Chronic occupational exposure to organic solvents

Summary Twenty-two persons (20 men and 2 women) were examined for their external and internal exposure to the glycol ether 1-methoxypropan-2-ol (PGME) during the production, leak testing and mounting of brake-hoses. For the measurement of external exposure, personal air monitoring was the method of choice. Average concentrations of PGME of 82.2 mg/m³ (22.3 ppm), 68.6 mg/m³ (18.6 ppm) and 11.3 mg/m³ (3.1 ppm) were found in the air of the brakehose production, leak test and mounting areas, respectively. For the estimation of internal exposure to PGME, this glycol ether was measured in both urine and blood. The biological samples were taken post-shift. The highest internal exposure levels were found in the brakehose production section and in the leak test area. The average post-shift concentrations for PGME in workers in the brakehose production section were 4.6 mg/l in urine and 13.5 mg/l in blood; the corresponding figures for workers in the leak test area were 4.2 mg/l in urine and 11.0 mg/l in blood. In blood and urine samples of workers engaged in the mounting area, PGME levels were below the detection limits. The elimination kinetics of PGME were also studied in three highly exposed persons, and mean excretion half-lives of PGME of approximately 4.4 h were found. On the basis of our results we made a rough calculation of a future biological tolerance value: we would except that concentrations of 38-109 mg per litre of blood and 10–31 mg per litre of urine would correspond to the German MAK value for PGME (375 mg/m³).     

脑电分频积分定量法测定甜菜碱对清醒家兔脑电图的影响

本文采用脑电分频积分定量法测定甜菜碱对清醒家兔脑电的影响。清醒家兔静注甜菜碱250mg/kg后,出现高幅幔波夹杂低幅快波脑电,自发脑电积分值((?)vs)显著提高。动物安静少动。结果表明甜菜碱有中枢抑制作用。     

一种拥有自主知识产权的国产可膨胀阴茎假体

勃起功能障碍是常见的男性疾病，部分ED患者在非手术治疗无效后，最终将植入阴茎假体进行治疗，且可获得满意的效果。本文简述这种疾病现状及其治疗方法，介绍一种拥有自主知识产权的国产阴茎假体的特征及其临床应用情况。     

The pitfalls of the dexamethasone suppression test: A biological marker of endogenous depression?

In the past few years there have been numerous publications which have stressed the value of the dexamethasone suppression test (DST) as a diagnostic marker of endogenous depression. Our own studies in 333 psychiatric inpatients and 121 healthy subjects did not reveal a differential diagnostic use for the DST. This result is in good agreement with other results in the literature. Our data demonstrate that intervening variables such as severity of illness, weight loss, sleep disturbances, situational stress, drug and alcohol withdrawal, and the pharmacokinetics of dexamethasone have an important influence on DST results, regardless of the diagnostic classification.     

粤西地区血小板聚集率正常人群参考范围的建立

目的 :为粤西地区血小板聚集率的临床检测提供参考标准。方法 :采用北京普利生仪器有限公司生产的 L BY-NJ型多功能血液凝聚仪。以终浓度 2 .5 μmol/ L ADP为诱导剂 ,对 6 38例正常人按年龄、性别分组 ,分别检测血小板 1m in、3min、5 min及 Max聚集率 ,并进行统计学分析。结果 :各年龄组男女性别 PAG无显著性差异 ( P>0 .0 5 ) ;小于 35岁年龄组与 35～ 5 5岁年龄组比较 ,PAG无显著性差异 ( P>0 .0 5 ) ;35～ 5 5岁年龄组与大于等于 5 5岁年龄组比较 ,1min及 3mim PAG存在显著性差异 ( P<0 .0 5 )、5 min及 Max PAG相差非常显著 ( P<0 .0 1) ;小于 35岁年龄组与大于等于5 5岁年龄组比较 ,PAG有非常显著性差异 ( P<0 .0 1) ;小于 5 5岁年龄组与大于等于 5 5岁年龄组比较 ,PAG差异有极显著性意义 ( P<0 .0 1或 P<0 .0 0 1)。结论 :5 5岁以上年龄组与 5 5岁以下年龄组的 PAG结果 ,可作为粤西地区同类方法PAGT的正常参考值供临床检测参考     

CR临床应用的几点体会

众所周知，CR是将透过人体的X线影像信息记录于影像板(image plate，IP)而不是记录在胶片上。记录在IP上的影像信息要经过读取处理和显示等步骤才能显示数字化图像。CR的设备，除X线机以外，主要有IP影像读取装置，影像存储和显示装置，以及控制用的计算机。     

fMRI技术在脑胶质瘤的应用体会

目的:利用血氧水平依赖法(BOL D)成像对患者脑胶质瘤并可能累及脑皮层功能区的患者进行功能磁共振成像(f MRI)检查,有助于外科治疗方案的制定,以提高手术的成功率和治愈率,避免重要脑功能中枢受到损伤。方法:对12例患有脑胶质瘤的患者用双手对指刺激的方法实行动态MR脑功能成像,共计5 0个动态,每次10个动态,18个层面,扫描时间为15 9s,分别间隔以等时间的静息期,检测感兴趣区正相关系数。结果:12例患者的图像采集满意,激活区均激活边缘系统,丘脑区,激活的脑功能区包括初级和次级躯体感觉区,尤以脑胶质瘤对侧激活最为显著(8例) ,同侧也有部分激活(4例)。结论:左右手对指激活特定的脑功能区,表明患者今后的恢复功能可能是对侧功能的代偿。这对外科制定手术方案,恢复的评估以及避免脑神经功能区的损伤有一定的指导意义。     

肛肠肌电图对盆底疾病的诊断价值(附360例报告)

对3组患者均检查耻骨直肠肌,肛门内,外括约肌共1098块肉,共检测67880个运动单位电位。结果表明:便秘组肌电异常占82.2％(226/275),肿瘤术后组异常率为66.7％(14/24),脊髓病变组肌电异常率为98.4％(60/61),亦初步探讨肌电图对盆底疾病的诊断价值。     

Quantifying arbitrary magnetic susceptibility distributions with MR.

Magnetic susceptibility, as a physical property of materials, plays important roles in many physical, chemical, engineering, and medical applications. Its quantification becomes of significant interest when MRI becomes a commonly used technique in biomedical applications. A general method is presented here for quantifying arbitrary magnetic susceptibility distributions in a localized region on the basis of first principles of magnetic induction field distributions in space. A proof of the concept was demonstrated by computer simulations. The study establishes the methodological basis for quantitative magnetic susceptibility imaging with MR.