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61.
目的设计合成2-(E)-(4-甲磺酰基)亚苄基环戊酮Mannich碱类化合物,并对其抗炎活性进行初步评价.方法以环戊酮、4-甲磺酰基苯甲醛及胺类化合物为原料,经多步反应合成目标化合物,并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性.结果与结论共合成10个新化合物,经1H-NMR和MS确证其结构.初步药理实验结果显示9个目标化合物均具有一定的抗炎活性. 相似文献
62.
4%与1%吲哚美辛乳膏的镇痛抗炎作用比较 总被引:1,自引:0,他引:1
目的:观察4%与1%吲哚美辛乳膏的镇痛抗炎作用.方法:以1%吲哚美辛乳膏为对比,对几种炎症、疼痛模型考察4%吲哚美辛乳膏的治疗作用.结果:4%吲哚美辛乳膏对甲醛致小鼠足部疼痛、热板法致小鼠足部疼痛、大鼠尾部压痛均有明显镇痛效果,对卡拉胶致大鼠足肿胀和二甲致小鼠耳肿胀有明显抗炎效果.结论:4%吲哚美辛乳膏具有明显的镇痛抗炎药效,优于1%吲哚美辛乳膏. 相似文献
63.
卡介菌多糖核酸的抗炎和抗过敏作用 总被引:18,自引:1,他引:18
目的 研究卡介菌多糖核酸 (BCG PSN)的抗炎、抗过敏作用。方法 观察对磷酸组胺所致豚鼠皮肤瘙痒的影响 ;采用二甲苯所致小鼠耳廓肿胀及角叉菜胶所致大鼠足跖肿胀实验观察抗炎作用 ;以 2 ,4 二硝基氟苯所致小鼠皮肤迟发型变态反应、大鼠同种被动皮肤过敏反应及小鼠异种被动皮肤过敏反应 ,探讨抗过敏作用。结果 豚鼠隔日肌内注射BCG PSN(0 1,0 2 ,0 4mg·kg-1) 3wk ,对磷酸组胺所致皮肤瘙痒无明显影响。小鼠隔日肌内注射BCG PSN(0 15 ,0 30 ,0 6 0mg·kg-1) 3wk ,可剂量依赖性地抑制二甲苯所致耳廓肿胀和耳异种被动皮肤过敏反应 ,高剂量时也可显著抑制 2 ,4 二硝基氟苯诱导的迟发型变态反应。大鼠隔日肌内注射BCG PSN(0 1,0 2 ,0 4mg·kg-1) 3wk ,可剂量依赖性地抑制角叉菜胶所致足跖肿胀和同种被动皮肤过敏反应。收稿日期 :2 0 0 3 -12 -2 4,修回日期 :2 0 0 4-0 2 -12作者简介 :刘桂珍 ( 1965 -) ,女 ,主管实验师 ,研究方向 :心血管药理学。Tel:0 73 1 2 3 5 5 0 77;胡长平 ( 1969-) ,男 ,博士 ,副教授 ,通迅作者 ,研究方向 :心血管药理学 ,Tel:0 73 1 2 3 5 5 0 77,E mail:huchangping2 0 0 1@yahoo .com .cn结论 BCG PSN对急性炎症、速发型变态反应和迟发型变态反应具有抑制作用。 相似文献
64.
65.
《Expert opinion on investigational drugs》2013,22(8):1147-1168
Several epidemiological studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer's disease (AD), especially for patients carrying one or more ?4 allele of the apolipoprotein E. The biological mechanism of this protection is not completely understood and may involve inhibition of COX activity, inhibition of β-amyloid1-42 (Aβ42) production and aggregation, inhibition of β-secretase activity, activation of PPAR-γ or stimulation of neurotrophin synthesis. Unfortunately, long-term, placebo-controlled clinical trials with both non-selective and COX-2 selective NSAIDs in AD patients produced negative results. A secondary prevention study with rofecoxib in patients with mild cognitive impairment and a primary prevention study with naproxen and celecoxib in elderly subjects with a family history of AD were also negative. All these failures have diminished the hope that NSAIDs could be beneficial in the treatment of AD. It is hypothesized that the chronic use of NSAIDs may be beneficial only in the normal brain by inhibiting the production of Aβ42. Once the Aβ deposition process has started, NSAIDs are no longer effective and may even be detrimental because of their inhibiting activity on activated microglia of the AD brain, which mediates Aβ clearance and activates compensatory hippocampal neurogenesis. 相似文献
66.
《Current medical research and opinion》2013,29(8):542-546
SummaryA trial was carried out to assess the value of ibuprofen in relieving the symptoms and signs in 40 patients suffering from inflammatory phlebopathies of the lower limbs. Ibuprofen was given in a dosage of 900?mg. daily for periods ranging from 7 to 28 days. Spontaneous pain, redness and oedema showed a marked reduction, on average by the third day, although pain on pressure persisted for about 10 days. Body temperature returned to normal within a few hours. The results were assessed as excellent in 10, good in 19,fair in 8, and poor in 3 patients. Side-effects were reported inonly 3 patients and were mild. 相似文献
67.
