医用三氧联合玻璃酸钠关节腔注射治疗膝骨性关节炎的临床效果

目的观察医用三氧联合玻璃酸钠关节腔注射治疗膝骨性关节炎的临床疗效。方法膝骨性关节炎患者100例,在膝关节腔内注射玻璃酸钠20mg后再注射30μg／ml的医用三氧10ml,每周1次,5周为1个疗程。结果治疗后各时点VAS评分较治疗前均下降（P〈0.05）。治疗后6个月时临床疗效结果为临床控制40例（40％）,良效30例（30％）,微效18例（18％）,无效12例（12％）,总有效率为88％（88／100例）。结论医用三氧联合玻璃酸钠关节腔注射可有效治疗膝关节骨性关节炎,疗效持续时间长,无明显不良反应。     

臭氧联合胶原酶注射治疗腰椎间盘突出症668例疗效分析

目的通过对小C臂导向下臭氧与胶原酶联合注射治疗腰椎间盘突出症患者的疗效观察与分析,总结临床经验,提高疗效。方法对在我院行小C臂导向下臭氧与胶原酶联合注射治疗1年以上的870例患者进行电话随访,共随访到668例,根据治疗后的时间分为三组:其中Ⅰ组(治疗后12～24个月)238例、Ⅱ组(治疗后25～48个月)230例、Ⅲ组(治疗后49～72个月)200例,采用改良的Macnab腰腿痛疗效评定标准评估疗效。结果Ⅰ组优良率为91.18%;Ⅱ组优良率为90.87%;Ⅲ组优良率为89.00%,总体优良率为90.35%。三组优良率比较差异无统计学意义(P>0.05)。所有患者均无重大不良事件和严重并发症发生。结论小C臂导向下臭氧与胶原酶联合注射治疗腰椎间盘突出症新技术安全,远期疗效满意。术前明确诊断,严格把握适应证;术中准确定位,熟练穿刺技术,严格操作规程,实施个性化方案和术后规范康复训练是提高远期疗效、减少并发症的关键所在。     

4530例医用三氧自血疗法治疗肿瘤患者的护理

目的：总结肿瘤患者医用三氧基本自血疗法的护理方法和技巧。方法：对2008年9月-2011年3月4530例肿瘤患者行医用三氧基本自血治疗的护理工作进行回顾性分析。将加强细节管理、严格掌握禁忌证和适应证、关注注意事项、细致的心理护理、密切观察病情变化作为护理的重点。结果：行医用三氧基本自血治疗的4530例肿瘤患者中只有13例患者出现虚脱、头晕、血压改变和静脉穿刺疼痛等不良反应。结论：加强细节管理,合理的操作流程,严格掌握禁忌证、适应症和注意事项,加强心理护理等一系列护理措施,能确保医用三氧自血疗法的安全应用。     

射频热凝联合三氧注射治疗带状疱疹后神经痛

目的观察射频热凝联合皮内臭氧注射治疗带状疱疹后神经痛的疗效。方法50侧带状疤疹后神经痛患者,随机分成2组,单纯药物治疗组后（A组,25例）,射频热凝联合臭氧注射组（B组,25例）,采用视觉模拟评分（VAS）,分别对治疗前、后VAS评分进行统计分析。结果治疗后VAS比较,B组VAS评分明显低于A组（P〈0．05）,B组总有效率100％明显高于A组88％（22／25例）。结论射频热凝联合皮下臭氧注射是治疗带状疱疹后神经痛的有效方法。     

Prediction of ozone-induced lung function responses in humans

The main purpose of this study was to evaluate the ability of a human exposure-response model, which describes ozone-induced changes in forced expiratory volume in 1 second (FEV₁) across a wide range of dynamic exposure conditions, to predict responses in independent data. We first conducted an n-fold cross-validation of the model using samples of the original EPA data from which the model was developed. We then identified seven more recently published studies with controlled exposures to a wide range of ozone exposure patterns relevant to the current ambient ozone health standard and used the model to calculate the mean predicted responses for the exposure conditions of the individual studies that we compared to the mean observed responses reported in these studies. The n-fold cross-validation indicated good internal agreement between mean predicted and mean observed responses in the original data used to develop the model. The model accurately captured the patterns of response in each of the seven independent studies with a tendency to overpredict the observed responses by about 1 percentage point of FEV₁ decrement on average. We conclude that the model is currently capable of predicting human FEV₁ responses across a wide range of dynamic exposure conditions and anticipate further improvements in predictions with the addition of low-concentration exposure data.     

Modelling of individual subject ozone exposure response kinetics

Context: A better understanding of individual subject ozone (O₃) exposure response kinetics will provide insight into how to improve models used in the risk assessment of ambient ozone exposure.

Objective: To develop a simple two compartment exposure–response model that describes individual subject decrements in forced expiratory volume in one second (FEV₁) induced by the acute inhalation of O₃ lasting up to 8 h.

