Middle turbinate osteoma

A 14-year-old female patient presented with six months history of progressive nasal obstruction on the left side associated with ipsilateral facial pain. Radiograph of the nose and paranasal sinuses showed a bony mass arising from the left lateral nasal wall. Under general anesthesia left lateral nasal wall is approached through a modifi ed Lynch incision. A bony mass arising from the ant part of the middle turbinate was removed. Histopathological examination of the resected specimen showed picture of an osteoma. The postoperative course was uneventful.     

经鼻持续正压通气治疗阻塞性睡眠呼吸暂停综合征的依从性及其影响因素分析

目的了解经鼻持续正压通气(nCPAP)治疗阻塞性睡眠呼吸暂停综合征(OSAS)的依从性及其影响因素。方法对经nCPAP治疗的31例OSAS患者进行随访调查,分析性别、年龄、职业、居住地、教育程度、烟酒嗜好、病程、对疾病的认识程度、家族史、就医条件、治疗前后临床表现、治疗时间、nCPAP治疗压力以及使用呼吸机过程中出现副作用等因素,结合对治疗效果的自我评价和睡眠监测资料等指标,计算其依从性,并用多元回归方法统计分析上述因素与依从性之间的关系。结果nCPAP治疗OSAS依从性为(8114±2547)%,以依从性为因变量,以上述因素为自变量作多元逐步回归分析,在α=005的水平上,进入回归方程的有4个因素,按作用强度大小依次为对疾病认识程度、打鼾程度、治疗效果自我评价和使用呼吸机过程中有无出现副作用及其他问题。结论nCPAP治疗OSAS有较高的依从性。患者对疾病认识程度、打鼾程度、治疗效果自我评价和使用呼吸机过程中有无出现副作用及其他问题对依从性有较大影响。     

鼻内镜下微创手术治疗内翻性乳头状瘤

目的：探讨鼻内窥镜下使用电动切割器微创手术治疗鼻腔鼻窦内翻性乳头状瘤的可行性及疗效。方法：鼻腔鼻窦内翻性乳头状瘤39例中12例前期有1—3次经鼻或鼻侧切开手术史。入院后常规鼻内窥镜及鼻窦CT检查，肿物局限于鼻腔(鼻甲、中隔、鼻道)者3例，单侧一窦或多窦受累者35例，双侧鼻窦受累者1例，均未发现眶内及颅内受侵。34例在局麻加强化麻醉下行鼻内镜微创手术，5例因广泛累及上颌窦加用鼻内镜下柯一陆氏手术，术中均用电刀电凝肿瘤基底部及可疑肿瘤残余处，全部病例均获随访2～60个月。结果：39例中2例术后复发，复发率为5．13％。1例术后1年复发，因累及眶内故在全麻下行鼻侧切开肿物切除术，手术病理报告为纤维肉瘤，建议放疗，患者自动出院失访。1例术后9个月复发，门诊复查时见中鼻道有肿瘤样物质，在内镜下用电动切割器切除肿瘤，用电刀电凝肿瘤基底部，病理报告为内翻性乳头状瘤，随访2年未复发。其余37例随访期间均未见复发。结论：鼻内窥镜手术治疗内翻性乳头状瘤具有术中出血少，创伤小，术后不留瘢痕，复发率低等优点，电动切割器微创手术具有对正常黏膜刺激小，手术范围准确，术后并发症少，鼻腔上皮化修复快等优点。对肿瘤广泛累及上颌窦者加用鼻内镜下柯-陆氏手术。对疑有恶变的患者采用鼻侧切开术。     

Immunohistochemical localization of c-myc oncogene product in oral papilloma

The expression of c-myc oncogene products in oral papillomas was studied by using an immunohistochemical method. The oncogene products were detected in 17(70.8%) of the 24 oral papillomas under study. The expression of the products was evaluated, and the histologic localization in proliferating epithelial cells of the oral papillomas was determined. In the basal cell layer, the products were detected in the nuclei of 16 oral papillomas, and in the cytoplasm of 12 oral papillomas. In the nuclei of cells in the spinous cell layer, the products were detected in 4 oral papillomas, and in the cytoplasm of 13 oral papillomas. In the keratinized cells, the products were not detected in the nuclei, but they were identified in the cytoplasm of three oral papillomas. The results suggested that the c-myc oncogene product might play an important role for proliferation and differentiation of the oral papilloma.     