《Current medical research and opinion》2013,29(8):513-515
SummaryA study was carried out to determine the effects of ibuprofen, phenylbutazone and indomethacin at different concentrations on phytohaemagglutinin-induced stimulation of lymphocytes in vitro. The results indicate that all three drugs inhibit lymphocyte stimulation, and at concentrations achieved by ibuprofen and phenylbutazone in vivo. It may be, therefore, that part of the effect of ibuprofen in rheumatoid arthritis is due to inhibition of lymphocyte function. 相似文献
68.
《Expert opinion on pharmacotherapy》2013,14(2):211-219
Background: Colorectal cancer (CRC) is one of the most common cancers worldwide and a prevalent cause of morbidity and mortality. CRC has a natural history of transition from a precursor lesion, ie adenomatous polyp to cancer, that spans over 10 to 15 years providing an extended opportunity for intervention and cancer prevention. Suppression of the carcinogenic process by use of pharmacological or natural agents is the cornerstone of chemoprevention. Objectives: The aim of this review was to give an up-to-date overview on the different agents that had been studied, over the last decade, as chemopreventive agents and the current status of chemoprevention. Methods: Articles were identified by searches of PubMed and the Internet and reviewed. All articles and other referenced materials were retrieved using the keywords “colon cancer”, “adenoma”, “chemoprevention”, “non steroidal anti-inflamatory drugs”, “aspirin”, “HMG-CoA reductase inhibitors”, “bile acids”, “Difluoromethylornithine”, “hormone replacement therapy”, “mesalamine”, “curcumin”, and “calcium”. Papers were published between 1960 and 2008, with older references selected for historical significance. Only papers published in English were reviewed. Results: Recent preclinical as well as clinical trials have provided data on the potential benefit of a number of drugs and nutritional elements in the field of CRC prevention. Currently, only celecoxib is FDA approved for chemoprevention of CRC and only for high-risk patients with Familial Adenomatous Polyposis (FAP). This is mainly due to cardiovascular toxicity reported in individuals with a personal history of sporadic adenomas. Aspirin and sulindac have also repeatedly demonstrated efficacy in this setting. However, due to increased risk of associated GI toxicity their benefit will have to be weighed against their risk. Combination therapy, using lower doses of each medication, is drawing a great deal of attention and many studies utilizing a variety of chemopreventive agents are presently under study. Promising results have recently been published using sulindac and DFMO. Conclusion: Many agents have shown positive results in the field of chemoprevention however, the ideal chemopreventive agent remains to be discovered with great emphasis on need not to harm. Combining different agents may maximize effectiveness while limiting drug toxicity. 相似文献
69.
Context: Pterocephalus hookeri (C. B. Clarke) Hock., a traditional Tibetan herbal medicine rich in glycosides, has been used to treat several diseases including rheumatoid arthritis.Objective: To evaluate the anti-arthritic activity of total glycosides from P. hookeri, and its possible mechanisms of action.Materials and methods: Anti-arthritic activity of total glycosides from P. hookeri (oral administration for 30 days at 14–56?mg/kg) was evaluated using paw swelling, arthritis scores and histopathological measurement in adjuvant-induced arthritis (AA) Sprague-Dawley rats. The NF-κB p65 expression in synovial tissues, and serum superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) levels was measured in AA rats, respectively. Further assessment of anti-inflammatory and analgesic activities of these glycosides were carried out using inflammation and hyperalgesia models induced by xylene, carrageenan, agar and acetic acid, respectively.Results: Total glycosides (56?mg/kg) decreased the paw swelling (38.0%, p?0.01), arthritis scores (25.3%, p?0.01) and synovial inflammation in AA rats. The glycosides significantly (p?0.05–0.01) attenuated the inflammation induced by xylene, carrageenan, acetic acid and agar, increased the pain threshold in acetic acid-induced writhing in mice and mechanical stimuli-induced hyperalgia in AA rats. The glycosides (14, 28, 56?mg/kg) also suppressed the NF-κB p65 expression (33.1–78.2%, p?0.05–0.01), reduced MDA (21.3–35.9%, p?0.01) and NO (20.3–32.4%, p?0.05–0.01) levels, respectively, enhanced the SOD activity (7.8%, p?0.05) at 56?mg/kg in AA rats.Discussion and conclusion: Our findings confirmed the anti-arthritic property of the total glycosides from P. hookeri, which may be attributed to its inhibition on NF-κB signalling and oxidative stress. 相似文献
70.
Autoimmune sensorineural hearing loss (ASNHL) is a clinical syndrome that typically produces a bilateral rapidly progressive hearing loss. Autoantibodies and autoreactive T cells have been implicated in the etiopathogenesis of ASNHL. However, the identity of a specific or highly relevant inner-ear self-antigen is still required. In recent years, a role for antiphospholipid antibodies has been also suggested, assuming sudden/progressive hearing loss to be part of the primary antiphospholipid syndrome (APS).In this review, we address the need for specific diagnostic tools in order to establish an autoimmune origin for hearing loss. Moreover, the decision of whether anti-inflammatory drugs or anti-coagulation should be given is also discussed. 相似文献