Bioactive compounds in berries relevant to human health

Berries contain powerful antioxidants, potential allergens, and other bioactive compounds. Genetic and environmental factors affect production and storage of such compounds. For this reason breeding and biotechnological approaches are currently used to control or to increase the content of specific health-related compounds in fruits. This work reviews the main bioactive compounds determining the nutritional quality of berries, the major factors affecting their content and activity, and the genetic options currently available to achieve new genotypes able to provide, under controlled cultivation conditions, berries with the proper balance of bioactive compounds for improving consumer health.     

The optimal times and levels of impulsive acquisition of automation

A dynamic optimization model is formulated to derive the optimal mix of output achieved manually and from automatic equipment. Therefore, the composition of the productive capacity is obtained for a firm over time. The actual times and levels at which automation should be acquired and the levels of change in manual output are determined over the planning horizon. Optimal policies are derived in order to minimize costs associated with deviation from the goal levels of total output, acquiring automation, changing the level of manual output, operating automation and operating manual equipment over time. Ordinary and impulsive optimal control theory techniques are applied to obtain solutions.     

Patterns of cerebellar foliation in recombinant inbred mice

Morphometric analysis of cerebellar foliation patterns at the midsagittal plane was done in the inbred strains BALB/cByJ, C57BL/6ByJ and their 7 recombinant inbred strains in order to assess possible major gene influences. The cerebellum was dissected away from the brainstem and weighed prior to histology so that measures of the depth of fissures and sulci could be related to overall size of the brain and cerebellum. Results for 177 mice revealed that many brains had extra sulci present within the central lobe, the culmen, the declive and the uvula, and that patterns within a genetically uniform inbred strain were highly variable. The measure of sulcus depth was continuous, showing no evidence of a normal versus abnormal dichotomy. Furthermore, the frequency and depth of extra sulci were greater in mice with larger cerebella. Strain differences in size of the whole brain and cerebellum clearly resulted from several genetic loci. This was also true of the extra sulci, except for the declival sulcus which revealed a single gene influence. The gene symbol 'declival sulcus of cerebellum' (dsc) is proposed.     

辅酶A发酵概述

综述了辅酶 A 的生物合成及其反馈抑制、发酵及其控制方面的报道,结合工作体会提出了通过菌种改良和代谢调控提高辅酶 A 生产水平的一些途径。     

XE-2100全自动血细胞分析仪在慢性肾衰血液透析中的应用研究

目的 探讨利用XE-2100全自动血细胞分析仪检测血液透析患者动脉血红细胞压积来确定血容量的改变。方法 对60例慢性肾衰维持性血液透析的患者,在透析过程中分5次检测透析管路动脉端血液红细胞压积,并根据红细胞压积变化计算血容量(BV)下降比率,同时监测血压变化,以此确定合适的干体重和透析速度。结果 在超滤4小时后有14例患者红细胞压积升高太多,血容量下降超过允许范围(>15％),以至于收缩压下降超过30mmHg,部分患者出现低血压症状。46例患者红细胞压积上升合适,血容量下降正常(<15％),收缩压下降小于30mmHg,无低血压症状出现。结论 在一定的时间内多次检测红细胞压积来计算透析血容量,使血容量下降率控制在15％以内,就可以减少透析性低血压的发生。