彩色多普勒超声对桥本氏甲状腺炎与Graves病鉴别诊断的价值

目的探讨彩色多普勒超声对于桥本氏甲状腺炎与Graves病鉴别诊断的价值。方法应用二维及彩色多普勒超声对30例桥本氏甲状腺炎患者、30例Graves病患者进行甲状腺检查,并与30例正常对照组比较。结果 Graves病患者甲状腺上动脉收缩期峰值血流速度较桥本氏甲状腺炎明显升高,诊断界点80cm/s,鉴别诊断的灵敏度为80.0%,特异度为89.7%,ROC曲线下面积为0.84。结论彩色多普勒超声对于桥本氏甲状腺炎与Graves病的鉴别诊断具有实际意义。     

MSCT3D成像诊断颈部恶性肿瘤颈淋巴结转移的应用价值

目的探讨MSCT3D戍像诊断颈部恶性肿瘤颈淋巴结转移的诊断价值。方法本文回顾性分析了经手术病理证实的88例颈部恶性肿瘤颈淋巴结转移的MSCT3D戍像的cT表现及其临床特征。结果MScT3D戍像对诊断转移性颈部恶性淋巴结增大有较高的敏感性（95．45%）和特异性（85．7％）：颈部恶性肿瘤颈淋巴结转移与其原发灶之间有一定的规律性。结论MscT3D成像可作为诊断颈部恶性肿瘤侵犯颈淋巴结的一项重要的检查方法,MscT能较好地显示颈淋巴结转移的引流特征与影像特征,两者问具有密切的关系。     

超声弹性成像与彩色能量多普勒在鉴别乳腺肿块中的临床应用

目的 探讨超声弹性成像与彩色能量多普勒在鉴别乳腺肿块良恶性中的应用价值.方法 72例乳腺肿块病人(87个病灶),术前经超声弹性成像及彩色能量多普勒超声检测,并给予相应评分,和术后病理结果对比分析.结果 彩色能量多普勒检测乳腺肿块恶性的阳性率高于超声弹性成像.结论 超声弹性成像能够依据乳腺肿块的相对硬度判断乳腺肿块的良恶性质,彩色能量多普勒依据乳腺肿块内的血流丰富程度判断其良恶性质,二者联合应用能够提高超声检查判断乳腺肿块良恶性的准确度.     

样本量估计与检验效能分析(六)

所谓单因素多水平设计,是指试验中仅涉及一个具有k个水平(k≥3)的试验因素,未对其他任何重要非试验因素进行有计划的安排.本文向读者介绍单因素多水平设计一元定量资料与结果变量为二值变量的单因素多水平设计一元定性资料的样本含量与检验效能估计.     

样本量估计与检验效能分析（六）

所谓单因素多水平设计,是指试验中仅涉及一个具有尼个水平（k≥3）的试验因素,未对其他任何重要非试验因素进行有计划的安排。本文向读者介绍单因素多水平设计一元定量资料与结果变量为二值变量的单因素多水平设计一元定性资料的样本含量与检验效能估计。     

30例食管癌适形放疗疗效观察

目的探讨食管癌适形放疗的临床疗效,分析患者的急性放射性损伤情况,为适形放疗的临床应用提供参考。方法选择2006年1月-2009年12月我院收治的30例食管癌患者进行三维适形放疗,随机挑选30例食管癌患者作为对照组进行常规放疗。对两组患者1—3年生存率及急性放射性损伤情况进行随访观察和分析。结果两组患者1年生存率、2年生存率差异均无统计学意义（P〉0.05）。适形放疗组患者的3年生存率显著高于对照组（P〈0.05）。两组患者均顺利完成整个化疗进程。适形放疗组患者有2例发生Ⅰ级食管放射损伤,1例发生Ⅱ级食管放射损伤,1例发生Ⅲ级食管放射损伤,1例发生肺部放射损伤,未有患者发生放射性肺炎,有4例患者发生放射性气管炎,适形放疗组患者的急性放射性损伤发生率较低,但两组患者的急性放射性损伤发生率差异无统计学意义。结论三维适形放疗可提高食管癌患者的生存率,并减少放疗的损伤,更有利于患者的接受。     

Multiple spectroscopic studies on the interaction between olaquindox,a feed additive,and bovine serum albumin