鼻腔嗅神经母细胞瘤6例报告

目的 :探讨鼻腔嗅神经母细胞瘤的临床表现、病理、诊断、鉴别诊断及治疗。方法 :诊治鼻腔嗅神经母细胞瘤 6例 ,B期 4例 ,C期 2例 ,均行手术加放射治疗。结果 :B期患者 2年生存率 5 0 % ,3年生存率2 5 %。C期患者 2年生存率 5 0 % ,5年生存率 5 0 %。结论 :鼻腔嗅神经母细胞瘤B、C期患者手术加放疗是最佳的治疗方案     

Nasal intubation: A minimally obtrusive anosmia technique applied to rats

Nasal intubation represents a reversible, nonsurgical anosmia technique which produces little behavioral or physiological disruption. A polyethylene tube of sufficient length to extend from the narial opening past the various olfactory receptors is inserted into each nasal cavity. Thus, the animal can breathe freely through the tube, but the length of the tube prevents air from contacting olfactory receptors. To reverse the technique, the tubes are simply pulled out. The intubation technique was examined for the ability to produce anosmia with minimal nonolfactory behavioral disruption. Intubated animals lost the ability to perform olfactory discrimination, but completely regained olfactory discrimination ability once the tubes were removed. Controls for the effects of intubation on discriminative responding showed no deficit. Olfactory detection tests revealed intubated animals lost the ability to locate buried, scented food. Controls for the effects of intubation showed no deficit in olfactory detection. Open field tests, daily weight records, and subjective judgments of ease of handling, used to assess the secondary effects of intubation, showed no significant effect of intubation.     

Radiotherapy for inverted papilloma: a case report

Inverted papilloma is an infrequent tumour of the nasal cavity and paranasal sinuses associated with controversy. The incidence of carcinoma in situ associated with inverted papilloma, has not been very well documented until now. Therefore, we present a case report characterized by an aggressive clinical behaviour, treated by extensive surgery and ultimately controlled by radiotherapy.     

Koilocytotic lesions of the cervix: the interrelation of morphometric features, the presence of papillomavirus antigens, and the degree of koilocytosis

We studied the interrelation of morphometric features, the presence of human papilloma virus antigens (localized by the immunoperoxidase method), and the degree of koilocytosis in koilocytotic cervical intraepithelial neoplasia. We determined the morphometric features of the cells from the deep, the middle, and the superficial layers of the affected koilocytotic epithelium and in non-koilocytotic immature metaplasia and squamous cervical epithelium. This approach allows quantification of disturbances of maturation in cervical epithelium. Our quantitative findings support the contention of other authors that human papilloma virus infection is associated with a morphologically distinct lesion, which forms a morphological continuum with neoplasia. It can be argued that, in addition to the degree of koilocytosis, nuclear enlargement and excessive cellular enlargement in the middle layer of the affected epithelium are viral-related effects. With increasing immaturity of the cervical intraepithelial neoplasia all investigated viral-related changes are less prominent. These findings suggest that in neoplastic transformation the morphological and antigen expression of human papilloma virus infection is suppressed.     

舌乳头状瘤及鳞状细胞癌组织的PCNA及AgNOR表达

报告了国内首例bcr／abl反义核酸体外净化的慢性髓细胞白血病自体骨髓移植，净化后存留CFU－GM的bcr／ablmRNAPCR（－），移植后12月仍保持50％的Ph（－）造血重建，至今已无病生存30个月．反义核酸体外净化尚未见明显毒副作用．     

Salmon-calcitonin nasal spray in Paget's disease of bone: Preliminary results in five patients

Summary The effectiveness of Synthetic Salmon Calcitonin (SSCT) administered as a nasal spray was assessed via clinical, biological, and radiological variables in 5 Pagetic patients during a 6 months course therapy, the results show that intranasal administration does not decrease the activity of SSCT in Paget's disease of bone.