Sexual Intercourse for Induction of Spontaneous Onset of Labor: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

IntroductionSexual intercourse during pregnancy is commonly believed to trigger the onset of contractions and, therefore, labor. However, in low-risk pregnancies, there is neither association with preterm birth, premature rupture of membranes, or low birth weight, nor with spontaneous onset of labor at term.AimTo evaluate the effectiveness of sexual intercourse for spontaneous onset of labor at term in singleton pregnancies.MethodsThe systematic search was conducted using electronic databases from inception of each database to June 2019. Review of articles also included the abstracts of all references retrieved from the search. Inclusion criteria were randomized controlled trials comparing sexual intercourse in singleton low-risk pregnancies at term with controls (either reduced number of coitus or no coitus) for spontaneous onset of labor. Estimates were pooled using random-effects meta-analysis.Main Outcome MeasuresThe primary outcome was the incidence of spontaneous onset of labor. The summary measures were reported as summary relative risk with 95% CI using the random-effects model of DerSimonian and Laird.ResultsData extracted from 3 trials, including 1,483 women with singleton pregnancy at term and cephalic presentation, were analyzed. Women who were randomized in the sexual intercourse group had similar incidence of spontaneous onset of labor compared with control subjects (0.82% vs 0.80%; relative risk 1.02, 95% CI 0.98–1.07).Clinical ImplicationSexual intercourse should not be restricted in low-risk term pregnancies. Further studies are needed to properly evaluate the impact of orgasm, penetration, condom use, frequency of intercourse and other factors on induction of labor at term.Strength & limitationsOur study has several strengths. The three included trials had low risk of allocation bias; intention-to-treat analysis was used; this is the first meta-analysis on this issue so far. Limitations mainly depend on the design of the included studies. Firstly, compliance to the protocol relied on self-reporting by patients; in addition, not all the features of sexual intercourse could be adequately assessed (orgasm, nipple stimulation, sexual positions, etc.).ConclusionIn women with singleton, cephalic, low-risk pregnancies, sexual intercourse at term does not significantly increase the incidence of spontaneous onset of labor.Carbone L, De Vivo V, Saccone G, et al. Sexual Intercourse for Induction of Spontaneous Onset of Labor: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Sex Med 2019;16:1787–1795.     

腰椎间盘突出症针灸治疗的相关进展

腰椎间盘突出症(LIDP)是临床上最为常见的一类脊柱退行性变基本,由于年龄或外力等因素导致腰椎间盘髓核、纤维环及软骨板有不同程度的退行性改变后突出于后方或椎管内,导致相邻脊神经根遭受刺激或压迫,从而产生腰部疼痛下肢麻木等临床症状。该病症临床上主要以物理康复、对症止痛或手术治疗等方法。祖国传统中医针灸对腰椎间盘突出症临床疗效亦较为确切,因此本文对腰椎间盘突出症针灸治疗的相关进展做一简要综述,以期为临床腰椎间盘治疗针灸治疗提供一定的参考。     

CircRNA在妇科肿瘤中的研究进展

CircRNA是非编码RNA中最为稳定的RNA分子,其稳定存在于各种生物体中并参与生物体的代谢功能调节。近年来,大量研究从基因组学及信号通路方向深入研究,发现CircRNA可与miRNA通过复杂调控参与机体各种疾病的发生及发展,其中CircRNA在肿瘤细胞的增殖、凋亡及转移中的作用备受瞩目。妇科肿瘤是妇科疾病中危害最大的疾病。本文主要从CircRNA的特征功能认知、在肿瘤发生及发展中途径、以及其在妇科肿瘤中的致病机理和未来诊断方向上,综合国内外相关研究进展进行整理,总结CircRNA在妇科肿瘤中的临床应用。     

