全文获取类型
收费全文 | 1836篇 |
免费 | 54篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 382篇 |
儿科学 | 43篇 |
妇产科学 | 2篇 |
基础医学 | 115篇 |
口腔科学 | 59篇 |
临床医学 | 106篇 |
内科学 | 15篇 |
皮肤病学 | 1篇 |
神经病学 | 371篇 |
特种医学 | 188篇 |
外科学 | 273篇 |
综合类 | 201篇 |
预防医学 | 24篇 |
眼科学 | 4篇 |
药学 | 47篇 |
中国医学 | 16篇 |
肿瘤学 | 76篇 |
出版年
2023年 | 16篇 |
2022年 | 50篇 |
2021年 | 58篇 |
2020年 | 37篇 |
2019年 | 40篇 |
2018年 | 31篇 |
2017年 | 64篇 |
2016年 | 63篇 |
2015年 | 63篇 |
2014年 | 117篇 |
2013年 | 111篇 |
2012年 | 83篇 |
2011年 | 116篇 |
2010年 | 102篇 |
2009年 | 112篇 |
2008年 | 100篇 |
2007年 | 103篇 |
2006年 | 84篇 |
2005年 | 76篇 |
2004年 | 71篇 |
2003年 | 48篇 |
2002年 | 42篇 |
2001年 | 33篇 |
2000年 | 38篇 |
1999年 | 32篇 |
1998年 | 32篇 |
1997年 | 31篇 |
1996年 | 17篇 |
1995年 | 30篇 |
1994年 | 21篇 |
1993年 | 10篇 |
1992年 | 12篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 5篇 |
1982年 | 6篇 |
1981年 | 2篇 |
1980年 | 5篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1976年 | 3篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1968年 | 2篇 |
排序方式: 共有1923条查询结果,搜索用时 625 毫秒
11.
Aims and Objectives The significance of beaten copper appearance (BCA) on skull radiographs in children following surgery for isolated sagittal
craniosynostosis has not been studied. This study was designed to look for any correlation between BCA and symptoms suggestive
of intracranial hypertension in this group of patients.
Materials and Methods Forty-eight consecutive children, who were operated for isolated sagittal synostosis from1987 to 2000 and had postoperative
skull radiographs, were included. Patients were divided into: (a) BCA group (n = 20), consisting of children who had beaten copper appearance on skull radiographs at last follow up, and (b) Non-BCA group
(n = 28), consisting of children who did not have this finding. Records were reviewed to look for symptoms suggestive of intracranial
hypertension, such as headache, head banging, and irritability.
Results Median age at surgery was 4.8 months for BCA group and 4 months for the non-BCA group. Follow up ranged from 4 to 156 months
with a mean of 36.2 months. Total of 28.6% (n = 6) of the children with follow up radiographs done at ≤18 months of age had BCA. The incidence of BCA increased to 83.3%
in children with skull radiographs performed after 48 months of age. In 18 (90%) children, the BCA was ‘diffuse’ with 5 (25%)
children having the maximum possible score of 8. In the BCA group, 45% (n = 9) had symptoms compared to 10.7% (n = 3) in the control group (p = 0.0068).
Conclusions This study suggests a significant number of children with BCA on radiographs develop symptoms suggestive of raised ICP following
surgical treatment in infancy and prolonged follow up may be warranted in this group of patients. 相似文献
12.
脑膜瘤骨侵袭行为中血管内皮生长因子表达研究 总被引:7,自引:1,他引:6
目的研究脑膜瘤不同的骨侵袭行为中血管内皮生长因子(VEGF)表达的差异性,探讨VEGF在骨侵袭中的生物学意义。方法应用HE染色和免疫组化方法检测36例脑膜瘤标本及受累骨质的病理类型及VEGF蛋白表达水平,进行病理学对比观察。结果36例标本中有骨侵袭的23例,VEGF表达为强阳性者5例,阳性者17例,阴性者1例;13例无肿瘤骨侵袭标本中,VEGF表达为强阳性者1例,阳性者6例,阴性者6例。脑膜瘤骨侵袭与VEGF表达程度显著相关(P<0.05)。VEGF主要表达于脑膜瘤细胞的胞浆,在肿瘤向骨组织浸润最明显处表达最强。结论VEGF表达水平反映脑膜瘤对相邻骨质的侵袭能力;VEGF参与脑膜瘤骨病理改变的形成机制。 相似文献
13.
14.
P. J. Donald 《European archives of oto-rhino-laryngology》2007,264(7):713-717
The purpose of this paper is to detail the contraindications for surgery, with curative intent for those patients who suffer
from a head and neck malignancy that invades the intracranial space. This is based on a 30-year experience of over 250 patients.
