皮肤组织热水烫伤传热分析

目的：研究生物组织热水烫伤过程的传热规律及影响因素并由此进行烫伤程度预测。方法：基于Pennes生物传热方程，建立热水洒落皮肤组织所致烫伤过程的一般模型，研究生物组织内部的温度变化规律，并对生物组织烫伤程度进行预测。结果：通过数值计算，得到生物组织内部的温度分布，以及生物组织烫伤发生的开始时间。研究表明，皮肤及内部组织初始温度分布、热水与皮肤表面的对流换热系数及热水的温度对于烫伤的发生有显著影响。结果：该模型可用于生物组织热水烫伤过程传热分析和烫伤预测，为烫伤的诊断和治疗提供依据。     

Protein kinase C agonist and antagonist effects in normal human epidermal keratinocytes

Abstract Several lines of evidence implicate protein kinase C (PKC) in the development of basal cell and squamous cell carcinomas, tumors which originate from epidermal keratinocytes. To examine PKC in a model relevant to human skin, we exposed normal human epidermal keratinocytes (NHEK) in serum-free media to a variety of PKC agonists and antagonists. NHEK PKC activity increased up to 10-fold within the 1st hour of exposure to tetradecanoyl phorbol acetate (TPA), and gradually returned to control values within 72 h. TPA-induced PKC activity was enhanced by pretreatment of cultures with protein and RNA synthesis inhibitors. TPA-induced growth arrest and differentiation was antagonized by staurosporine. Down-regulation by bryostatin pretreatment blocked TPA-stimulated differentiation. Our overall conclusion is that activation of PKC in cultured human keratinocytes is required for differentiation. These results are crucial to the analysis of compounds suspected of promoting or inhibiting epidermal tumors.     

Ambulatory monitoring of ultraviolet erythema in photosensitive subjects

Little is known about whether patients with photosensitive disorders exhibit a different ultraviolet erythema time course from subjects with a normal response to sunlight. We have described the application of an instrument for ambulatory monitoring of the development of ultraviolet erythema by a reflectance method in a group of patients with chronic actinic dermatitis (CAD) and in a group of normal subjects. Investigations of the time course have been reported previously but the techniques used relied upon manual measurement. Consequently sampling frequencies have been considerably lower than the one-minute sample rate used here. We have not demonstrated any difference in the rate at which erythema develops and peaks between patients with CAD and subjects with a normal response to sunlight.     

面部色素痣的外科治疗

面部色素痣较常见于鼻、颊、额、颧区，部分病变累及一侧面部的多个区域。这些病变手术切除后的缺损主要采用全厚皮片移植、直接拉拢缝合或邻近皮瓣整复。     

皮肤软组织扩张器在整形外科中的应用

作者应用皮肤软组织扩张器进行软组织缺损修复１３例，全鼻再造１例，除１例皮瓣远端血运不佳外，其余病例均获满意效果。本文介绍了皮肤软组织扩张术的优点及适应症，重点讨论了下列问题：①皮肤扩张面积的估计；②扩张囊埋植层次；③注射壶、连接导管的安放位置；④纤维囊的处理；⑤扩张皮瓣的正确设计。     

第一掌背动脉双叶皮瓣在手外科中的应用

我们设计主要以第1掌背动脉为蒂的手背双叶皮瓣,同时修复两个部位的手部皮肤缺损和拇指再造,共10例均获成功。皮瓣面积最小10cm×3cm,最大13cm×5cm,蒂宽1.5cm×2.5cm。皮瓣每叶面积最小为3.5cm×2cm,最大6cm×3cm。文中介绍了本皮瓣的解剖学基础,并对其手术适应证和优缺点进行了讨论。     

面癣的临床与真菌学研究

采用临床观察，真菌镜检及真菌培养的方法，对９０例面癣患者进行了系统研究。结果显 示，自然过程面癣患者皮损为典型的体癣样损害，用药病例则呈非典型表现，此与外用皮质激素密 切相关。皮损真菌镜检阳性率为１００％，典型损害与非典型损害间阳性率无显著性差别（Ｐ＞０．０５）， 真菌培养石膏样毛癣菌占７８．８％，红色毛癣菌占１３．３％，其它７．７％。结果表明；面癣的临床和真菌 学特征与体癣相同，其诊断和治疗应与体癣标准一致。     

真皮下血管网皮瓣的过氧化脂质测定

对12只豚鼠背部随意型真皮下血管网皮瓣的过氧化脂质含量进行了动态观测.结果表明,过氧化脂质的含量与皮瓣损伤程度呈同步变化;与皮瓣血运重建的时间密切相关.氧自由基对皮瓣组织的损伤主要发生在移植后1～5天.     

面部瘢痕整形手术后胶布减张治疗疗效观察

目的:探讨使用免缝胶布对伤口减张制动的方法和治疗效果。方法:对62例面部瘢痕或痣切除手术患者,随机分组,45例为治疗组,术后5天拆线,拆线当天开始使用免缝胶布。胶布垂直跨越伤口线粘贴,使创缘处于无张力状态。17例为对照组,未使用免缝胶布。术后6个月对瘢痕进行临床评分,治疗组与对照组对比,统计分析。结果:62例患者伤口均一期愈合,治疗组37位(82%)、对照组4位(23%)患者瘢痕恢复至成熟期,没有痒或刺痛的主观症状,瘢痕颜色淡、平坦、质地软;治疗组5位(11.1%)、对照组13位(76.5%)患者瘢痕增宽,有痒或刺痛的症状,瘢痕颜色红,突出皮面。结论:免缝胶布可以有效地减轻伤口两侧张力,减少瘢痕增生,是一种瘢痕术后重要的辅助治疗。