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71.
Doug Joshua Max Wolf Jane Matthews Lee Tan William Sheridan Glenn Pilkingtonh Fiona Page 《Leukemia & lymphoma》1994,14(3):303-309
The Australian Leukaemia Study Group myeloma study (MM1) aimed to determine the prognostic significance of clinical and immunophenotypic markers in patients with multiple myeloma. All patients were treated with standard dose melphalan and prednisone. Seventy-four patients were entered and the median survival was 27 months. Serum beta 2-microglobulin (βM) and albumin levels were the only significant clinical factors influencing survival (p = 0.007 and p = 0.008, respectively). Patients with raised levels of CD38+ lymphocytes at presentation had a significantly shorter survival than patients with normal levels (p = 0.01, logrank test, median 19 months vs 33 months). CD38 antigen expression was independent of β2M but patients with raised levels of CD38 had significantly lower levels of albumin than patients with normal levels (p = 0.001) which may explain their poorer survival. Salmon and Durie stage was not associated with antigen expression. No other B-cell antigens (CD10, CD19, CD20, CD21, CD22, CD23, FMC1 or FMC7) or plasma cell antigens tested (PCA-1) were found to be associated with prognosis. Patients who achieved plateau phase had a better prognosis than those who did not (p = 0.04 in a landmark analysis). Patients who achieved plateau phase following an objective response appeared to have a better prognosis than those who were in plateau phase at presentation (p = 0.09 in a landmark analysis). Light chain isotype suppression (LCIS) was not associated with a significant survival advantage and did not correlate with any known prognostic indicator. We conclude that phenotypic analysis of peripheral blood lymphocytes for CD38 antigen at diagnosis may be useful as a prognostic indicator in patients with myeloma. 相似文献
72.
顺铂、氟脲嘧啶、潘生丁(DFP)联合化疗治疗晚期食管癌—附125例不同给药剂量疗效分析 总被引:2,自引:0,他引:2
采用不同剂量DFP(DDP-5-FU-PST)联合化疗,随机分4组治疗晚期食管癌125例,CR18例,PR55例,MR26例,S12例,P14例,缓解率(CR+PR)58.4%(73/125例),总有效率(CR+PR+MR)79.2%(99/125例)。不同给药剂量疗效有所差别,以DDP分次剂量30~50mg/m~2,总剂量420~450mg;5-FU分次剂量750mg/m~2。总剂量15g疗效较好,缓解率60~83.33%。中数生存时间7.8月,1年生存率16%(20/125例)。108例(86.4%)有厌食、恶心、呕吐,24例(19.2%)白细胞和血小板减少,2例在用5-FU时出现心脏毒性,无肝肾功能损害。 相似文献
73.
光动力学疗法与局部化疗联合治疗进展期食管贲门癌 总被引:2,自引:0,他引:2
作应用光动力学疗法(PDT)对进展期食管贲门癌55例进行治疗,并对其中15例联合应用内镜下局部注射抗癌药物。对每一患均先静脉滴注血卟啉衍生物(HPD)5mg/kg,于用药后24,48和72h分别用波长630nm的铜蒸汽激光照射肿瘤部位。联合治疗组除PDT治疗外,于每次光照前肿瘤局部注射5-Fu250~500mg。结果:联合治疗组的近期显效率高于单纯PDT组(P〈0.05)。病例随访6~16月, 相似文献
74.
78例胃窦癌的治疗分析 总被引:1,自引:0,他引:1
自1988年2月至1992年8月期间手术治疗的78例胃窦癌患者进行了回顾性分析,手术后肿瘤复发的情况,与十二指肠断端有无癌细胞残存密切相关,并发现于幽门环下切断十二指肠少于3cm者有癌细胞残存达34%,切除十二指肠达3cm者,无论肿瘤分化程度如何,恶性程度高低,切除断端均无癌细胞残存,手术后辅以化疗,对于病人的预后有一定提高。本组随访到的59例病人中,接受化疗的33例,在2年3个月至6年1个月内死亡7例(21.2%),未接受化疗的26例,在5个月至3年8个月内死亡的26例,在5个月至3年8个月内死亡9例(35%)。 相似文献
75.
