Chemotherapy in intracerebrally transplanted tumors induced with transplacental administration of ethylnitrosourea in rats

Summary Four tumors of the spinal cord were induced with ethylnitrosourea in rats by transplacental administration and transplanted into the brains of animals of the same strain. One of these intracerebrally grafted tumor lines (G-XIII) was followed up over the first 10 passages and treated with CCNU and other alkylating drugs. The results were compared with findings in an earlier established line (G-XII) in passage 12 and 59, which in the first instance was sensitive to CCNU. The CCNU application prolonged survival in treated animals in various treatment schedules in the first 10 intracerebrally grafted generations of the tumor up to 59%. Induction times of tumors became increasingly shorter. The susceptibility of early passages was similar in both lines. Its loss in late passages went together with diffuse growth of the tumor and reticulin fiber production. In addition, glial fibrillary acid protein expression and formation of intermediate filaments in perivascular tumor cells was lost.     

The chemotherapy of posterior Fossa tumors in childhood

Conventional therapy for brain tumors, consisting of neurosurgical intervention and radiotherapy, has not resulted in the successes achievable in other childhood malignancies. The role of adjuvant chemotherapy, well defined in many childhood cancers, has not yet contributed significantly to the treatment of children with brain tumors. Chemotherapy of recurrent tumors has produced regressions but no cures. The most active agents identified to date in the treatment of recurrent posterior fossa tumors include cisplatinum, cyclophosphamide and methotrexate. Future efforts will need to focus on the rational selection of drugs for study in limited agent histology-stratified phase II trials, with advancement of active agents into large randomized phase III adjuvant therapy trials.     

Primary breast lymphoma.

Primary breast lymphoma (PBL) is a rare tumor of the breast. Three cases of PBL are being described. All three cases achieved remission following biopsy, chemotherapy, and/or radiotherapy. The literature is extensively reviewed with emphasis on true incidence of PBL and survival rates.     

卵巢浆液性肿瘤几种形态测量指标的比较

应用体视学方法对卵巢浆液性肿瘤进行研究，从定量的角度对卵巢良性、交界性及恶性肿瘤的五项指标进行比较，包括（１）细胞核长短轴之比；（２）结缔组织间质与上皮细胞体积密度之比；（３）细胞核与细胞浆体积密度之比（核浆比）；（４）细胞核平均直径；（５）乳头的上皮厚度。结果表明恶性肿瘤核浆体积密度比明显高于交界性及良性肿瘤（ｐ＜０．０１）；恶性肿瘤结缔组织间质与上皮细胞体积密度之比明显小于交界性及良性肿瘤（Ｐ＜０．０１）。     

Perioperative tumor localization for laparoscopic colorectal surgery

Background: Because of the inability to palpate colonic tumors during laparoscopy, their location must be precisely identified before resection is undertaken. Method: A retrospective study was performed of 58 patients in order to be able to describe our methods of tumor localization for laparoscopic colorectal operations and to review their effectiveness. Results: In all patients, the entire colon was examined preoperatively by colonoscopy. In one patient, preoperative colonoscopic localization was inaccurate. In 31 patients, tumors were easily detectable at surgery. In five patients with the tumor in the right colon, even though the lesion was not detectable at surgery, right colectomy was performed without marking because preoperative colonoscopy reliably identified the lesion adjacent to the ileocecal valve. Twenty-two patients required some type of procedure to localize the tumor. The procedures and their problems were as follows: preoperative tattoo (five)—tattoo not visualized (one); intraoperative colonoscopy alone (six), combined with intraoperative tattoo (four) or clip (three)—poor operative exposure due to bowel distension (nine), hard to see the clip (three), dislodged clip (two), inadequate resection margin (one); intraoperative proctoscopy alone (two), combined with laparoscopic stitch (two)—no problems. In no patient was tumor present at a resection line and in no patient was the wrong segment resected. Conclusions: Reliable preoperative identification of the tumor adjacent to the ileocecal valve can permit right colectomy without marking. Lesions in the upper rectum can be approached via intraoperative proctoscopy ± suture placement. If the surgeon anticipates intraoperative localization may be difficult, lesions other than rectal or cecal ones should probably be marked by preoperative tattooing. Further studies regarding the technique of tattooing are warranted. Received: 18 July 1996/Accepted: 10 March 1997     

恶性胃肠道间质瘤34例临床分析

目的探讨恶性胃肠道间质瘤临床、病理特点。方法回顾性分析2002—2004年收治的34例恶性胃肠道间质瘤的临床和病理资料。结果病人临床表现中腹痛与消化道出血较常见，发生部位最常见为小肠和胃；肿块平均直径10．2cm；术后均经病理学诊断为恶性。术后12例复发，4例死亡。结论肿瘤大小、位置、核分裂像、免疫组化指标是判断胃肠道间质瘤良、恶性的重要指标，对病人诊断为恶性或潜在恶性的胃肠道间质瘤必须进行包括手术治疗在内的综合治疗。     

彩色多普勒血流显像对肺良、恶性肿瘤鉴别诊断的应用

本文应用彩色多普勒血流显像技术对４０例肺肿瘤患者进行研究。全部病例均经手术及病理证实。结果表明：肺恶性肿瘤的内部及周边血流丰富，搏动指数（ＰＩ）和阻力指数（ＲＩ）低于肺良性肿瘤。因此，通过观察肺肿瘤的血流丰富程度及ＰＩ（界值＜１），ＲＩ（界值＜０．５）．可做为辨别肺恶性肿瘤的参考条件。     

Peritoneal Desmoplastic Small Round Cell Tumors with Divergent Differentiation: A Review

Peritoneal desmoplastic small round cell tumors with divergent differentiation are recently described highly aggressive neoplasms with characteristic clinical, morphologic, and immunohistochemical features. This review covers 38 cases that have been reported in the literature. The average age of patients is 18.4 years, and males are affected twice as frequently as females. Tumors generally present as multiple peritoneal nodules without obvious organ involvement. Histology shows islands of small cells set in dense desmoplastic stroma. Immunohistochemical stains are usually positive for cytokeratins, epithelial membrane antigen, desmin, and vimentin. Many cases also stain for neuron-specific enolase but rarely for other neuroepithelial markers. Ultrastructural appearances range from undifferentiated small cells to larger epithelial elements. Paranuclear aggregates of intermediate filaments are characteristic. Dense-core granules and other neuroendocrine features have been described in a minority of cases. Some tumors respond to chemotherapy, but most patients die within months to a few years. The histogenesis of these tumors is uncertain.     

纵隔软组织肿瘤23例临床病理分析

本科手术治疗纵隔软组织肿瘤２３例，占同期手术治疗纵隔肿瘤３９０例的５．９％，年龄３５岁以下者１７例，占７３．９％。男女之比为４．８：１（１９／４），本病的临床及Ｘ线表现缺乏特异性，确诊有赖于术后病理学检查。本组中良性肿瘤１５例（６５．２％），恶性肿瘤８例（３４．８％），手术治疗２４例次，肿瘤切除率为９１．７％（２２／２４），手术为首选的治疗方法。