试尖对根管充填质量影响的研究

目的：了解试尖对侧向加压法根管充填质量的影响因素。方法：随机提取我院1998年10月至2004年12月所完成的根管充填病例的X线片1000例，按试尖与未试尖，分别对前牙、前磨牙和磨牙根管充填质量进行分析。结果：在482例未试尖根管充填病例中，前牙、前磨牙和磨牙的适充比例分别为46％、37％和23％，欠充为20％、29％和47％。超充为34％、33％和29％：在518例试尖病例中，前牙、前磨牙和磨牙的适充比例分别为68％、62％和51％，欠充为6％、12％和13％，超充为25％、24％和36％。结论：在侧向加压法根管充填中，试尖可明显改善充填质量。     

THE EFFECT OF ACUPUNCTURE ON PREVENTION AND TREATMENT OF ISCHEMIC ARRHYTHMIA AND THE RELATION BETWEEN EFFECT OF ACUPUNCTURE AND CHOLINERGIC MUSCARINE-LIKE RECEPTORS

For investigating the effect of acupuncture on ischemic arrhythmia and its mech-anism, adult albino rats with ligated anterior descending branch of coronary artery as experimentalmodel were treated with or without acupuncture, and others with imitative operation but without bothcoronary artery ligation and acupuncture treatment were used as control. It was found in acupuncturegroup that the fibrillation-liability of ischemic myocardium was efficiently decreased, the affinity ofAch-M receptors on membranes of ischemic myocardium was markedly increased, and the tolerance ofischemic myocardium to atropine was elevated in the experiment of atropine inducing fibrillation.These results indicate that acupuncture may play a therapeutic role on ischemic arrhythmia throughactivating the activity of muscarine-like receptors of cholinergic nervous system.     

基于薄板样条和形状内容的医学图像非刚性配准方法研究

目的 针对医学图像非刚性点配准的现状,给出一种基于点特征的非刚性配准方法.方法 利用一种新的相似度测量方法--形状内容来解决两幅图像中点的对应关系,并利用点对应关系来估计非刚性映射函数.结果 利用薄板样条实现了医学图像的快速准确非刚性配准.结论 实验结果表明,上述方法获得了很好的配准效果.     

虚拟现实互动技术在交叉韧带等长重建计算机辅助设计中的应用

目的 利用虚拟现实技术还原膝关节骨性结构在屈伸运动过程中的三维空间形态，为观测膝关节面交叉韧带附丽区的相对位置变化和进一步研究前、后交叉韧带等长重建最佳等长点提供计算机辅助设计新方法。方法 采用实验与计算机仿真相结合的方法，对新鲜人体膝关节标本进行屈伸运动实验，并通过激光三维扫描方法记录、计算膝关节的空间活动指标，然后重建膝关节计算机三维模型。通过实验中的空间活动指标控制此模型虚拟运动，再现膝关节各屈伸角度下股骨、胫骨和腓骨的空间位置。结果 计算机还原出各运动角度下膝关节骨性结构（股骨、胫骨及关节面）的空间形态，利用软件Geomagic的几何计算功能可分别测量模型中各个运动状态交叉韧带附丽区两点间的三维空间距离。讨论本研究方法可以真实地记录和再现膝关节三维运动过程，从空间结构上更精确、合理地寻找重建等长点，对膝关节交叉韧带手术重建有重要临床意义。     

针刺加中药治疗功能性消化不良120例疗效观察

目的　观察针刺加中药治疗功能性消化不良的临床疗效。方法　 1 80例功能性消化不良患者随机分为 2组。治疗组 1 2 0例采用针刺加中药治疗 ,对照组 6 0例单用西药对症治疗 ,2组均治疗 2周后观察疗效。结果　治疗组总有效率为 95 .8% ,对照组为 83.4 % ,2组比较有显著性差异 (P <0 .0 1 )。结论　针刺加中药治疗功能性消化不良具有显著疗效     

