全文获取类型
收费全文 | 37982篇 |
免费 | 2386篇 |
国内免费 | 1269篇 |
专业分类
耳鼻咽喉 | 85篇 |
儿科学 | 975篇 |
妇产科学 | 687篇 |
基础医学 | 2011篇 |
口腔科学 | 69篇 |
临床医学 | 4423篇 |
内科学 | 11246篇 |
皮肤病学 | 53篇 |
神经病学 | 1174篇 |
特种医学 | 917篇 |
外科学 | 2722篇 |
综合类 | 7544篇 |
现状与发展 | 5篇 |
预防医学 | 1937篇 |
眼科学 | 744篇 |
药学 | 5009篇 |
31篇 | |
中国医学 | 1638篇 |
肿瘤学 | 367篇 |
出版年
2024年 | 41篇 |
2023年 | 481篇 |
2022年 | 701篇 |
2021年 | 1305篇 |
2020年 | 1329篇 |
2019年 | 1123篇 |
2018年 | 1210篇 |
2017年 | 1150篇 |
2016年 | 1247篇 |
2015年 | 1264篇 |
2014年 | 2593篇 |
2013年 | 3444篇 |
2012年 | 2083篇 |
2011年 | 2153篇 |
2010年 | 1877篇 |
2009年 | 1704篇 |
2008年 | 1639篇 |
2007年 | 1826篇 |
2006年 | 1619篇 |
2005年 | 1376篇 |
2004年 | 1250篇 |
2003年 | 1151篇 |
2002年 | 961篇 |
2001年 | 938篇 |
2000年 | 799篇 |
1999年 | 666篇 |
1998年 | 569篇 |
1997年 | 609篇 |
1996年 | 507篇 |
1995年 | 532篇 |
1994年 | 450篇 |
1993年 | 311篇 |
1992年 | 327篇 |
1991年 | 269篇 |
1990年 | 233篇 |
1989年 | 201篇 |
1988年 | 215篇 |
1987年 | 182篇 |
1986年 | 163篇 |
1985年 | 211篇 |
1984年 | 193篇 |
1983年 | 90篇 |
1982年 | 120篇 |
1981年 | 123篇 |
1980年 | 126篇 |
1979年 | 63篇 |
1978年 | 46篇 |
1977年 | 50篇 |
1976年 | 48篇 |
1975年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Rafiye Ciftciler Haluk Demiroglu Yahya Buyukasık Elifcan Aladag Salih Aksu Ibrahim C. Haznedaroglu Nilgun Sayınalp Osman Ozcebe Umit Yavuz Malkan Hakan Goker 《Clinical Lymphoma, Myeloma & Leukemia》2019,19(3):177-182
Background
Refractory acute myeloid leukemia (AML) includes AML includes failure of disease to respond to standard induction chemotherapy, relapse within 6 months after first CR, and 2 or more relapses. The outcome of these patients is usually very poor; only a small proportion can be rescued by allogenic hematopoietic stem-cell transplantation (allo-HSCT). The aim of this study was to evaluate the efficacy and feasibility of allo-HSCT in patients with refractory AML.Patients and Methods
We retrospectively analyzed the clinical outcome of 91 patients who were diagnosed with treatment-refractory AML at Hacettepe University Hospital between January 2002 and June 2018. Patients' disease status included refractory AML, defined as failure to respond to standard induction chemotherapy and relapse within 6 months after first complete remission.Results
The median follow-up was 12 months (range, 0.5-184 months) for the entire group. Kaplan-Meier estimates of the 3-year overall survival for patients who underwent allo-HSCT and patients who received only salvage chemotherapy were 67% and 12%, respectively. Additionally, the Kaplan-Meier estimates of 5-year overall survival for patients who underwent allo-HSCT and patients who received only salvage chemotherapy were 44% and 4%, respectively (P < .001). Complete remission was obtained in 25 patients (83.3%) who underwent allo-HSCT; however, the disease of only 3 patients (3.8%) exhibited complete response after salvage chemotherapy.Conclusion
Allo-HSCT is still the best-known treatment option with curative potential in patients with treatment-refractory AML. Therefore, all efforts should be made in an attempt to find a suitable matched donor in order to perform allo-HSCT. 相似文献12.
