甲硝唑乳膏的制备及质量控制

目的:制备甲硝唑乳膏并建立其质量控制标准。方法:以甲硝唑为主药制备甲硝唑乳膏,采用紫外分光光度法测定甲硝唑乳膏中甲硝唑的含量。结果:甲硝唑的平均回收率为100.2％,RSD为1.7％。结论:该制剂处方及工艺具有生产可行性,其质量控制标准符合《中国药典》要求,含量测定方法简单、快速、准确。     

反相高效液相色谱法测定复方二氧化钛乳膏中水杨酸苄酯的浓度

目的:建立复方二氧化钛乳膏中水杨酸苄酯的含量测定方法.方法:采用反相高效液相色谱法(RP-HPLC).色谱柱Hypersil ODS C18(5 μm,4.6 mm×250 mm);流动相为甲醇-水(79∶21);紫外检测波长308 nm;流速1 mL*min-1.结果:水杨酸苄酯在5～30 mg·L-1的浓度范围内线性良好(r=0.9999),平均回收率为100.6%,RSD为1.17%(n=5);日内平均RSD为1.27%(n=5),日间平均RSD为1.57%(n=5).结论:该方法简便、快速、准确,可作为该制剂的质控方法.     

4%与1%吲哚美辛乳膏的镇痛抗炎作用比较

目的:观察4%与1%吲哚美辛乳膏的镇痛抗炎作用.方法:以1%吲哚美辛乳膏为对比,对几种炎症、疼痛模型考察4%吲哚美辛乳膏的治疗作用.结果:4%吲哚美辛乳膏对甲醛致小鼠足部疼痛、热板法致小鼠足部疼痛、大鼠尾部压痛均有明显镇痛效果,对卡拉胶致大鼠足肿胀和二甲致小鼠耳肿胀有明显抗炎效果.结论:4%吲哚美辛乳膏具有明显的镇痛抗炎药效,优于1%吲哚美辛乳膏.     

磺胺噻唑鱼肝油乳剂的制备及质量控制

目的:介绍磺胺噻唑鱼肝油乳剂制备方法及质量控制.方法:采用三波长分光光度法.结果:经过系列波长筛选,最后确定该制剂的测定组合波长为297,290,263 nm.结论:磺胺噻唑鱼肝油乳剂稳定、制备简便,质量控制方法准确.     

温通膏外敷联合中频电疗治疗冻结肩的疗效观察

目的:观察温通膏外敷联合中频电疗对冻结肩的临床疗效。方法:选取90例冻结肩病例,随机分为温通膏组、中频组,联合组。温通膏组使用温通膏外敷患者患处,中频组使用中频电疗,联合组则同时给予温通膏外敷及中频电疗治疗,三组均连续治疗10天。观察患者治疗前后的Constant-Murley肩关节评分中的疼痛评分、活动度评分,并于3个月后随访患者,记录复发情况。结果:治疗后,三组患者的肩关节Constant-Murley疼痛评分、活动度评分均高于治疗前(P<0.05);联合组患者的肩关节Constant-Murley疼痛评分、活动度评分明显优于温通膏组及中频组(P<0.05);治疗3个月后联合组的复发率(6.67%)明显低于其它两组。结论:温通膏联合中频电疗可以有效缓解冻结肩患者的疼痛,改善活动度,临床效果较单独使用温通膏外敷或中频电疗更优。     

Evaluation of clinical and financial outcomes of a new no‐sting barrier film and barrier cream in a large UK primary care organisation

The study involves 95 subjects within a UK Primary Care Organisation and was undertaken in two arms. The objective was to determine the clinical outcomes and clinical acceptability of a newly available range of no‐sting barrier film and no‐sting barrier cream products offering significant financial benefits. The importance of undertaking this study is underpinned by evidence in the literature relating to the use of no‐sting barrier preparations within clinical practice. The first part of the study (arm 1) involved extensive evaluation of either the film or cream barrier in 36 patients and was compared to existing standardised barrier protection care within the organisation. The results indicated that the new product range met all the criteria for formulary inclusion and following this the barrier range was further evaluated in arm 2, 33 patients with barrier cream and 26 patients with barrier film. The entire study was conducted over a 3‐month period with patient treatment lasting a minimum of 2 days to a maximum 4‐week period adhering to the agreed evaluation protocol as approved by clinical governance. In arm 1 (n = 36), the clinical expectation of the product was met in 32 cases relating to ease of use, conformability, no‐sting, quick drying, ease of absorption, compatibility with devices, frequency of application, prevention and management including visual skin improvement resulting in a recommendation for formulary listing in 31 of 36 cases. In arm 2 (n = 59), barrier film and barrier cream performance was consistently rated same as, better than or much better than the existing barrier used. A formulary listing recommendation was made in 51 of 59 cases.     

自拟疏肝清肺饮治疗成年女性轻中度痤疮的临床观察

目的 探讨自拟方疏肝清肺饮治疗成年女性轻、中度痤疮的临床效果.方法 选取首都医科大学良乡教学医院皮肤科门诊年龄25～ 45岁的女性轻、中度痤疮患者86例,按患者单双日就诊次序随机分为2组单日就诊为对照组,双日就诊为观察组.对照组40例口服红霉素肠溶胶囊0.5g/次,2次/d;同时外用0.025％的维A酸乳膏,1次/晚.观察组46例口服自拟疏肝清肺饮,每日1剂,分2次服用;同时也外用0.025％的维A酸乳膏,1次/晚.疗程6周,每周随访1次.疗程结束后分别比较2组患者的治疗效果.结果 对照组患者有效率为75.0％ （30/40）;观察组患者有效率为87.0％ （40/46）,2组的有效率比较差异无统计学意义（P＞0.05）.结论 自拟方疏肝清肺饮配合外用维A酸乳膏治疗成年女性轻、中度痤疮与红霉素肠溶胶囊加维A酸乳膏具有相近的疗效,为临床治疗这类痤疮患者提供了新的选择.     

芪人抗皱霜祛皱作用的临床研究

目的：探讨芪人抗皱霜祛除皮肤皱纹的临床疗效。方法：将90例符合纳入标准的受试对象随机分为试验组和对照组。试验组使用芪人抗皱霜,对照组使用普通祛皱霜,分别于皮肤皱纹测试部位外涂,每日早晚各涂一次,使用周期为40天。试验前后均拍照进行皮肤皱纹等级及积分评价,同时用硅橡胶复制皮肤皱纹模型,应用图象分析软件对其进行分析处理。结果：临床观察结果表明,芪人抗皱霜能够降低受试对象的皱纹积分,降低皮肤皱纹深度及皮肤皱纹粗糙度,并优于对照组（P〈0.01）。结论：芪人抗皱霜有较好的祛皱美容作用,未发现任何不良反应,不失为一种安全有效的美容产品。