A. Parthasarathy N. Sumathi R. Manoharan C. D. Natarajan R. Narmada B. R. Santhanakrishnan 《Indian journal of pediatrics》1987,54(5):779-784
Tuberculous infection among children continues to be a significant cause of morbidity. The symptom complex are so variable
among children that the final diagnosis often rests on the laboratory tests. Proper interpretation of the tests, specially
tuberculin test and radiographic studies, are necessary for establishing correct diagnosis. The usefulness of tuberculin test
in both unimmunized and BCG vaccinated children is highlighted. BCG accelerated response as a test should be reserved for
identifying serious form of pulmonary disease or CNS tuberculosis when the tuberculin test is negative. Radiographic assessment
may be sensitive in some instances but not always specific and hence needs cautious interpretation. Tuberculosis among BCG
vaccinated children though not uncommon, needs proper documentation. Current trends in the management of tuberculosis including
CNS forms are briefly outlined. 相似文献
76.
77.
15 patients with acute myeloid leukaemia (AML) were treated with low-dose cytosine arabinoside (LD ARA-C). 2 patients had complete remissions, which lasted for 8 and 3 months, and 5 patients had a partial remission. 46% of the patients thus responded to LD ARA-C. This included 1 responding patient who had not previously responded to therapy with 6-mercaptopurine, thioguanine, or vinblastine. The 2 patients with complete remission did not show LD ARA-C-induced hypoplasia of bone marrow, although 1 had hypoplastic AML before therapy. Leukaemic cells from 1 patient showed in vivo maturation from M1 to M3 after LD ARA-C treatment. The present results, together with the published data, indicate that: a. LD ARA-C treatment, although it may have some toxic effects, is an effective treatment for some patients with AML, especially those with hypoplastic AML; b. Response to LD ARA-C can be obtained after one or several courses of treatment; c. LD ARA-C-induced remissions are sometimes obtained even in patients who fail in more conventional treatments; d. LD ARA-C-induced remissions can be achieved without bone marrow hypoplasia, and induction of hypoplasia by itself does not always result in complete remission; e. LD ARA-C can induce in vivo maturation of leukaemic cells. It is suggested that induction of remission in AML patients by LD ARA-C may result from either differentiation of leukaemic blast cells, cytotoxicity to leukaemic blasts, or both mechanisms acting together. 相似文献
78.
Karl Lehner M.D. Maximilian Reiser Ulrich Gebhardt Andreas Heuck Jürgen Schaff 《Cardiovascular and interventional radiology》1987,10(2):71-74
In contrast to conventional film angiography, the perfusion pattern of hepatic arterial chemotherapy was consistently visualized
by DSA in 40 patients with implanted Infusaid pump or Port-A devices. Incomplete perfusion of a liver region by the cytotoxic
agent was recognized by DSA as accurately as by nuclide scintigraphy. Furthermore, DSA appeared to be more sensitive in determining
aberrantly perfused extrahepatic regions; this was especially true when there was a nonligated right hepatic artery. Specific
details of vascular lesions and associated complicating events also could be satisfactorily analyzed by DSA only. 相似文献
79.
KAR NENG LAI JOSEPH W. C. LEUNG PAUL N. M. CHENG FERNAND MAC-MOUNE LAI 《Journal of gastroenterology and hepatology》1987,2(5):467-472
Dialytic ultrafiltration with haemofilter was performed in 16 patients with malignant ascites refractory to treatment with sodium restriction, diuretic and systemic chemotherapy. A continuous flow of ascitic fluid at a rate of 300–400 ml/min through a haemofilter was maintained by a blood pump. The protein-rich ascitic fluid was re-infused into the peritoneal cavity with sodium and water removed. An average of 5.2 1 of filtrate was removed over a mean interval of 3.5 h. Bleomycin (60 mg) was administered intraperitoneally following the procedure. Complete response was observed in six patients (37.25%) and partial response occurred in four (25%). The remaining patients showed no response. Complications of the dialytic ultrafiltration procedure and toxicity of intraperitoneal administration of bleomycin were minimal. The technique of dialytic ultrafiltration is simple, safe and cost-effective and could be used as an adjuvant therapy for intraperitoneal chemotherapy. 相似文献
80.
腹腔游离癌细胞测定在大肠癌治疗中的临床意义 总被引:5,自引:0,他引:5
目的:评价腹腔游离癌细胞测定的临床价值。方法:126例进展期大肠癌患者,术中探查前先用100ml生理盐水冲洗腹腔,然后从Douglas窝中取出50ml生理盐水进行细胞离心检测,共检测出癌细胞阳性72例(57.14%),将其随机分成两组,一组接受早期腹腔温热化疗及静脉化疗,另一组接受静脉化疗,结果:静脉化疗组腹腔内复发9例,肝转移4例;早期腹腔温热化疗组,腹腔内复发2例,肝转移3例,两组复发率有显著差异;两组均未见严重并发症。结论:腹腔游离癌细胞测定有助于指导大肠癌术后早期进行腹腔温热化疗并对判断大肠癌预后有一定的价值。 相似文献