强。结论：糖尿病大鼠肾组织抗氧化防御机能明显下降。     

表皮生长因子对人子宫颈癌细胞形态及噻唑蓝还原的影响

表皮生长因子(EGF)10μg/L作用于人子宫颈癌(Hela)细胞,24h、48h未见细胞数量改变,第5d时可观察到细胞由原来的呈椭圆形克隆样生长变为有树突样胞质突出的长梭状较均匀地分布生长:EGF作用下,Hela细胞噻唑蓝还原呈剂量依赖性增加.提示EGF不能促进Hela细胞增殖,但可引起细胞形态改变及线粒体脱氢酶活性增高,这可能与EGF促分化作用有关.     

颌骨骨折465例治疗体会

目的总结五年颌骨骨折治疗体会,探讨有关问题.方法选用1995年3月至2000年3月治疗的颌骨骨折465例,男348例、女117例.根据就诊时间早晚、致伤原因、骨折部位及分类,治疗方法选择进行总结.结果治疗有效率98.92%,行紧急气管切开术45例,抗体克12例,手术切开复位骨间固定284例,手法或牵引复位外固定181例,术后感染骨延迟愈合8例(1.7%)合并颅脑损伤死亡5例(1.08%).结论①排除颅脑及内脏损伤,保证无窒息、休克发生,通过临床表现确诊骨折类型.②要使骨折片尽早复位,应用坚固内固定技术保证骨块不再移位,恢复伤前咬合关系,软组织要严密缝合.③正确地运用正颌外科技术,使陈旧性骨折达到三维立体方向复位.     

中医药对肿瘤化疗减毒作用的研究进展

从化疗常见毒副反应及中医辨证分型,化疗毒副反应的治疗原则,以及中医药减毒作用的临床研究与实验研究几个方面,对近年来中医药在肿瘤化疗中减毒作用的文献报道进行综述。无论是临床观察,还是实验研究,均证明中医药对化疗药物有确切的减毒作用,对肿瘤病人化疗的顺利完成,起到了积极的作用。     

手性修饰的硼氢化钠对前手性酮的不对称还原

研究了以Ｎ－苄基－（３Ｓ,４Ｓ）－３,４－二羟基四氢吡咯修饰的硼氢化钠对前手性酮的不对称还原反应,合成了五个光学活性醇,同时研究了添加路易斯酸对还原反应光学产率的影响。     

慢性阻塞性肺病胸腔镜肺减容手术的治疗观察

目的 评价胸腔镜肺减容手术对重度慢性肺病的治疗疗效和病情改善情况。方法 对我院１０例重度慢性阻塞性肺病患者行肺减容手术后随访１年半观察,同时与１０例未做手术的重度ＣＯＰＤ患者比较,比较其在入院次数,肺功能改善情况（自行上楼比较）、吸氧时间、生活自理能力等方面的差异。结果 手术组病人因慢性支气管炎急性发作、肺部感染再次入院次数明显减少,自行上楼气急明显比手术前减轻,吸氧时间明显减少,、生活自理能力增