The interaction between olaquindox (OLA) and bovine serum albumin (BSA) was investigated using fluorescence, UV–vis absorption and circular dichroism (CD) spectroscopy. The results showed that the fluorescence quenching of BSA by OLA was a static quenching process induced by the formation of OLA–BSA complex. The binding constant of OLA–BSA complex was calculated to be 1.299 × 10⁴ L mol⁻¹ (293 K). The negative values of ΔH⁰ and ΔS⁰ indicated that hydrogen bond and van der Waals interactions played major roles in stabilizing the complex. Site probe competition experiments and number of binding sites (n) revealed that OLA could bind to site I in subdomain IIA of BSA, and the binding distance (r) was evaluated to be 3.643 nm according to Förster’s non-radiative energy transfer theory. The results of CD and three-dimensional fluorescence spectra suggested some conformational changes of BSA after OLA binding.     

The natural outcome of melamine-induced bladder stones with bladder epithelial hyperplasia after the withdrawal of melamine in mice

The natural outcome of melamine-induced bladder stones (cystoliths) with bladder epithelial hyperplasia (BEH) after melamine withdrawn is unclear. Using an ideal dual-model system, three experiments were conducted in BALB/c mice. Each experiment included a control, model 1 and model 2 groups. The mice were fed a regular diet in controls or a 9373 ppm melamine diet in models, and the first day was designated as dosing day 1. The melamine diet was then replaced by the regular diet in the model 2 groups, and the first day was designated as post-dosing day 1. On dosing days 12, 35 and 49, the incidence of cystoliths and diffusely active BEH was 8/8 in the mice of three model 1 groups. On post-dosing days 1, 4 and 8, in the mice of three model 2 groups, the incidence of cystoliths was 2/8, 0/8 and 1/8, respectively, and the progressive regression of BEH was observed. In conclusion, both the stones and BEH have the natural property of rapid development and rapid regression, and melamine withdrawn plays a key role in the stone dissolution-discharge necessary for BEH regression. BEH may be reversible after the discharge of the stones. The conventionally conservative therapy is thus reasonable.     

二维超声和彩色多普勒血流显像对乙型肝炎肝纤维化的诊断价值

目的 探讨二维超声和彩色多普勒血流显像对乙型肝炎肝纤维化的临床诊断意义.方法 将202例慢性乙型肝炎肝纤维化患者按照肝脏穿刺活检组织学将其分为4期,分别为S0(28例),S1(57例),S2(65例)和S3(52例)期.采用彩色多普勒超声检测仪对患者门静脉血流动力学指标进行分析.结果 肝纤维化S1～S3期患者门静脉、脾静脉以肠系膜上静脉内径(Dpv、Dsv、Dsmv)均明显大于S0期[分别为(1.48±0.19)、(1.52±0.25)、(1.98±0.26) cm比(1.05±0.22) cm,(1.17±0.25)、(1.38 ±0.31)、(1.62±0.34)cm比(0.81±0.24)cm,( 1.28±0.25)、(1.65±0.61)、(1.87±0.57)cm比(0.99 ±0.21 )cm];门静脉和肠系膜上静脉血流速度(Vsmv、Vsv)明显低于S0期[(18±5)、(14±4)、(12±4) cm/s比(25±5)cm/s,(20±6)、(17±7)、(14±7)cm/s比(32±7) cm/s];门静脉和脾静脉血流量(Qpv、Qsv)明显高于S0期[ (747±1801)、(951±152)、(1010±143)ml/min比(667±167) ml/min,( 648±229)、(758±201)、( 856±214) ml/min比(265±135)ml/min],而肠系膜上静脉血流量(Qsmv)明显低于S0期[(625±132)、(599±112)、(535±150)ml/min比(755±102) ml/min];以上差异均有统计学意义(P＜0.05或P＜0.01),并随着患者肝纤维化程度的加重变化加剧.结论 彩色多普勒超声对乙型肝炎肝纤维化诊断具有重要的价值.     

酚酞及其试纸变色性能的观测

目的 观测酚酞及其试纸在碱性区域的pH分辨能力.方法 紫外可见分光光度法和色差计法.结果 碱性溶液中酚酞在553 nm处的吸光度随pH值增加而加大,pH14时快速褪色.酚酞试纸在pH8 ～ 14区间相邻pH值之间的色差较大.结论 可按相邻pH值之间吸光度之差或色差的大小判断酚酞和酚酞试纸的pH分辨能力.可用酚酞试纸和配套使用的比色版检测碱性溶液的pH值.