运脾法的理论与实践

根据文献资料和临床实践体会，介绍运脾法的理论意义及其在临床上的应用，分述为运脾化湿法、运脾和胃法、温运脾阳法、养胃助运法、理气助运法、益气助运法，以期探讨运脾法的实质。     

吴茱萸汤方证学研究

采用病案调查的方法，从方证学角度对吴茱萸汤进行研究探讨，通过150例病案分析，探寻吴茱萸汤证的一般发病规律，主症、副症、舌脉分布规律，以及临证药物配伍、用法用量等规律，通过这些规律的探索，为临床正确使用该方提供参考依据。     

经方研究的切入点

经方因有经典著作和具体条文作背景,比其他方剂拥有更多的精华内涵,对其研究不应局限在方中的几位药上,而应有更多的切入点.其中包括特征性的辨证要点,体质与疾病,经方内部药量比例,剂型的内涵,煎服中的文章和药后反应中的玄机.     

《金匮》肾气丸义理及衍变

《金匮》肾气丸为温补肾阳之剂，乃阴阳兼顾，阴中求阳，益肾生气，温补肾阳之总方。其在《金匮要略》中治寒湿脚气、虚劳腰痛、痰饮、消渴、转胞凡五病。后世师其法而立新方者甚多，诸如济生肾气丸、十补丸、右归丸、右归饮、六味地黄丸、知柏地黄丸、杞菊地黄丸、麦味地黄丸、左归丸、左归饮等。     

关于大方治疗疑难病的思考

本文就应用大方治疗疑难病的必要性作初步探讨。认为疑难病的病因、病机、病情复杂，主要矛盾和次要矛盾处于不断的变化中，当次要矛盾的地位上升到一定程度时，应用小方难以达到最佳疗效，而应用大方却能取得理想的疗效。这是因为大方可以从不同的点面发挥作用，在抓主要矛盾的同时，更重视兼顾次要矛盾，最终使疾病得以缓解。     

肝癌患者脾脏免疫状态的研究

对16例肝癌病人外周血及脾静脉血T淋巴细胞亚群检测结果：1）肝癌患者较对照组外周血CD 3、CD 4细胞及CD4／CD8比值降低，CD 8细胞升高。2）肝癌患者脾静脉血较外周血CD 3、CD 4阳性细胞、CD4／CD8比例明显降低，CD 8显著升高。认为随着病程进展，脾脏不但不起正性免疫作用，反而转向负性免疫状态。同时，还对肝癌患者的脾脏手术问题进行了讨论。     

脾胃康口服液健脾止泻作用的药理研究

脾胃康口服液对生大黄冷浸液灌胃引起的小鼠腹泻有较好止泻作用，并能对抗甲基新斯的明引起的小肠推进机能亢进，改善小鼠脾虚体征，促进血清溶血素形成，对于ＤＮＣＢ诱导小鼠ＤＴＨ反应具有增强作用。     

壮医药线点灸三种手法对脾虚证治疗作用的研究

目的：观察比较壮医药线点灸轻、中、重３种手法对脾虚证患者的临床疗效。方法：６０例脾虚证患者随机分为轻、中、重３组，每组２０例。其中轻法组采用壮医药线点灸轻手法治疗，中法组采用壮医药线点灸中手法治疗，重法组采用壮医药线点灸重手法治疗。结果：３种手法对脾虚证的主要临床症状及唾液负荷分泌水平均有改善作用（Ｐ＜００５），其中中、重法效果较轻法优（Ｐ＜００５）。３种手法治疗总有效率分别为８０％，９５％，９０％结论：壮医药线点灸轻、中、重３种手法对脾虚证确有疗效，且疗效与施术手法有关。     

Septic complications after splenectomy for sickle cell sequestration crisis

Patients with sickle cell disease (SCD) are predisposed to infections. There is a paucity of recent information on the incidence of post-splenectomy infectious complications in these patients. The purpose of this study was to determine whether splenectomy increases infectious complications in SCD. Twenty-nine patients with SCD had splenectomy for sequestration crises at our hospital between 1988 and 1992; 16 of them received all of their follow-up care at our institution. These 16 charts were reviewed for infectious-related admissions, hospital days, days of IV antibiotics, positive cultures, and episodes of sepsis. For each patient, these parameters in the pre- and postoperative period were compared and expressed as number per year. The mean age at time of splenectomy was 2.5 ± 0.4 years and the mean follow-up was 4.5 ± 0.4 years. There was no significant difference in the pre- and postoperative periods for admissions, hospital days, days of IV antibiotics, positive cultures, or episodes of sepsis per year. There were also no operative deaths. The incidence of pre-splenectomy sepsis was 0.04 ± 0.03 episodes per year compared to 0.09 ± 0.04 (P = ns) episodes/year after splenectomy. Sepsis occurred at an average of 20.8 (range 2–30) months postoperatively; Streptococcus pneumoniae was the most common causative organism. The total mortality after splenectomy in SCD patients was 3.4% (1/29) over a nearly 5-year period. Although infections are common in children with SCD, there was no increase in infections or episodes of sepsis in SCD patients who underwent splenectomy. Accepted: 6 March 1997     

门静脉高压症患者脾内血管病变及其发病机制的研究

探讨门静脉高压症患者脾内血管病变及其机理。方法对２８例门静脉高压脾脏和１０例正常脾破裂脾脏切除标本,行ＨＥ染色和ＭＡＳＳＯＮ染色,观察血管形态学改变;免疫组织化学法检测增殖细胞核抗原（ＰＣＮＡ）、血管内皮生长因子受体１（Ｆｌｔ－１）的蛋白质表达;原位杂交法检测血管内皮生长因子、碱性成纤维细胞生长因子的ｍＲＮＡ表达。