全文获取类型
收费全文 | 488238篇 |
免费 | 36535篇 |
国内免费 | 14202篇 |
专业分类
耳鼻咽喉 | 4289篇 |
儿科学 | 9096篇 |
妇产科学 | 6698篇 |
基础医学 | 67401篇 |
口腔科学 | 12871篇 |
临床医学 | 42556篇 |
内科学 | 72782篇 |
皮肤病学 | 8406篇 |
神经病学 | 31485篇 |
特种医学 | 15573篇 |
外国民族医学 | 127篇 |
外科学 | 47562篇 |
综合类 | 65609篇 |
现状与发展 | 73篇 |
一般理论 | 14篇 |
预防医学 | 29695篇 |
眼科学 | 7944篇 |
药学 | 49097篇 |
174篇 | |
中国医学 | 26121篇 |
肿瘤学 | 41402篇 |
出版年
2023年 | 6407篇 |
2022年 | 8692篇 |
2021年 | 18886篇 |
2020年 | 15906篇 |
2019年 | 19005篇 |
2018年 | 19357篇 |
2017年 | 18249篇 |
2016年 | 16010篇 |
2015年 | 16435篇 |
2014年 | 23797篇 |
2013年 | 29211篇 |
2012年 | 23839篇 |
2011年 | 27276篇 |
2010年 | 20453篇 |
2009年 | 19826篇 |
2008年 | 21846篇 |
2007年 | 22947篇 |
2006年 | 21022篇 |
2005年 | 19220篇 |
2004年 | 16691篇 |
2003年 | 14897篇 |
2002年 | 12069篇 |
2001年 | 10878篇 |
2000年 | 8998篇 |
1999年 | 7998篇 |
1998年 | 6992篇 |
1997年 | 6836篇 |
1996年 | 6088篇 |
1995年 | 5509篇 |
1994年 | 5131篇 |
1993年 | 4210篇 |
1992年 | 3803篇 |
1991年 | 3496篇 |
1990年 | 2911篇 |
1989年 | 2605篇 |
1988年 | 2505篇 |
1987年 | 2096篇 |
1986年 | 1963篇 |
1985年 | 5319篇 |
1984年 | 5484篇 |
1983年 | 4340篇 |
1982年 | 4973篇 |
1981年 | 4298篇 |
1980年 | 3700篇 |
1979年 | 3362篇 |
1978年 | 2700篇 |
1977年 | 2090篇 |
1976年 | 2487篇 |
1975年 | 1794篇 |
1974年 | 1544篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
101.
Vincenzo Levi Andrea Franzini Andrea Di Cristofori Giulio Bertani Mauro Pluderi 《The journal of spinal cord medicine》2020,43(5):714-718
Context: Treatment of primary spinal syringomyelia is still controversial. Among others, shunting syrinx fluid to the subarachnoid, peritoneal or pleural space has been utilized with varying success. Shunt obstruction, migration, and infection represent the most common complications of these procedures. Findings: The authors present the case of an 81-year-old woman who developed an unusual neurological deterioration resembling a subacute posttraumatic ascending myelopathy (SPAM) after the insertion of a syringosubarachnoid shunt for the treatment of slow-growing D10 syringomyelia. Conclusion/Clinical Relevance: To date, no cases of SPAM secondary to the insertion of a syringosubarachnoid shunt for the treatment of syringomyelia have been reported. The potential pathogenesis related to this phenomenon is discussed. 相似文献
102.
《Clinical neurophysiology》2020,131(7):1444-1452
ObjectiveTo investigate cognitive functions in non-demented patients with early-onset Parkinson's disease (PD), and to compare PARK2 gene mutation carriers and non-carriers by means of event-related brain potentials (ERPs).MethodsThe participants comprised patients with early-onset PD (EOPD) and healthy controls (HC). Patients with EOPD were divided into two groups as carriers of known pathogenic variants of PARK2 gene (EOPD-PC) and non-carriers of genes involved in familial PD (EOPD-NC). ERP data were collected during auditory oddball and visual continuous performance test (CPT).ResultsBoth EOPD groups (EOPD-PC and EOPD-NC) displayed reduced and delayed P3 in response to oddball target and CPT NoGo. CPT Go P3 was reduced in EOPD-NC but not in EOPD-PC. Oddball target N1 was reduced and P2 was enhanced in both EOPD-PC and EOPD-NC. In both cognitive tasks, RTs were prolonged and accuracy was lower in EOPD-PC and EOPD-NC.ConclusionsWe found several EOPD-related neurophysiologic changes, implying impairments in cognitive functions. Pairwise comparisons between EOPD-PC and EOPD-NC revealed no significant ERP marker.SignificanceIn this study, the confounding effect of normative aging was somewhat excluded compared with many previous studies. In contrast with the many oddball studies in non-demented PD, we clearly observed reduced and prolonged P3 in early-onset PD. Our NoGo P3 findings also contribute to the limited ERP research concerning response inhibition. 相似文献
103.
