Endotypes of chronic rhinosinusitis based on inflammatory and remodeling factors

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Proteomic analysis of nasal mucus samples of healthy patients and patients with chronic rhinosinusitis

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Defective STING expression potentiates IL-13 signaling in epithelial cells in eosinophilic chronic rhinosinusitis with nasal polyps

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GM-CSF instigates a dendritic cell–T-cell inflammatory circuit that drives chronic asthma development

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Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity

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The triglyceride to HDL-cholesterol ratio and chronic graft failure in renal transplantation

BackgroundTransplant vasculopathy (TV) is a major contributing factor to chronic graft failure in renal transplant recipients (RTR). TV lesions resemble atherosclerosis in several ways, and it is plausible to believe that some risk factors influence both atherosclerotic plaque formation and formation of TV.ObjectiveThe objective of this prospective longitudinal study was to determine if dyslipidemia reflected by the triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio is prospectively associated with death censored chronic graft failure in RTR.Method454 prospectively included RTR with a functioning graft for at least one year, were followed for a median of 7 years. RTR were matched based on propensity scores to avoid potential confounding and subsequently the association of the TG/HDL-C ratio with the endpoint chronic graft failure, defined as return to dialysis or re-transplantation, was investigated.ResultsLinear regression analysis showed that concentration of insulin, male gender, BMI and number of antihypertensives predict the TG/HDL-C ratio. Cox regression showed that the TG/HDL-C ratio is associated with chronic graft failure (HR = 1.43, 95%CI = 1.12–1.84, p = 0.005) in competing risk analysis for mortality. Interaction testing indicated that the relationship of the TG/HDL-C ratio with graft failure is stronger in subjects with a higher insulin concentration.ConclusionOur results demonstrate that the TG/HDL-C ratio has the potential to act as a predictive clinical biomarker. Furthermore, there is a need for closer attention to lipid management in RTR in clinical practice with a focus on triglyceride metabolism.     

Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis

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HCMV-controlling NKG2C+ NK cells originate from novel circulating inflammatory precursors

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The sputum microbiome,airway inflammation,and mortality in chronic obstructive pulmonary disease

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Multidimensional endotyping using nasal proteomics predicts molecular phenotypes in the asthmatic airways

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