The most important contraindications are anatomical. Surgery is not done if the following structures are invaded: brain stem,
eloquent portions of the cerebrum, superior sagittal sinus, both internal carotid arteries, both cavernous sinuses and certain
vital bridging veins. Certain tumor factors are absolute but are occasionally relative contraindications: such as distant
metastatic disease especially if multiple and at multiple anatomic sites. Some tumors that behave in a particularly virulent
fashion that defy complete resection but are often difficult to predict preoperatively. Lack of patient medical fitness or
absence of patient commitment to the operative procedure is make-up two serious contraindications to surgery.
Presented at the 77th Annual Meeting of the German Society for Oto-Rhino-Laryngology, Head and Neck Surgery, 24–28 May 2006,
Mannheim, Germany. 相似文献
15.
应用细孔钻颅穿刺术诊断和治疗颅内肿瘤9例,7例有颅内压增高症状和神经功能缺失。9例中囊性肿瘤6例,囊液最少者15ml,最多者115ml,平均50ml,穿刺放液后症状均改善,为手术赢得了时间;3例实质性肿瘤,穿刺活检有助于星形细胞瘤的确诊。 相似文献
16.
M.R.C. Naidu D.R. Reddy K.V.R. Sastry P.K. Reddy 《Clinical neurology and neurosurgery》1987,89(4):265-267
Osteomyelitis of the skull is an uncommon disease in the present days, mainly due to the advent of modern and more effective antibiotics. Hematogenous osteomyelitis is very rare. Osteomyelitis of the skull is usually not associated with sclerosis which is commonly seen in the rest of the skeleton. There are only few occasional case reports of condensing osteomyelitis wherein there was sclerosis of the bone associated with osteomyelitis of the skull and epidural abscess. An unusual case of diffuse condensing osteomyelitis of the skull producing unilateral proptosis is reported. The clinical, radiological features and microbiological aspects are presented. The proptosis was treated by excision of the bone behind the eyeball and thus relieving the proptosis and the impaired vision. The patient was given broad spectrum antibiotics for a period of two months. Further management problems are discussed. 相似文献
17.
Basilar skull fractures involving the temporal bone extend through the tympanic part of the temporal bone in two-thirds of cases. The anatomical relationship of this part of the temporal bone and the temporomandibular joint enables air to pass from the auditory canal into the joint. Air in the temporomandibular joint is demonstrated on CT scans as an indirect sign of temporal bone fracture. 相似文献
18.
颅底胆脂瘤的MRI特征 总被引:8,自引:0,他引:8
目的探讨颅底胆脂瘤MRI分型的意义及其MRI诊断特征。方法观察15例颅底胆脂瘤的CT、MRI与病理学资料,根据肿瘤T1WI信号的不同,将颅底胆脂瘤分为Ⅰ型和Ⅱ型,分析两型胆脂瘤在CT、MRI征象和颅底骨质侵犯等方面的差异。结果15例颅底胆脂瘤T2WI显著高信号,肿瘤实质无强化。15例中,Ⅰ型,6例,肿瘤位于桥前池和桥小脑角区,CT均匀低密度,T1WI均匀低信号,包膜不强化,颅底骨质改变轻微,肿瘤实质为胆固醇结晶;Ⅱ型,9例,肿瘤位于一侧中、后颅窝底,CT呈混杂密度,T1WI呈混杂信号,其中4例为低信号中夹杂少量高信号,另5例以高信号为主,包膜强化,颅底骨质呈显著外压性改变,肿瘤实质为角化上皮和蛋白。结论颅底胆脂瘤分为Ⅰ型和Ⅱ型是合理的,体现了两型颅底胆脂瘤组织病理和生物学行为的差异,对指导MRI诊断有积极意义。T1WI信号多样性、T1WI显著高信号、肿瘤实质不强化以及与MRI分型相关的颅底骨质侵犯是颅底胆脂瘤的MRI诊断特征。 相似文献
19.
Dr. Bektaş Açikgöz Mehmet Turgut Osman Ekin Özcan Tunçalp Özgen Beyhan Demirhan Şevket Ruacan 《Lasers in medical science》1992,7(1-4):49-53
In this study we have investigated the negative influence of CO2 and Nd-YAG laser irradiation on rapid cranial regeneration and whether it has any use in certain types of craniosynostosis.
Twenty-two newborn rats were used in the study. Both CO2 and Nd-YAG laser irradiation, which was applied to free bony edges after, suturectomies, resulted in a significant decrease
in skull regeneration. Histopathological examinations revealed severe degeneration caused by both types of laser energies. 相似文献
20.
应用自体颅骨碎片及骨屑对60例在造成颅骨缺损术同时行颅骨缺损修补术。缺损面积直径最小者2cm,最大者10cm。术后随访1个月至5年,病人颅骨缺损修补处外观正常,无凹陷,触之硬,与正常颅骨处类似。6个月拍X线片示颅骨修补处类似正常颅骨形态。 相似文献