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41.
42.
《Néphrologie & thérapeutique》2021,17(6):473-474
Vitiligo is an acquired depigmenting disorder. Vitiligo universalis is a rare form responsible for significant aesthetic damage. To date, the exact pathogenesis remains unknown. Its treatment, a real challenge, consists rather in removing the still pigmented areas. We report a case of a patient followed for stable vitiligo universalis from an early age who presented with repigmentation shortly after initiation of hemodialysis. 相似文献
43.
《Vaccine》2021,39(18):2537-2544
BackgroundAlthough the efficacy of hepatitis B vaccines among hemodialysis patients has been documented, the long-term persistence of immunogenicity in this population remains largely unknown. We explored the long-term persistence of immunogenicity induced by different hepatitis B vaccine regimens in hemodialysis patients.MethodsIn initial study, we conducted a randomized, multicenter, double-blind, parallel-controlled trial among hemodialysis patients in 13 hospitals in Shanxi Province, China. A total of 352 hemodialysis patients were allocated to receive 3-dose 20 μg (IM20 group) and 3-dose 60 μg (IM60 group) recombinant hepatitis B vaccine at months 0, 1, and 6. Vaccine-induced immune responses were measured at month 7. In this study, the responders (anti-HBs ≥ 10 mIU/mL) were followed up at months 18, 24, 30, 36 and 42, respectively. We used the generalized log-rank test and generalized estimating equations (GEE) to analyze the long-term durability of responses and the kinetics of anti-HBs levels, respectively.ResultsA total of 284 patients were involved in the extended follow-up period. The duration of vaccine-induced response with 75% of patients maintained protective antibody were 12 months and 18 months in the IM20 group and IM60 group, respectively (P = 0.291). The long-term persistent immunogenicity induced by 3-dose 60 μg was more satisfactory than that by 3-dose 20 μg hepatitis B vaccine in patients with hemodialysis duration ≥ five years (P = 0.023). The peak anti-HBs levels in 100–1000 mIU/mL or ≥ 1000 mIU/mL were more likely to maintain long-term protective antibody compared to anti-HBs levels in 10–100 mIU/mL (P < 0.05). The kinetic profile was similar between the two groups (P = 0.334).ConclusionHigh-dose 60 μg hepatitis B vaccine could lead a satisfactory long-term durability of immunogenicity among patients with hemodialysis duration of five years or more. Peak anti-HBs level after vaccination was associated with the long-term persistence of immunogenicity. 相似文献
44.
Carlo Orzincolo M.D. Pier Luigi Bedani M.D. Pier Nuccio Scutellari M.D. Piero Cardona M.D. Francesco Trotta M.D. Paolo Gilli M.D. 《Skeletal radiology》1990,19(7):483-487
Nine patients undergoing regular dialytic treatment for more than 60 months showed clinical and radiologic features of a noninfective and destructive spondyloarthropathy. The cervical spine was most affected (100%), followed by the dorsal (three patients, 33.3%) and the lumbar spine (two patients, 22.2%). Typically, radiographs and CT scans revealed narrowing of intervertebral spaces, with destruction or sclerosis of the subchondral bone of the vertebral plate.Autopsy was performed on three patients; histologic study demonstrated the presence of large amyloid deposits containing
2-microglobulin (
2-m) in the discs and peridiscal ligaments.A radiographic follow-up of the cervical spine was performed in seven patients after a period of 12 months and showed that the bone destruction in DSA is very rapid and progressive. The lower biocompatibility of the cuprophan membranes of dialyzers is probably the factor most responsible for hyperproduction of
2-m and subsequently osteoarticular deposition of a new type of amyloidosis. 相似文献
45.
目的 :研究皖北地区经输血传播病毒 (TTV)在血透患者中的感染。方法 :选TTVORF1的保守序列作内外引物 ,采用微板核酸杂交 -ELISA方法检测血透患者 6 0例及对照组血清标本中的TTV DNA。结果 :对照组和血透患者间TTV的阳性率差异显著 (P <0 0 5 ) ;TTV阳性和阴性的血透患者 ,在透析次数和透析时间方面有统计学意义 (P<0 0 5 )。结论 :皖北地区一般人群和血透患者中存在TTV感染 ,后者是TTV感染的高危人群。TTV可能与HBV ,HCV ,或HGV有类似的传播途径 ,主要经血液途径传播。 相似文献
46.
目的: 分析影响维持性血液透析患者 (血透) 感染HCV 的因素。方法: 收集120 例血透患者的临床资料并进行统计学分析。结果: 血透患者HCV感染与血透时间、每周透析时间、输血、血制品史和量、肾移植史、院内感染史、ALT增高史显著相关。结论: 输血为血透患者感染HCV的主要途径, 但也存在医源性传播的可能 相似文献
47.
目的:探讨维持性血液透析对老年人心血管系统的影响;方法:对46例老年维持性血透与50例非老年维持性血透对患者心血管系统的影响进行了分析比较;结果:维持性血透引起血压、高血压、心律失常、心绞痛、心力衰竭等心血管并发症,老年组显著高于对照组(P〈0.01)。因心血管并发症致死者,老年组占60.0%;结论:维持性血液透析对老年人尤易引起心血管系统并发症,并为其主要死亡原因。故在透析中有效防治心血管并发症 相似文献
48.
