腹腔注射细菌脂多糖加重大鼠的应激性抑郁症

目的 观察腹腔注射细菌脂多糖对大鼠应激性抑郁症的影响。方法 制备大鼠应激性抑郁症模型，采用开场实验检测大鼠的行为性抑郁，用MTT法测定淋巴细胞转化。结果 慢性应激16d，大鼠出现自主活动时间和中区逗留时间缩短、活动路程减少等抑郁性行为。腹腔注射细菌脂多糖加重大鼠的行为性抑郁，并加强应激大鼠血清对正常淋巴细胞转化的抑制作用。结论 腹腔注射细菌脂多糖加重大鼠的行为性抑郁，其原因可能与脂多糖引起的脑内炎性细胞因子的释放有关。     

下颌骨骨折坚固内固定应力遮挡的三维有限元分析

目的 :运用有限元法分析下颌骨功能状态下及坚固内固定时的应力分布 ,探讨可能发生的应力遮挡作用 ,为下颌骨骨折的治疗提供参考。方法 :对下颌骨体部骨折在骨愈合的不同时期及采用不同的内固定方法固定时的应力分布进行有限元法分析 ,计算各种工况下的应力遮挡率。结果 :骨折愈合的早期 ,单、双钢板固定时的应力遮挡率分别为98.90 %、99.63 % ,钛板为98.65%、99.58 % ;骨折愈合的中期 ,单、双钢板固定时的应力遮挡率分别为6.8%、22.96 % ,钛板为5.12 %、20.99 % ;骨折愈合的后期 ,单、双钢板固定时的应力遮挡率分别为5.73 %、14.14 % ,钛板为4.47 %、13.71 %。结论 :小型接骨板用于下颌骨体部骨折坚固内固定时 ,在骨折愈合的各个时期均存在明显的应力遮挡作用 ;钢板的应力遮挡作用大于钛板 ;接骨板固定位置的选择对骨断层的应力分布有重要的影响。     

全麻手术对肥胖患者血浆抵抗素和肾素血管紧张素及血糖的影响

目的　研究全麻诱导以及手术对肥胖患者血浆抵抗素 (resistin)和肾素、血管紧张素Ⅱ及血糖的影响。方法　选择 4 0例全麻手术患者 ,根据BMI指数分为两组 :A组 (BMI>2 5 ) 2 0例为肥胖者 ;B组 (2 1 相似文献   

Pelvic pain and recurrent urinary incontinence after laparoscopic colposuspension with the endo-stapler

Laparoscopic colposuspension is one of many new operations for treating female urinary stress incontinence. With initially reported success rates similar to those of the traditional open procedure, it appears to combine the advantages of laparoscopy (such as minimal invasiveness and quicker return to normal activities) with the effectiveness of the standard procedure. Different methods and approaches are used, but endoscopic suture techniques remain difficult and time-consuming. The use of endostapling devices for fixation of alloplastic material has been a tempting alternative. We present a case during which laparoscopic colposuspension was performed using staples and mesh. Incontinence did not improve, and the patient suffered severe chronic pain for 18 months postoperatively. Removal of the alloplastic material and traditional abdominal resuspension led to complete cure.     

Temporal stability of lipid responses to acute psychological stress in middle-aged men

The purpose of this study was to establish the temporal stability of lipid responses to acute psychological stress. Eighteen men were tested twice an average of 16.2 months apart in identical laboratory reactivity protocols. Total cholesterol, triglycerides, high- and low-density lipoprotein-cholesterol, plasma volume, heart rate, and blood pressure were assessed during rest, serial subtraction, and speech. After correction for changes in plasma volume, significant elevations were recorded for all variables during the speech task, but fewer variables showed changes during the serial subtraction task. Strong intersession associations were found when considering levels of the variables during baseline and stress (rs≥58). Correlations for the change scores ranged from .36 to .52 for the atherogenic lipids and from .39 to .87 for the cardiovascular variables. Little evidence was found for stability of plasma volume changes. There is moderate to high temporal stability of the atherogenic lipids when considering rest and stress levels and small to moderate temporal stability when considering change scores.     

Urethral closure function in women with prolapse

In 19 patients with different types of severe descensus, all without clinical evidence of stress incontinence, urethral stress pressure profiles and stress tests were done before and after repositioning of the prolapse. In 13 of the 19 patients, continence was artificial, because during repositioning they showed leakage of urine; however, 6 of the patients remained continent. The pressure transmission ratios decreased in different parts of the urethra in all the patients when repositioning with a gynecological speculum was done. The drop was most significant in those patients who lost urine after repositioning, showing poor urethral function. In women with genito-urinary prolapse, a test of urethral function is essential, even if there is no clinical evidence of incontinence after removal of the descensus. In cases of severe stress incontinence under this condition, a procedure for bladder neck stabilization should be added to routine prolapse surgery.     

重度失水所致应激性高血糖症

本文报道2例肠梗阻和1例有机磷农药中毒患者出现暂时性高血糖症。该3例患者均无糖尿病史,因有重度失水,经大量补液纠正失水后血糖迅速恢复正常。口服葡萄糖耐量试验正常。作者认为非糖尿病患者可因重度失水而致应激性高血糖症。     

环烃的张力与几何结构参数的定量关系

本文探讨了环烷烃、环烯烃、双环[n.1.0]烷烃和双环[n.m.1]烷烃的张力与几何参数间的定量关系,得到十个满意的线性相关方程。     

Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma

Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants. However, other factors or drugs (e.g. cresol) are thought to induce MH. We report a case of fulminant MH associated with a ketoacidotic diabetic coma. After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness. MH was treated immediately with dantrolene; the patient recovered within 14 days. Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test. This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. Furthermore, therapy with dantrolene has been demonstrated to the beneficial in the treatment of MH associated with diabetic coma.     

Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats

 Previous studies using a reinstatement procedure have found that acute reexposure to the self-administered drug and exposure to footshock stress reinstate heroin and cocaine seeking after prolonged drug-free periods. Here we tested whether these findings generalize to alcohol-taking behavior. Male rats were initially allowed to consume alcohol in a two-bottle choice procedure (water versus alcohol) for 30 min/day for 36 days. Rats were then trained for 60 min/day in operant chambers to press a lever for the drug (0.13 ml of 12% w/v of an alcohol solution) for up to 55 days. After stable drug-taking on a fixed-ratio-3 schedule of reinforcement was obtained, lever pressing for alcohol was extinguished by terminating drug delivery for 4–9 days. Reinstatement of drug seeking was then determined after non-contingent priming injections of alcohol (0.24 and 0.48 g/kg; given IP and orally) or exposure to intermittent footshock stress (5 and 15 min; 0.8 mA). Priming injections of alcohol produced a modest dose-dependent reinstatement of drug seeking, whereas footshock stress potently reinstated extinguished alcohol seeking. In contrast, similar parameters of footshock failed to reinstate extinguished sucrose-taking behavior in rats previously trained to lever press for sucrose pellets. These findings extend previous reports on reinstatement of cocaine and heroin seeking by a footshock stressor and by priming drug injections. It also appears that the reinstatement procedure provides an appropriate methodology to study relapse to alcohol-taking behavior in the drug-free state. Received: 9 April 1997 / Final version: 1 August 1997