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71.
Linkage studies and mutation analysis of the PDEB gene in 23 families with Leber congenital amaurosis. 总被引:1,自引:0,他引:1
The phenotype in the rd mouse is similar to the clinical presentation of Leber congenital amaurosis (LCA) in humans. Recently a nonsense mutation in the beta subunit of the cGMP phosphodiesterase (Pdeb) gene has been defined as the cause for the rd phenotype in the mouse and has raised the question as to whether mutations in the human PDEB gene might cause LCA. We have previously cloned and characterized the human homologue of the mouse Pdeb gene and have mapped it to chromosome 4p16.3. In this study, a total of 23 LCA families of various ethnic backgrounds have been investigated. Linkage analysis using highly polymorphic (CA)n microsatellites has excluded the PDEB gene as a cause for LCA in 6 families. In the remaining 17 families, we have searched for mutations in the 22 exons of the PDEB gene using single-strand gel electrophoresis (SSGE). Multiple exonic polymorphisms have been determined. However, no DNA changes in the PDEB gene have been identified in our study population which could be causative for the LCA phenotype. 相似文献
72.
Jeffrey V. Rosenfeld MS FRACS FRCS 《Journal of clinical neuroscience》1994,1(4):231-242
Great advances in neurobiology have resulted from 100 years of neural transplantation research. In the last 20 years, there has been a focus on using neural transplantation to repair the damaged central nervous system (CNS) utilising experimental animal models of various human neurodegenerative disease and CNS injury. Since 1985, there has been a rapid proliferation of adrenal medullary autograft transplantation to the caudate nucleus of humans with Parkinson's disease. However, this operation proved to be unsuccessful and was associated with unacceptable morbidity. Implantation of human fetal mesencephalon into patients with severe parkinsonism has supplanted the adrenal operation and has produced promising results, with some patients reported to improve markedly and some evidence of graft survival noted on positron emission tomography (PET). Host tissue recovery appears to be an important mechanism for this clinical improvement. The optimal technique is to use three to four fetuses from induced abortions of 6.5 to 8 weeks gestation, with multiple stereotactic implants into the putamen and caudate nucleus. Many biological questions still remain and the community remains troubled by the ethical problems of using fetal tissue obtained from abortions. This procedure is still experimental and should be restricted to a few centres with excellence in cell and molecular biology. A multicentre study is needed to more carefully evaluate CNS transplantation. Cloned neural precursor cells or immortalized embryonic cell lines genetically modified to manufacture selected growth factors or neurotransmitters may offer an alternative to the use of human fetal tissue. Much more experimental animal research is necessary before transplantation can be used to treat other CNS maladies. 相似文献
73.
From July 1989, to June 1996, 160 patients with congenital bile duct dilatation (CBD) were treated at our institution. The
incidence of CBD at our institution has increased annually. In approximately 90% of patients with CBD there was associated
anomalous arrangement of the pancreaticobiliary ductal system, and we concluded that this was one of the main causes of CBD.
Pediatric endoscopic retrograde cholangiopancreatography was first introduced to China in 1989, and has been successfully
performed in 90.2% of 92 patients at our institution. We found that age at diagnosis was closely related to the subtype, complications,
and mortality of CBD. The subtype also correlated with the presenting symptoms. One hundred and forty-seven of the 160 patients
underwent surgery. Of these 147 patients, 136 (92.5%) were cured with normal liver function and 9 (6.1%) improved with liver
impairment. Two patients died, one of postoperative pneumonia and one of liver failure. We conclude that early radical surgery
and careful postoperative follow-up are essential in the prevention of CBD complications such as cholangitis, pancreatitis,
biliary stones, and development of carcinoma.
This article is based on a special lecture delivered before the 19th meeting of the Japanese Society of Pancreatico-biliary
Maljunction, on September 14, 1996, in Tokyo 相似文献
74.
Pierre Pradat 《Genetic epidemiology》1994,11(2):131-140
During the period 1981–1986, 1605 infants presenting a major congenital heart defect (CHD) were identified in Sweden. Using the personal identification numbers of the mothers, 1507 of them could be linked to the Medical Birth Registry and two controls were selected for each infant. For this total of 4521 infants, 2686 postoccurrence sibs born during the period 1981–1989 were identified from the Medical Birth Registry. The tendency to have one or more sibs was higher among cases than among controls and was correlated to the life status of the proband. This tendency did not vary according to the type of CHD when controlling for life status. The prevalence at birth of CHD was almost four times higher among sibs of CHD infants than among sibs of normal infants. The tendency to have a sib with an extracardiac malformation did not differ between CHD probands and normal probands. The importance of only including births occurring after the proband when evaluating recurrence risks is stressed. © 1994 Wiley-Liss, Inc. 相似文献
75.
Summary When a baby is born with a visible disfigurement, then parents need to adjust to the loss of the anticipated 'perfect' child and thus accept their baby. The impact of the birth on the parents is described in the context of a measure which identifies areas of potential difficulty. The two groups studied were parents of children with cleft palates and parents of children with congenital hand deficit. A wide range of adjustment was found. There was no significant difference between the two groups in terms of their overall adjustment, but there were individual differences in adjustment which did not relate to the severity or type of anomaly. The only significant variable found to relate to parental adjustment was perceived family support. 相似文献
76.
77.
