不同手术参数对飞秒激光LASIK术后角膜知觉恢复的影响

目的探讨飞秒激光LASIK术中制瓣参数及切削参数的不同对术后中央角膜知觉恢复的影响。方法前瞻性实验研究。选取32例（64眼）行飞秒激光LASIK手术的近视患者,每例患者术前双眼屈光状态相近,飞秒激光制瓣参数选择随机设定一眼边切角90°,另一眼150°,角膜瓣厚度100 µm或110 µm,切削参数包括预设的光学治疗区直径和基质切削深度,然后行常规飞秒LASIK手术。采用广义线性模型分析边切角和角膜瓣厚度、光学治疗区直径和基质切削深度对术后中央角膜知觉的影响后,按不同基质切削深度分为3组：I组,<80 µm;II组,80~100 µm;III组,>100 µm。分别在术前,术后1周、1个月、3个月使用Cochet-Bonnet角膜知觉计检查中央角膜知觉。采用重复测量方差分析比较术前、术后各随访时间点及各组间在同一时间点的中央角膜知觉差异。结果术后1周、1个月中央角膜知觉与基质切削深度有关（B=-0.231、-0.247,P<0.05）,术后3个月与基质切削深度无关（B=-0.222,P>0.05）。术后1周、1个月、3个月中央角膜知觉与边切角度（B=-2.569、-3.993、-0.607,P>0.05）、角膜瓣厚度（B=-4.422、-11.058、-10.368,P>0.05）、光学治疗区直径（B=-3.515、-11.510、-9.058,P>0.05）均无关。术后1周、1个月、3个月中央角膜知觉较术前均明显下降（F=250.322,P<0.05）,但各组间在术后1周、1个月、3个月差异无统计学意义（F=2.092,P>0.05）。结论不同边切角、角膜瓣厚度和光学治疗区直径对术后角膜知觉的恢复无明显影响,切削深度对术后角膜知觉恢复有影响。     

Ex-press微型青光眼引流器植入联合生物羊膜植入术治疗原发性开角型青光眼

目的　观察Ｅｘ-ｐｒｅｓｓ微型青光眼引流器植入联合生物羊膜植入术与单纯Ｅｘ-ｐｒｅｓｓ微型青光眼引流器植入术治疗原发性开角型青光眼的效果。方法　根据手术方法不同,将原发性开角型青光眼患者４２例（７４眼）分为Ｅｘ-ｐｒｅｓｓ微型青光眼引流器植入联合生物羊膜植入术组（研究组）２５例４８眼和单纯Ｅｘ-ｐｒｅｓｓ微型青光眼引流器植入术组（对照组）１７例２６眼,观察术后前房、眼压、滤过泡、视力、手术成功率及并发症情况。结果　术后１周内发生浅前房者研究组为４眼（８．３３％）,对照组２眼（７．６９％）（χ２＝２．９７,Ｐ＞０．０５）。术后１周研究组眼压为（１２．１７±１．０２）ｍｍＨｇ（１ｋＰａ＝７．５ｍｍＨｇ）,对照组为（１２．６７±１．１４）ｍｍＨｇ（ｔ＝０．３７１,Ｐ＞０．０５）;术后１ａ研究组眼压为（１５．５３±２．６２）ｍｍＨｇ,对照组为（１９．６５±４．７１）ｍｍＨｇ（ｔ＝２．６４４,Ｐ＜０．０５）。２ａ后研究组总成功率为９５．８３％,对照组总成功率为６９．２３％（χ２＝５．９３,Ｐ＜０．０５）。术后１ａ研究组中功能性滤过泡占９３．７５％（４５／４８）,对照组占７３．０８％（１９／２６）,差异有统计学意义（Ｐ＜０．０５）。所有病例术后近期视力均不低于术前视力。研究组术后３０眼（６２．５％）出现并发症,对照组２１眼（８０．７７％）出现并发症,两组并发症发生率相比差异有统计学意义（Ｐ＜０．０５）。两组均未发生脉络膜脱离、低眼压性黄斑水肿等严重并发症。结论　Ｅｘ-ｐｒｅｓｓ微型青光眼引流器植入联合生物羊膜植入术治疗原发性开角型青光眼手术成功率高,术后并发症少,远期眼压控制效果好。     

Beta角评价前牙反患者颌骨矢状关系的准确性分析

目的探讨Beta角判断替牙期与恒牙期前牙反[牙合]患者颅面矢状关系的可靠程度。方法应用X线头颅定位侧位片,比较替牙期与恒牙期前牙反[牙合]患者的Beta角、ANB角、Wits值和APDI指数的差异,并进行相关性和变异程度分析。结果替牙期与恒牙期前牙反[牙合]患者Beta角间差异有统计学意义（P〈0．05）;Beta角与ANB角、Wits值和APDI指数显著相关（P〈0．05）,但变异较ANB角和Wits值小,与APDI指数接近。结论Beta角可准确评价前牙反[牙合]患者的颌骨矢状关系。     

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目的探讨数字根尖片在术前评估根管内折断器械取出难度和根管侧穿发生中的应用价值。方法应用分角投照技术拍摄的患牙数字根尖片,对2007年4月至2008年10月于烟台市口腔医院特需门诊就诊接受显微超声取根管内折断器械的病例47例进行分析,分析其折断器械在根管内的位置与折断器械取出成功率和根管侧穿发生率的关系。结果当折断器械位于根尖1/3时,应用显微超声技术取出的成功率和根管侧穿发生率分别为36.84%和52.63%,而器械位于根管冠1/3、中1/3时取出成功率分别为90.00%、88.89%,根管侧穿发生率分别为10.00%、11.11%;当折断器械位于弯曲根管以上或以下时器械取出的成功率分别为88.46%和42.86%,根管侧穿的发生率分别为11.54%和47.62%。结论分角投照数字根尖片在术前分析根管内折断器械取出的成功率和根管侧穿的发生具有较高的参考价值,可作为根管内折断器械病例术前难度评估和预测侧穿发生的常规方法。     

Wettability of denture relining materials under water storage over time

STATEMENT OF PROBLEM

Poor wettability of denture relining materials may lead to retention problems and patient discomfort.