Methods: FEV₁ measurements of 220 subjects who participated in 14 previously completed studies were fit to the model using both particle swarm and nonlinear least squares optimization techniques to identify three subject-specific coefficients producing minimum “global” and local errors, respectively. Observed and predicted decrements in FEV₁ of the 220 subjects were used for validation of the model. Further validation was provided by comparing the observed O₃-induced FEV₁ decrements in an additional eight studies with predicted values obtained using model coefficients estimated from the 220 subjects used in cross validation.

Results: Overall the individual subject measured and modeled FEV₁ decrements were highly correlated (mean R² of 0.69 ± 0.24). In addition, it was shown that a matrix of individual subject model coefficients can be used to predict the mean and variance of group decrements in FEV₁.

Conclusion: This modeling approach provides insight into individual subject O₃ exposure response kinetics and provides a potential starting point for improving the risk assessment of environmental O₃ exposure.     

Anticlastogenic effect of diosgenin on 7,12-dimethylbenz(a)anthracene treated experimental animals

The maintenance of stable test atmospheres in small-volume inhalation systems such as a nose-only exposure manifold requires rapid and appropriate responses to fluctuations in a number of parameters. For example, changes in flows or voltages can affect test compound generation efficiency and gas dilution ratios, resulting in excursions of the test concentration outside an acceptable range. A feedback control loop was designed that makes use of mass flow controllers in maintaining the target concentration of a test compound. The system was tested by generating ozone in a nose-only exposure manifold. An ozone analyzer provided updated concentration values every 30 s, which were compared to the user-defined target concentration recorded in the interface readout box. Values of gain, integral, and lead determining an appropriate response of the controller to concentration fluctuations were implemented based on proportional-integral-derivative control algorithms. Using this approach, the flow of ozone mixed with dilution air into the system was adjusted as required without user intervention, minimizing concentration overshoots upon system startup, maintaining an ozone concentration within a range 5% of the target concentration, and responding rapidly and efficiently to line disturbances.     

臭氧盘内配合曲安奈德颈深筋膜间隙注射治疗神经根型颈椎病

目的探讨利用臭氧盘内注射配合曲安奈德颈深筋膜间隙注射治疗神经根型颈椎病的临床效果。方法将收治的60例神经根型颈椎病患者随机分为二组,比较MacNab评价和VAS评分差异。结果通过改良的MacNab疗效评价标准J和VAS评分,联合组在术后7天和3个月治疗效果明显优于臭氧组。结论臭氧盘内注射配合曲安奈德颈深筋膜间隙注射治疗神经根型颈椎病疗效优于单一臭氧治疗,值得临床推广应用。     

微创联合针刀松解术治疗椎间盘源性下腰痛疗效分析

目的 探讨微创联合针刀松解术治疗椎间盘源性下腰痛的疗效.方法 回顾性分析2009年10月至201 1年10月因下腰痛采用经皮臭氧腰椎间盘髓核化学溶解术32例患者(对照组)和该术结合针刀松解术治疗30例患者(观察组)的临床资料.对照组患者仅采用经皮腰椎间盘髓核化学溶解术治疗,观察组在对照组治疗的基础上,透视下对责任椎间盘节段软组织粗条索状改变及不规则结节处行针刀松解术.术后1周、6个月根据视觉模拟评分(VAS)、改良Macnab法进行疗效评定.结果 2组患者均完成随访.2组患者治疗后1周、6个月VAS均明显低于治疗前[对照组:(2.4±1.2)、(2.4±1.6)分比(5.4±1.2)分;观察组:(2.0±1.1)、(1.6±1.2)分比(5.3±1.3)分],差异均有统计学意义(均P＜0.01);术后1周观察组与对照组间差异无统计学意义(P＞0.05),术后6个月观察组明显低于对照组,差异有统计学意义(P＜0.05).对照组治疗后6个月优良率为65.6％ (21/32),观察组优良率为76.7％(23/30),组间优良率比较,差异有统计学意义(P＜0.05).结论 经皮微创治疗腰椎间盘源性下腰痛安全、可行,结合针刀松解术疗效显著.     

臭氧治疗对急性脑梗死患者脑血流的影响

目的探讨臭氧治疗对急性脑梗死患者脑血流的影响。方法选择急性脑梗死患者80例,随机分为对照组和治疗组各40例。两组均进行基础用药治疗,治疗组在此基础上加用臭氧治疗。于患者入院时及治疗2周后应用经颅多普勒超声仪（TCD）检测其大脑中动脉（MCA）、基底动脉（BA）、椎动脉（VA）平均血流速度（Vm）。结果治疗组治疗后MCA、BA、VA平均血流速度较对照组有明显改善,两组比较,差异均有高度统计学意义（P〈0．01）。结论臭氧治疗对急性脑梗死患者的脑血流有明显改善作用。