全文获取类型
收费全文 | 7626篇 |
免费 | 884篇 |
国内免费 | 216篇 |
专业分类
耳鼻咽喉 | 1683篇 |
儿科学 | 198篇 |
妇产科学 | 42篇 |
基础医学 | 1135篇 |
口腔科学 | 214篇 |
临床医学 | 775篇 |
内科学 | 1000篇 |
皮肤病学 | 82篇 |
神经病学 | 71篇 |
特种医学 | 153篇 |
外国民族医学 | 1篇 |
外科学 | 496篇 |
综合类 | 1183篇 |
预防医学 | 239篇 |
眼科学 | 186篇 |
药学 | 842篇 |
8篇 | |
中国医学 | 247篇 |
肿瘤学 | 171篇 |
出版年
2024年 | 12篇 |
2023年 | 123篇 |
2022年 | 190篇 |
2021年 | 324篇 |
2020年 | 338篇 |
2019年 | 352篇 |
2018年 | 288篇 |
2017年 | 310篇 |
2016年 | 374篇 |
2015年 | 298篇 |
2014年 | 563篇 |
2013年 | 630篇 |
2012年 | 512篇 |
2011年 | 487篇 |
2010年 | 351篇 |
2009年 | 353篇 |
2008年 | 300篇 |
2007年 | 344篇 |
2006年 | 326篇 |
2005年 | 281篇 |
2004年 | 258篇 |
2003年 | 202篇 |
2002年 | 210篇 |
2001年 | 170篇 |
2000年 | 135篇 |
1999年 | 129篇 |
1998年 | 129篇 |
1997年 | 109篇 |
1996年 | 76篇 |
1995年 | 80篇 |
1994年 | 62篇 |
1993年 | 74篇 |
1992年 | 54篇 |
1991年 | 30篇 |
1990年 | 29篇 |
1989年 | 32篇 |
1988年 | 34篇 |
1987年 | 17篇 |
1986年 | 16篇 |
1985年 | 21篇 |
1984年 | 23篇 |
1983年 | 18篇 |
1982年 | 15篇 |
1981年 | 9篇 |
1980年 | 11篇 |
1979年 | 9篇 |
1978年 | 8篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1972年 | 2篇 |
排序方式: 共有8726条查询结果,搜索用时 15 毫秒
71.
72.
鼻腔恶性黑色素瘤10例临床病理分析 总被引:2,自引:1,他引:2
汪娟 《临床与实验病理学杂志》2008,24(2):222-224
目的 探讨鼻腔恶性黑色素瘤的临床病理特征,并对其诊断和鉴别诊断进行讨论.方法 结合组织形态学结构和免疫组化,对10例鼻腔恶性黑色素瘤进行临床病理分析.结果 10例鼻腔恶性黑色素瘤中男性3例,女性7例,年龄52~83岁,平均年龄59.8岁.肿瘤由上皮样,梭形及未分化小细胞等多种类型的细胞组成.免疫组化标记瘤细胞均表达HMB-45、S-100蛋白、vimentin.结论 鼻腔黏膜恶性黑色素瘤易误诊为其它鼻腔原发性肿瘤,导致临床处理不当,延误治疗,与皮肤恶性黑色素瘤相比,鼻腔黏膜恶性黑色素瘤更具有侵袭性、预后差等特点. 相似文献
73.
74.
75.
Krug N Hohlfeld JM Geldmacher H Larbig M Heermann R Lavallee N Nguyen DT Petzold U Hermann R 《Allergy》2005,60(3):354-359
BACKGROUND: Loteprednol etabonate (LE) is a novel soft steroid that was designed to improve the benefit/risk ratio of topical corticosteroid therapy. This study assesses the clinical efficacy and safety of three different doses of LE nasal spray in seasonal allergic rhinitis (SAR). METHODS: In this single-center, double-blind, placebo-controlled, parallel-group trial 165 subjects with SAR to grass pollen received daily single doses of either 100, 200, 400 microg LE nasal spray, or placebo for 14 days. The patients underwent three 4-h allergen challenges with grass pollen in an environmental exposure unit at a screening visit (baseline) and on days 7 and 14 of treatment. Standardized nasal symptom scores were obtained every 20 min. Nasal flow, nasal secretions, and FEV(1) were measured every hour during allergen challenges. RESULTS: After 14 days of treatment, patients who received 400 microg LE had significantly lower total nasal symptom scores compared with those receiving placebo (P = 0.007). LE400 reduced rhinorrhea, nasal congestion, nasal itching, the amount of nasal secretions, and improved nasal flow as compared with placebo (P < 0.05). LE100 and LE200 were not significantly different from placebo. All treatments were well tolerated. CONCLUSIONS: Loteprednol 400 microg once daily is superior to placebo and the only effective dose tested in improving nasal symptoms and objective parameters in patients with SAR. 相似文献
76.