中西药物保留灌肠合并针灸治疗溃疡性结肠炎的临床研究

目的 观察中西药物保留灌肠合并针灸治疗溃疡性结肠炎(UC)的疗效.方法 对确诊的63例UC患者随机分为两组,治疗组(32例)用中西药物150 mL睡前保留灌肠合并针灸治疗,每日1次,疗程4周;对照组(31例)用强的松龙100 mg、庆大霉素16万u加生理盐水150 mL睡前保留灌肠,每日1次,疗程4周.然后比较疗效.结果 治疗组疗效明显高于对照组,总有效率分别为96.9%和77.4%,1年复发率分别为9.37%和25.8% (P<0.05).两组差异有统计学意义.结论 中西药物保留灌肠合并针灸治疗UC疗效显著,复发率低,有临床应用价值.     

RF refocused echoes of J-coupled spin systems: effects on RARE-based spectroscopic imaging.

A numerical simulation tool was developed to calculate the echo amplitudes of J-coupled resonances within a series of radiofrequency (RF) refocused echoes. The signal modulation due to J-coupling in rapid acquisition with relaxation enhancement (RARE) is suppressed only when the inverse of the pulse interval (tau) is large compared to both the chemical shift (CS) difference (Deltadelta) of the coupled spins and the coupling constant. In contrast, the echo amplitudes in ultrafast low-flip-angle RARE (U-FLARE) oscillate around a quasi-steady-state value that is greater than zero (neglecting relaxation and diffusion) even when Deltadelta > 1/tau. The flip-angle distribution over the measured slice caused by the use of Gaussian-shape slice-selective refocusing pulses further reduces the echo oscillations. When the pulse interval falls short of the fast pulse rate regime, spectroscopic U-FLARE provides an improved spatial impulse response in the phase-encoding (PE) direction compared to spectroscopic RARE.     

日本针灸按摩业的教育现状

在日本,针灸、按摩不属于医疗行为,而属于医疗近似行为,明治以来与汉方医学一起受到很大冲击.本文对日本针灸按摩业的沿革发展、学会组织及教育现状进行了归纳.     

7种蛇类药材的等电点鉴别研究

用改进的蛋白质等电点法对7种蛇类药材进行了鉴别研究。结果表明不同种类的蛇,等电点有所不同。重现性好(CV<0.5),其等电点均值的差别(P<0.01)有非常显著的意义,可以作为去皮或粉末状蛇类药材鉴别的依据之一。     

Screening of H-ras Gene Point Mutations in 50 Cases of Bladder Carcinoma

Background Mutation converts the H-ras gene into an activated oncogene in about 10% of human bladder cancers. Codons 12 and 61 are the major "hot spots" for activation. A simple and accurate method to detect point mutations in these codons may be clinically useful for early diagnosis of bladder cancer.
Methods Bladder cancer samples from 50 patients, plus 10 samples of normal bladder mucosa, were analyzed for possible point mutation of the H-ras gene at either codon 12 or codon 61. The H-ras gene DNA segments that include these 2 codons were amplified by PCR methods, then the possible presence of a point mutation was evaluated at each codon by susceptibility of the respective DNA segments to digestion with the restriction enzyme and by dot blot hybridization assay. A bladder cancer patient who had an H-ras gene mutation was examined to see whether the mutation was also detectable in the cells released in the urine.
Results Definite or possible point mutations were found in 6 (1 2%) out of 50 bladder cancer patients, while no mutation was detected in normal mucosa. A point mutation could also be detected in cells isolated from the patient's urine sample.
Conclusion The prevalence of point mutations at codon 1 2 or codon 61 of the H-ras gene found in this study was similar to that previously estimated for human bladder cancer by DNA transfection assay. The method we have used for detecting point mutations of the H-ras gene provides a simple and highly accurate way to detect mutated cancer cells even in the urine. It may be clinically usable for early diagnosis of bladder cancer.