《Neuro-Chirurgie》2022,68(4):414-425
Intraoperative monitoring of cerebral blood flow (CBF) has become an invaluable adjunct to vascular and oncological neurosurgery, reducing the risk of postoperative morbidity and mortality. Several technologies have been developed during the last two decades, including laser-based techniques, videomicroscopy, intraoperative MRI, indocyanine green angiography, and thermography. Although these technologies have been thoroughly studied and clinically applied outside the operative room, current practice lacks an optimal technology that perfectly fits the workflow within the neurosurgical operative room. The different available technologies have specific strengths but suffer several drawbacks, mainly including limited spatial and/or temporal resolution. An optimal CBF monitoring technology should meet particular criteria for intraoperative use: excellent spatial and temporal resolution, integration in the operative workflow, real-time quantitative monitoring, ease of use, and non-contact technique. We here review the main contemporary technologies for intraoperative CBF monitoring and their current and potential future applications in neurosurgery. 相似文献
104.
105.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献106.
107.
Filomena Napolitano Valentina Di Iorio Giuseppe Di Iorio Mariarosa Anna Beatrice Melone Fernando Gianfrancesco Francesca Simonelli 《Ophthalmic genetics》2019,40(1):39-42
Background: Extracellular matrix molecular components, previously linked to multisystem syndromes include collagens, fibrillins and laminins. Recently, we described a novel multisystem syndrome caused by the c.9418G>A p.(V3140M) mutation in the laminin alpha-5 (LAMA5) gene, which affects connective tissues of all organs and apparatus in a three generation family. In the same family, we have also reported a myopic trait, which, however, was linked to the Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) gene. Results of investigation on vitreous changes and their pathogenesis are reported in the present study.Materials and Methods: Nineteen family individuals underwent complete ophthalmic examination including best-corrected visual acuity (BCVA), fundus examination, fundus photography, intraocular pressure measurement, axial length measurement using ocular biometry, Goldmann visual field examination, standard electroretinogram, SD-OCT. Segregation analysis of LAMA5 and P4HA2 mutations was performed in enrolled members.Results: The vitreous alterations fully segregated with LAMA5 mutation in both young and adult family members. Slight reduction of retinal thickness and peripheral retinal degeneration in only two patients were reported.Conclusions: In this work we showed that PVD is a common trait of LAMA5 multisystem syndrome, therefore occurring as an age-unrelated trait. We hypothesize that the p.(V3140M) mutation results in a reduction of retinal inner limiting membrane (ILM) stability, leading to a derangement in the macromolecular structure of the vitreous gel, and PVD. Further investigations will be necessary to elucidate the role of wild type and mutated LAMA5 in the pathogenesis of PVD. 相似文献
108.
109.
目的:探究翁连解毒汤治疗浊毒内蕴型溃疡性结肠炎(Ulcerative Colitis,UC)临床疗效及可能的作用机制。方法:选取2016年2月至2018年12月在攀枝花学院附属医院收治的浊毒内蕴型UC患者130例作为研究对象,按照入院先后顺序分为对照组和观察组,每组65例。对照组常规西医治疗,观察组加用翁连解毒汤,观察2组治疗前、完成治疗后T细胞、NK细胞、炎性反应因子、凝血功能、生命质量变化,完成治疗后总结疗效。结果:观察组患者在NK细胞、T淋巴细胞组成、CR、TNF-α、IL-1 β、ESR、内毒素、IL-10、FIB、PLT、APTT改善方面的效果较对照组更优,组间差异有统计学意义(P<0.05)。观察组患者完成治疗后的生命质量量表各维度评分及总评分改善效果优于对照组患者(P<0.05),且临床总有效率和组织病理学疗效率均高于对照组患者(P<0.05)。结论:翁连解毒汤能抑制浊毒内蕴型UC炎性反应,改善高凝状态,提高机体免疫功能,从而提高疗效和生命质量。 相似文献