Twenty-two percutaneous transluminal balloon valvuloplasty procedures were performed on 21 patients with congenital pulmonary valve stenosis. The peak systolic pressure gradient was immediately reduced from 79.1 +/- 7.4 to 22.2 +/- 1.8 mmHg, (P less than 0.0001) and follow-up cardiac catheterization at 5.3 +/- 0.4 months in 19 patients revealed no further significant change in gradient (23.5 +/- 3.2 mmHg). The best results were obtained when balloons larger than the pulmonary annulus were used, i.e. an immediate residual transvalvular gradient of 22.0 +/- 2.2 mmHg with a balloon/annulus ratio greater than 1, as opposed to 44.2 +/- 5.4 with a balloon/annulus ratio = 1 (P less than 0.001). The angiographically determined cusp thickness of the stenotic pulmonary valves was significantly greater than that of the control group of 24 patients without pulmonary valve stenosis (1.21 +/- 0.09 vs 0.59 +/- 0.02 mmHg, P less than 0.00001). The relationship between this parameter and the residual transvalvular gradient at follow-up was found to be significant (r = 0.77, P less than 0.001). It is concluded that balloon size is a determinant factor in achieving good results with percutaneous balloon valvuloplasty although cusp thickness, a factor to which scant regard has hitherto been paid, also plays a significant role in the residual transvalvular gradient measured at follow-up. 相似文献
78.
先天性一侧肺动脉缺如的电子束CT诊断 总被引:14,自引:0,他引:14
目的 评价电子束CT(EBCT)诊断先天性一侧肺动脉缺如的价值。方法 对经平片、超声心动图检查后拟诊为肺血管疾病或原发性肺动脉高压的患者行EBCT检查,EBCT诊断先天性一侧肺动脉缺如的11例患者入选,并与超声心动图、核素通气灌注扫描、心血管造影的检查结果作进一步的比较及评估。结果 单发一侧肺动脉缺如4例,均为女性成年人。合并多发心血管畸形7例,其中合并复杂畸形3例,均为男性儿童和左肺动脉缺如;合并单发心血管畸形4例,其中3例为右肺动脉缺如。结论 (1)儿童时期明确诊断的一侧肺动脉缺如多合并有心血管畸形,且左肺动脉缺如多见,成年人明确诊断的单发一侧肺动脉缺如多为右肺动脉缺如。(2)EBCT对先天性一侧肺动脉缺如的诊断有较高的实用价值,较之多普勒超声更为准确,与心血管造影各具独特优势,但EBCT为无创检查是其特点。 相似文献
79.
Hilmar H. Bijma Agnes van der Heide Hajo I. J. Wildschut 《European Clinics in Obstetrics and Gynaecology》2007,3(2):89-95
During the last few decades, the use of ultrasonography for the detection of fetal abnormalities has become widespread in
many industrialised countries. This resulted in a shift in timing of the diagnosis of congenital abnormalities in infants
from the neonatal period to the prenatal period. This has major implications for both clinicians and the couples involved.
In case of ultrasound diagnosis of fetal anomaly, there are several options for the obstetric management, ranging from standard
care to non-aggressive care and termination of pregnancy. This essay explores the context of both clinical and parental decision
making after ultrasound diagnosis of fetal abnormality, with emphasis on the Dutch situation. While normal findings at ultrasound
examination have strong beneficial psychological effects on the pregnant woman and her partner, the couple is often ill prepared
for bad news about the health of their unborn child in the case of abnormal findings. This is, in particular, true in settings
where ultrasonography for the detection of fetal abnormalities is offered as an integral part of antenatal care without appropriate
counselling. An important question is to what extent the couple should be supported in decision making when a fetal abnormality
is diagnosed. In this context, the parental perception of having a choice varies markedly. When parents consider end-of-life
decisions, they experience both ambivalent and emotional feelings. On the one hand, they are committed to their pregnancy,
while on the other hand, they want to protect their child, themselves and the family from the burden of severe disability.
These complex parental reactions have implications for the counselling strategy.
相似文献
Hajo I. J. WildschutEmail: |
80.
HALIL SAGLAM LEVENT BÜYÜKUYSAL NILGÜN KÖKSAL ILKER ERCAN ÖMER TARIM 《Pediatrics international》2007,49(1):76-79
BACKGROUND: The incidence of congenital hypothyroidism (CH) is expected to be elevated in iodine-deficient areas. In this study, the authors aimed to determine the incidence of transient and permanent CH in a large city which is known to be in the zone of moderate iodine deficiency. METHODS: Newborn babies in Bursa, Turkey, were screened by measurement of serum thyroid-stimulating hormone (TSH) obtained by heel prick. The babies who had a serum TSH >20 mIU/L were recalled for measurement of T4 and TSH in venous serum. RESULTS: A total of 11 770 newborns were screened over a period of 9 years. The incidence of CH was found to be 1/840. However, after excluding the transient cases, permanent CH was diagnosed in 1/2354. It was impossible to distinguish transient patients from permanent CH by initial laboratory tests (P > 0.05). The estimated power of the study in determining the incidence of CH in the population was 90% (P < 0.05). CONCLUSION: The authors conclude that the incidence of CH is very high in their population which warrants a country-wide neonatal screening program. Since transient cases cannot be distinguished and untreated transient hypothyroidism may also cause mental retardation, treatment must be started as early as possible with frequent monitoring to optimize the outcome and identify the transient patients. 相似文献