Effect of metabolic acidosis on hyperlipidemia in uremia 总被引:2,自引:0,他引:2
Mak RH 《Pediatric nephrology (Berlin, Germany)》1999,13(9):891-893
Nine patients (aged 18±1 years) on maintenance hemodialysis with metabolic acidosis and hyperlipidemia were studied before
and after 2 weeks of oral sodium bicarbonate (NaHCO3) treatment to correct the acidosis. To control for the effect of additional sodium, they were also studied after 2 weeks
of an equivalent amount of oral sodium chloride (NaCl). Oral NaHCO3 treatment led to significant increases in venous pH, serum bicarbonate, and serum 1,25-dihydroxyvitamin D3 concentrations, but no significant change in total and ionized calcium, phosphate, sodium, potassium, creatinine, blood urea
nitrogen, and intact parathyroid hormone concentrations. Oral NaCl did not change any of the biochemical parameters. Before
treatment of acidosis, these uremic patients had high serum triglycerides, low serum high-density lipoprotein (HDL) cholesterol,
but normal total cholesterol compared with controls. Following 2 weeks of NaHCO3 treatment, there was a significant decrease in the serum concentrations of triglycerides (P<0.01). HDL and total cholesterol did not change. There were no changes in triglycerides, HDL or total cholesterol from baseline
values following 2 weeks of NaCl. Thus treatment of metabolic acidosis ameliorated hypertriglyceridemia but had no effect
on HDL and total cholesterol in patients with uremia on hemodialysis. The underlying mechanism may involve 1,25-dihydroxyvitamin
D3.
Received: 3 August 1998 / Revised: 30 November 1998 / Accepted: 2 December 1998 相似文献
49.
Dixit MP Cabansag MR Piscitelli J Greifer I Silverstein DM 《Pediatric nephrology (Berlin, Germany)》1999,13(2):139-142
Amyloidosis is a complication of long-term hemodialysis treatment. The major histological feature of hemodialysis-associated
amyloidosis (HAA) is the deposition of amyloid fibrils in the affected lesions, due, in part, to elevated serum β2-microglobulin (β2M) levels. In vitro studies reveal that serum immunoglobulin light and heavy chains co-deposit with β2M
in tissues affected by HAA. Only one study of HAA has been performed in young dialysis patients. We therefore assessed risk
factors for HAA in a group (n=30) of young (18.7±0.9 years) patients receiving chronic, uninterrupted hemodialysis using cellulose acetate membranes. All
patients initiated dialysis before reaching 18 years of age. The pre-dialysis serum β2M level was 49.7±3.9 mg/l (normal 0–2.4
mg/l). Since serum albumin was normal (4.3±0.1 mg/dl) and serum protein/albumin was elevated (1.7±0.0, normal 1.2–1.5), indicating
increased circulating protein, we assayed immunoglobulins in the same patients. The serum immunoglobulin levels (expressed
as a percentage of the total level of serum proteins) were elevated (21.3±0.9%, normal 11.1%–21.0%). The Kt/v was 1.37±0.03,
suggesting that the high levels of serum β2M and immunoglobulins were not due to inadequate dialysis in these patients. Patients
with residual renal function (Kr) did display significantly lower serum levels of β2M (33.2±2.3, P=0.03). Furthermore, improved clearance of β2M correlated with higher values of Kr (r=0.914). In contrast, serum levels of immunoglobulin (22.6±3.7, P=0.5) were unaffected by Kr. In addition, there was no correlation between older age at onset of dialysis and serum levels
of either β2M (r=0.107) or immunoglobulins (r=0.321). Finally, the length of time on dialysis had no effect on serum levels of either β2M (r=0.105) or immunoglobulins (r=0.092). Taken together, these results indicate that young hemodialysis patients may be at risk for HAA.
Received: 13 January 1998 / Revised: 1 June 1998 / Accepted: 2 June 1998 相似文献
50.
A bloodless technique of evaluating protein catabolic rate (PCR) and KT/V (K, clearance; T, dialysis time; V, urea distribution volume) in hemodialysis patients is presented based on serial measurement of urea in the dialysate effluent stream. PCR follows from equating urea generation and urea removal over a 7 day cycle, changes in body stores being comparatively negligible: PCR = 0.026 [U1 + U2 + U3]/BWdry + 0.17, where U1 is the amount of urea in mmol appearing in the dialysate for each session in the 7 day period. KT/V is obtained from the slope of the natural logarithm of spent dialysate urea concentration-time plot: KT/V = [- slope.T + 3.delta BW/BWdry]/[1 - 0.01786.T(hr], where delta BW = amount ultrafiltered in liters. The dialysate-based approach was validated and compared with conventional urea kinetic modeling (UKM) for 17 patients studied for three consecutive dialyses. The dialysate-based and UKM values of PCR agreed well when in vivo clearance values based on total dialysate collection were used for UKM. KT/V values agreed poorly on a session-by-session basis but were nearly equivalent when averaged for the three dialyses of the week. These findings lay the foundation for UKM automation with a urea sensor in the effluent dialysate stream. 相似文献