We studied the effect and onset of action of fluticasone propionate aqueous nasal spray (FPANS) on mediator release and eosinophil accumulation in nasal secretions and on nasal symptoms of patients with seasonal allergic rhinitis after nasal allergen challenge (NAC). At the end of the pollen season, 28 patients were randomized in a double-blind and crossover design to receive 7 days' treatment with FPANS (200 μg, once daily) and matching placebo. NACs were performed before and at 6 h and 1. 2. 3. and 7 days during treatment with FPANS or placebo. Nasal secretions were collected for a quantitative determination of mediators and eosinophil count before and 5 min after each challenge. Nasal symptoms were assessed by scales grading the severity of symptoms at the same time. Results showed that for mediator concentrations there was a significant decrease of leukotriene C4 (P<0.001) at 7 days after the first administration of FPANS as compared to placebo. Two days after FPANS. both eosinophil counts and eosinophil cationic protein (ECP) concentrations were lower than those of placebo (eosinophils; f=0.032; ECP; F=0.038). The onset became even more important at day 7 (eosinophils; P=0.001; ECP; P=0.009) during the FPANS treatment period. For the subjective nasal symptoms, a significant reduction of symptom scores for nasal obstruction occurred also at day 3 (F=0.017) and for sneezing at day 7 (f=0.003). There was not yet any significant improvement of the objective nasal airway resistance after the different NACs during the study period. In conclusion, this study demonstrated that topical fluticasone propionate is effective in the treatment of mucosal inflammation induced by NAC. For optimal control of nasal symptoms induced by repeated maximal allergen challenges, a treatment period of more than 1 week is required. 相似文献
77.
Reiko Yoshida Yoshimitsu Fukushima Hirofumi Ohashi Masako Asoh Yukio Fukuyama 《Journal of human genetics》1993,38(4):437-444
Summary Two patients with the Costello syndrome are presented. One was a 7-year-old girl with a history of infantile hypotonia and feeding difficulties. The other was a 3 5/12-year-old boy with a history of neonatal sepsis and respiratory problems. Both had relative macrocephaly at birth, curly hair, large ear lobes, epicanthic folds, a low nasal bridge, thick lips, a short and wide nose, a short neck, a barrel chest, redundant skin, tight Achilles tendons, and pes equinovarus. Nasal papillomata, as described in Costello's two patients, were absent in both patients. Borochowitzet al. (1992) described five patients with what we interpreted as the Costello syndrome but without nasal papillomata. In view of these findings, nasal papillomata are not likely to be essential in the diagnosis of the Costello syndrome. 相似文献
78.
Kazuya Takeda Shuhei Sakakibara Kazuo Yamashita Daisuke Motooka Shota Nakamura Marwa Ali El Hussien Jun Katayama Yohei Maeda Masanobu Nakata Shigeyuki Hamada Daron M. Standley Masaki Hayama Takashi Shikina Hidenori Inohara Hitoshi Kikutani 《The Journal of allergy and clinical immunology》2019,143(3):1163-1175.e15
79.
Ruocco Fattori Romanelli Martelloni Casani Samolewska & Rezzonico 《Clinical and experimental allergy》1998,28(7):881-888
80.
Wellinghausen N Sing A Kern WV Perner S Marre R Rentschler J 《International journal of medical microbiology : IJMM》2002,292(1):59-63
A 77-year-old farmer developed cough with sputum production, fever, bloody nasal discharge and a mass in his right maxillary sinus leading to necrotic ulceration of the sinus. Corynebacterium ulcerans, carrying the beta-phage for the diphtheria toxin and secreting the toxin, was detected microscopically and by culture from the sinusoidal and ulcer discharge. Despite immediate antimicrobial chemotherapy the patient died of pulmonary failure associated with the production of large amounts of very viscous sputum. Identification of the causative agent, pathophysiological aspects and risk factors of this unusal infection are discussed. 相似文献