PURPOSE

Purpose of this study is to compare and evaluate wettability of nine denture relining materials using contact angle measurements under air and water storage over time.

MATERIAL AND METHODS

Nine denture relining materials were investigated in this study. Two heat-curing polymethyl-methacrylate (PMMA) denture base materials: Vertex RS, Lang, one self-curing polyethyl-methacrylate (PEMA) chairside reline resin: Rebase II, six silicone relining materials: Mucopren soft, Mucosoft, Mollosil® plus, Sofreliner Touch, GC Reline™ Ultrasoft, Silagum automix comfort were used in this experiment. Contact angles were measured using high-resolution drop shape analysis system (DSA 10-MK2, KRUESS, Germany) under three conditions (in air after setting, 1 hour water storage, and 24 hours water storage). Nine materials were classified into three groups according to material composition (Group 1: PMMA, Group 2: PEMA, Group 3: Silicone). Mean values of contact angles were compared using independent samples t-test and one-way ANOVA, followed by a Scheffe''s post hoc analysis (α= 0.01).

RESULTS

Contact angles of materials tested after air and water storage increased in the following order: Group 1 (PMMA), Group 2 (PEMA), Group 3 (Silicone). Heat-cured acrylic denture base resins had more wettability than silicone relining materials. Lang had the highest wettability after 24 hours of water storage. Silicone relining materials had lower wettability due to their hydrophobicity. Wettability of all denture relining materials, except Rebase II and Mollosil® plus, increased after 24 hours of water storage.

CONCLUSIONS

Conventional heat-cured resin showed the highest wettability, therefore, it can be suggested that heat-cured acrylic resin is material of choice for denture relining materials.     

The impact of joint angle and movement velocity on sex differences in the functional hamstring/quadriceps ratio

Background

Females are two to eight times more likely to suffer a non-contact injury compared with males thus the purpose of this study was to explore the influence of joint angle and movement velocity on sex differences in the functional hamstring to quadriceps ratio (H/Q_FUNC).

Influence of Biodegradable Release Oils on the Physical and Mechanical Properties of Light-Colored Architectural Concrete

In the article, unique formulations of biodegradable, non-toxic, edible oil-based release oils were developed and tested on architectural concrete. The produced agents have physicochemical properties similar to diesel fuel, but at the same time, are renewable and biodegradable products. An ultrasound was used to properly combine the liquid phase of edible oil and the liquid phase of glyceryl trioleate and/or water. Based on the PN-B-19305 standard, seven-component configurations were designed and then tested. The wettability of the concrete was determined by contact angle (CA) analysis. After the application of the formulations produced, the architectural concrete still had good wettability. The vapor permeability test showed that the tested release agents did not inhibit water vapor diffusion from the tested samples. The O65G35 (65% unique edible oil formula and 35% glyceryl trioleate) concrete had the best absorption. In this case, the CA was 56° after oil application and 46° before. The new agents did not impair the adhesion of the plaster to concrete. The O90W10 concrete showed the best adhesion of plasters made with it—51.9 kN/m². The study also showed that the concrete surface had excellent paint absorption despite the use of release agents. The architectural concrete was evenly covered with paint without any problem. There were no difficulties in applying it, e.g., greasy places preventing the concrete from being coated with emulsion. The suitability of the produced release oils for lightweight architectural concrete structures intended for facades was confirmed. The best results were obtained after using formulations O65T35 and O90W10.     

低位直肠癌超低位吻合保肛术48例疗效评价

目的　评价低位直肠癌超低位吻合保肛术的安全性及临床价值。　方法　回顾性分析 4 8例低位直肠癌 ,行根治性全直肠切除后 ,重建直肠瓣、直肠角 ,用常规缝合法作乙状结肠与肛管齿状线或直肠最低位吻合。　结果　全组无手术死亡病例 ,术后出现吻合口狭窄 1例 ,肛周粪渍性湿疹 18例 (18/ 4 8) ,无其它并发症。术后 6个月肛门功能全部优良。局部复发率 6 2 5 % (3/ 4 8)。　结论　只要严格掌握适应证 ,超低位直肠癌保肛术是一种安全有效的方法 ,值得在临床上进一步研究和推广     

Using drug-excipient interactions for siRNA delivery

SiRNA is the trigger of RNA interference, a mechanism discovered in the late 1990s. To release the therapeutic potential of this versatile but large and fragile molecule, excipients are used which either interact by electrostatic interaction, passively encapsulate siRNA or are covalently attached to enable specific and safe delivery of the drug substance. Controlling the delicate balance between protective complexation and release of siRNA at the right point and time is done by understanding excipients-siRNA interactions. These can be lipids, polymers such as PEI, PLGA, Chitosans, Cyclodextrins, as well as aptamers and peptides. This review describes the mechanisms of interaction of the most commonly used siRNA delivery vehicles, and looks at the results of their clinical and preclinical studies.     

Hangman骨折19例手术治疗效果分析

目的 探讨Hangman骨折的治疗方法及疗效.方法 我院2005年1月～2010年12月分别采用前路手术内固定和后路手术内固定治疗Hangman骨折19例.结果 19例均获随访,随访时间6个月～3年,采用美国脊椎损伤协会(ASIA)评分标准分级评定神经功能恢复情况,术前有神经功能障碍者均恢复到E级,术后X线检查示椎间高...