A Case Report of Inflammatory Pseudosarcoma of the Urinary Bladder

A case of inflammatory pseudosarcoma of the urinary bladder in a 35 year-old Japanese male is presented. This benign lesion can easily be mistaken for spindle cell sarcoma since it consists of rhabdomyoblast like elongated strap cells showing infiltrative growth, and whether it is benign or malignant is difficult to determine by microscopic examination. In this case, spindle cell proliferation extended among bundles of the superficial muscle layer. However, no abnormal mitoses, severe nuclear atypia or cellular pleomorphism could be seen, thus indicating inflammatory pseudosarcoma. Although the lesion was not completely resected, no recurrent disease has been clinically observed for two years following transurethral resection. Urologists and surgical pathologists must be able to detect this lesion in order to avoid unnecessary surgical procedures. Acta Pathol Jpn 42: 760 765,1992.     

Effect of isoelectric point on biodistribution and inflammation imaging with indium-111-labelled IgG

Electrostatic effects play an important role in protein interactions and may alter the biodistribution of antibodies. To study the effect of molecular charge on the biodistribution and infection imaging properties of human polyclonal immunoglobulin G (IgG), its iso electric point was varied by changing the level of diethylene triamine penta-acetic acid (DTPA) substitution: 0.8, 0.9, 3.7, 5.1 and 5.9 DTPA/IgG. Biodistributions of the different IgG preparations were determined at 10 min, 1, 6, 24, and 48 h post injection in normal rats, and infection imaging properties were determined in rats withEscherichia coli thigh infections. The biodistribution was significantly affected by pl. The immunoglobulin preparations with 0.9 and 3.7 DTPA/IgG showed faster clearance from the circulation and generally lower accumulation in most organs. The images had a target-to-background ratio of approximately 1.3–2.3:1. These results suggest that even though targeting is not affected by the level of DTPA substitutions, preparations with 0.9 and 3.7 DTPA/IgG may be superior imaging agents because of reduced accumulation by background organs.     

P53、C-erbB-2基因蛋白和EGFR在泌尿系移行细胞癌中的表达及相互关系

应用免疫组化技术研究65例泌尿系移行细胞癌（包括47例膀胱癌和18例肾盂癌）组织中P53、C－erbB－2基因蛋白和表皮生长因子受体（EGFR）的表达及相互关系。结果显示P53在膀胱癌中阳性率为57．5％（27／47），在肾益癌中为50．0％（9／18）；C－erbB－2基因蛋白在膀胱癌和肾盂癌中的表达率分别为40．4％和38．9％；EGFR的表达率分别为42.6％和44．4％。P53、C－erbB－2基因蛋白和EGFR表达均与膀胱癌和肾盂癌的分级和分期有关，P53、C－erbB－2基因蛋白和EGFR有显著相关关系。结果表明P53、C－erbB－2基因蛋白和EGFR对膀胱癌和肾盂癌的恶性程度和预后评估具有重要参考意义。     

女性尿失禁患者尿动力学检查的意义

对６８例女性尿失禁的临床诊断和尿动力学检查结果进行了比较研究。根据病史、主诉、体查和辅助检查而做出的诊断，各型尿失禁之间有１５．０％到２７．８％与尿动力学检查不一致。详细的病史、体检、辅助检查与尿动力学检查结果相结合，才能对尿失禁做出正确的诊断。尿动力学检查对于拟手术的患者或基于临床诊断治疗失败的患者具有重要意义。     

Is it possible to prevent bacterial adhesion onto ureteric stents?

The aim of this study was to determine whether the use of bactericidal coatings or immersion in antibiotic solution reduces or prevents bacterial adhesion onto ureteric stents. Precut segments of full silicone, silver-coated and hydrogel-coated ureteric stents were incubated with two uropathogenic bacterial strains with and without previous immersion in antibiotic solution. Tobramycin, ceftriaxone and ciprofloxacin solutions were used, as these antibiotics are commonly administered for the prophylaxis and treatment of urinary tract infection (UTI). Microbiological analysis showed that immersion of ureteric stents in ceftriaxone and ciprofloxacin yielded a significant reduction of bacterial adhesion, whereas immersion in tobramycin did not. The surface material of the stents had no direct influence on bacterial adhesion. In this experimental study, neither the silver nor the hydrogel coat reduced bacterial adhesion onto ureteric stents whereas immersion in a suitable antibiotic solution significantly reduced and even prevented this phenomenon, probably due to the adhesion of the antibiotic onto the stent surface. Prevention of bacterial adhesion onto ureteric stents is essential to reduce the risk of UTI in connection with these devices.     

Cavernous sinus thrombosis following odontogenic and cervicofacial infection

Summary Cavernous sinus thrombosis (CST) is rarely seen clinically as a complication of infectious processes since the discovery of penicillin. At the present time, dental abscess is an uncommon cause of CST. We now report our experiences with a 60-year-old diabetic male, who developed CST 38 days after extraction of an infected upper third molar tooth. The importance of eradicating regional cervicofacial foci of infection is stressed.     

烧伤病人创面感染气单胞菌的研究

从521份气单胞菌所致烧伤病人创面感染的创面标本中,经生化反应分析、毒素测定,检出气单胞菌42株(80.06％),其菌种为亲水气单胞菌24株(57.14％),温合气单胞17株(40.5％),豚鼠气单胞菌1株(2.36％)。在42株气单胞菌感染中,单一菌种感染15株(35.7％),多种菌感染27株(64.3％)。     

发热门诊的感染控制

笔者介绍了我院发热门诊的特点以及特殊规定，为加强控制感染，我院要求对发热门诊人员进行培训、体检，实行军地患者分开诊治，重视消毒隔离工作，发热门诊人员集中居住，无关人员禁入发热门诊，制订了严格的规章制度及就诊流程图。经过严格的控制，我院发热门诊运转正常，发热门诊无交叉感染出现。     

从早产儿脐带血中分离出流行性出血热病毒的探讨

１９９２年１２月作者从一位ＥＨＦ患者的早产儿脐带血中分离出ＥＨＦＶ，证实ＥＨＦＶ沿母、婴垂直途径传播的可能性。     

泌尿系感染者病原菌及耐药性分析

目的：了解近年来泌尿系细菌感染致病菌及耐药性，为合理应用抗生素，提供临床根据。方法：对泌尿系感染患者298株病原菌进行药物敏感试验。结果：大肠埃希菌仍是引发泌尿系感染的主要病原菌，占53％，其次是葡萄球菌属，占19．40％，肠杆菌属占10．06％，肠球菌属占4．70％等，各类菌属耐药情况。结论：临床医师必须关注本地病原菌分布及耐药情况，合理应用抗生素，减少耐药性播散。