Alexandra Katsimardou Konstantinos Imprialos Konstantinos Stavropoulos Alexandros Sachinidis Michalis Doumas 《Expert opinion on pharmacotherapy》2020,21(10):1241-1252
ABSTRACT
Introduction
Type 1 diabetes mellitus (T1DM) is a chronic, autoimmune disease that is characterized by total absence of insulin production. Hypertension is a common comorbidity in T1DM with complex pathophysiology, while it is also a well-recognized risk factor for the development of cardiovascular disease (CVD), as well as other microvascular diabetic complications. 相似文献13.
14.
目的探讨女性难治性膀胱过度活动症患者心理弹性状况及保护性因素,为改善其身心健康提供依据。方法采用心理弹性量表、症状自评量表、艾森克人格问卷、社会支持量表、焦虑及抑郁量表对80例女性难治性膀胱过度活动症患者进行问卷调查。结果女性难治性膀胱过度活动症患者心理弹性得分为(54.10±8.27)分,显著低于国内常模(P<0.05)。患者的一般情况(病程、年龄、文化程度)对心理弹性的预测作用不明显(R2=0.14,F=18.10),当社会支持、SCL-90、人格特质、SAS、SDS进入方程后,对患者的心理弹性具有较明显的预测作用(R2=0.67,△R2=0.46,F=115.22)。结论女性难治性膀胱过度活动症患者心理弹性较差,社会支持、SCL-90、人格特质、焦虑抑郁情绪是其重要的影响因素,应重视患者存在的心理问题,发掘心理弹性的保护性因素并积极干预,促进其身心健康。 相似文献
15.
16.
17.
18.
目的 研究血清窖蛋白-1 (Cav-1) 在慢性阻塞性肺疾病 (COPD) 相关肺动脉高压 (PAH) 患者中的表达及其意义。方法 选取稳定期COPD患者65例, 根据是否合并PAH分成COPD组 [肺动脉收缩压 (PASP) <40 mmHg, 35例] 及COPD-PAH组 (PASP ≥40 mmHg, 30例)。另选取在本院健康体检的志愿者30例作为对照组。对比各组基线资料、 动脉血气分析、 肺功能指标, 以及血清Cav-1、 白细胞介素 (IL) -6和肿瘤坏死因子-α (TNF-α) 的表达水平。绘制受试者工作特征 (ROC) 曲线, 评价Cav-1对COPD合并PAH的诊断价值。结果 COPD-PAH组与COPD组第一秒用力呼吸容积 (FEV1) /用力肺活量 (FVC)、 FEV1占预计值百分比 (FEV1%) 及氧分压 [p (O2 )] 低于对照组, 而二氧化碳分压 [p (CO2 )]、 PASP均高于对照组 (P<0.01)。COPD-PAH组p (O2 ) 低于COPD组, p (CO2 )、 PASP均高于COPD 组 (P<0.01)。对照组、 COPD组及COPD-PAH组Cav-1表达水平呈逐渐降低趋势, 而IL-6、 TNF-α表达水平呈逐渐升高趋势 (P<0.01)。血清Cav-1诊断COPD合并PAH的ROC曲线下面积为0.902 (0.821~0.955), 最佳截断值为 6.66 μg/L, 此时诊断敏感度为76.7%, 特异度为85.7%, 与多普勒超声诊断仪测量PASP结果比较一致性较好 (Kappa 值=0.627)。结论 血清Cav-1在COPD相关PAH患者表达明显下调, 可以作为预测COPD相关PAH的新型血清标志物。 相似文献
19.
《Clinical neurophysiology》2019,130(1):128-137
ObjectiveHigh frequency oscillations (HFO) between 80–500 Hz are markers of epileptic areas in intracranial and maybe also scalp EEG. We investigate simultaneous recordings of scalp and intracranial EEG and hypothesize that scalp HFOs provide important additional clinical information in the presurgical setting.MethodsSpikes and HFOs were visually identified in all intracranial scalp EEG channels. Analysis of correlation of event location between intracranial and scalp EEG as well as relationship between events and the SOZ and zone of surgical removal was performed.Results24 patients could be included, 23 showed spikes and 19 HFOs on scalp recordings. In 15/19 patients highest scalp HFO rate was located over the implantation side, with 13 patients having the highest scalp and intracranial HFO rate over the same region. 17 patients underwent surgery, 7 became seizure free. Patients with poor post-operative outcome showed significantly more regions with HFO than those with seizure free outcome.ConclusionsScalp HFOs are mostly located over the SOZ. Widespread scalp HFOs are indicative of a larger epileptic network and associated with poor postsurgical outcome.SignificanceAnalysis of scalp HFO add clinically important information about the extent of epileptic areas during presurgical simultaneous scalp and intracranial EEG recordings. 相似文献
20.