川陈皮素抗肿瘤机制研究进展

作为我国传统中药之一的陈皮，在许多的肿瘤治疗中具有重要的辅助作用。桔皮多甲氧基黄酮类化合物的一种成分川陈皮素，具有抗癌、抗血栓、抗癫痫、抗血凝、抗真菌、抗过敏、抗炎、抗胆碱酯酶等作用。川陈皮素抗肿瘤研究的人越来越多，但其机制仍在研究中，据报道，川陈皮素抗肿瘤机制可能是：首先，抑制肿瘤细胞的生长和增殖；第二，诱导肿瘤细胞凋亡；第三，抑制肿瘤细胞的迁移和侵袭；四是调节癌细胞周期和蛋白表达以及与化疗药物的联合增强抗肿瘤作用有关。本文通过对国内外近10几年来发表的川陈皮素文献进行分析，发现其对多种肿瘤细胞都有抑制作用，将来可能发展为全能型抗肿瘤药物，为川陈皮素在临床抗肿瘤应用中提供参考依据，现就川陈皮素抗肿瘤的相关研究进展进行以下综述。     

Progress in clinical trial of histone deacetylase （HDAC） inhibitors for non-small cell lung cancers

Histone deacetylase （HDAC） inhibitors, which represent a structurally diverse group of molecules, have emerged as a novel therapeutic class of molecules with significant anticancer potential. Vorinostat and romidepsin, known as the first generation of HDAC inhibitors, were approved in the United States for the treatment of T-cell lymphomas. Preliminary activity of HDAC inhibitors has also been observed in non-small cell lung cancer （NSCLC） in combination with the existing treatment regimens, of which is the focus of the current review.     

宫颈癌IMRT与BT联合应用研究进展

BT是宫颈癌根治性放疗的重要组成部分。随着放疗技术不断发展,对于盆腔体外IMRT后残存肿瘤体积大、伴有宫旁浸润的宫颈癌患者,有学者提出了BT同步IMRT的治疗技术。本文回顾近年来IMRT与BT综合应用在宫颈癌治疗中的研究进展。     

Retirement and health: Evidence from England

This paper utilizes census records, inpatient records, comprehensive surveys, and mortality records from England to trace out the effect of reaching retirement age on retirement status and health outcomes. Applying a regression discontinuity design leveraging the pension age, I find that retirement substantially improves well-being and reported health. I find no immediate effect of retirement on behavioral outcomes and no evidence of changes to cognitive ability, utilization, or mortality. While prior literature has considered the effects of retirement on specific outcomes, this paper systematically examines the full range of health-related outcomes with administrative and survey data in a unified context.     

中医药治疗颈性眩晕的研究进展

颈性眩晕是常见的骨科疾病,主要以老年人为主,已严重影响了人们的生活与工作。近年来中医通过多种特色疗法取得了很好疗效。但目前没有统一的辨证分型和理法方药,还需进一步研究。     

产前认知辅导对初产妇分娩方式及产程时间的影响

目的探讨产前认知辅导对初产妇分娩方式及产程时间的影响。方法选取2016年1~12月间我院妇产科收治的初产妇80例,依据随机数字表法分为产前常规检查组(n=40)和产前认知辅导组(n=40)。对两组初产妇的分娩方式、配合分娩情况及自然分娩初产妇的各阶段产程时间进行统计分析。结果产前认知辅导组初产妇的自然分娩率为75.0%(30/40)显著高于产前常规检查组52.5%(21/40)(P0.05),剖宫产率、社会因素剖宫产率、难产率分别为22.5%(9/40)、5.0%(2/40)、22.5%(9/40)均显著低于产前常规检查组42.5%(17/40)、25.0%(10/40)、45.0%(18/40)(P0.05),配合好比例[72.5%(29/40)]显著高于产前常规检查组[35.0%(14/40)](P0.05),配合一般、配合差比例[22.5%(9/40)、5.0%(2/40)]均显著低于产前常规检查组[42.5%(17/40)、22.5%(9/40)](P0.05),自然分娩初产妇的第二产程、总产程时间均显著短于产前常规检查组(P0.05)。结论产前认知辅导能够有效提升初产妇的自然分娩率,降低初产妇的剖宫产率,并缩短自然分娩初产妇的产程时间。     

精密注塑机的最新技术进展及发展趋势

本文通过分析注塑机锁模结构、驱动方式的变化,从精密、高效、节能、环保等方面,阐述了精密注塑机的最新技术进展及发展趋势.