透析后中药保留灌肠治疗慢性结肠炎的临床分析

目的观察结肠透析机清洗结肠后,进行中药汤剂保留灌肠治疗慢性结肠炎的临床疗效及并发症。方法随机将慢性结肠炎病人96例分成两组,治疗组49例,对照组47例,治疗组先采用透析机对结肠进行充分清洗,然后将浓缩的中药汁200～250ml进行灌注,并保留半小时以上,每天1次,治疗2周。对照组采用传统手工清洁浣肠后用同样的中药汁200～250ml进行保留灌肠,至少半小时以上,每天1次,治疗2周。结果治疗组41例症状完全缓解,随访半年无复发,7例临床症状部分缓解,1例症状未缓解。对照组28例症状完全缓解,半年以后无复发,14例症状部分缓解,5例症状未缓解,两组均无并发症。结论结肠透析机清洗结肠配合中药汤剂保留灌肠治疗慢性结肠炎,疗效明显好于传统的中药汤剂灌肠,且复发率大为降低,经济安全。     

外用溃疡散保留灌肠治疗肛门疾病术后并发症的临床观察

为探讨外用溃疡散保留灌肠治疗肛门疾病术后并发症的效果,我们对肛门疾病术后采用外用溃疡散（41例,治疗组）、锡类散（34例,对照Ⅰ组）和滑石粉（30例,对照Ⅱ组）灌肠的105例患者的术后症状评分进行回顾性分析,并进行对比研究。结果显示,治疗组手术后第7天疼痛、出血、水肿及下坠感、分泌物评分明显低于对照Ⅰ组,P〈0．05;手术后第3天和第7天疼痛、出血、水肿及下坠感、分泌物评分明显低于对照Ⅱ组,P〈0．05。结果表明,肛门疾病术后外用溃疡散保留灌肠能明显减轻术后并发症。     

LRP1 modulates APP trafficking along early compartments of the secretory pathway

The amyloid beta peptide (Aβ) is a central player in Alzheimer's disease (AD) pathology. Aβ liberation depends on APP cleavage by β- and γ-secretases. The low density lipoprotein receptor related protein 1 (LRP1) was shown to mediate APP processing at multiple steps. Newly synthesized LRP1 can interact with APP, implying an interaction between these two proteins early in the secretory pathway. We wanted to investigate whether LRP1 mediates APP trafficking along the secretory pathway, and, if so, whether it affects APP processing. Indeed, the early trafficking of APP within the secretory pathway is strongly influenced by its interaction with the C-terminal domain of LRP1. The LRP1-construct expressing an ER-retention motif, LRP-CT KKAA, had the capacity to retard APP traffic to early secretory compartments. In addition, we provide evidence that APP metabolism occurs in close conjunction with LRP1 trafficking, highlighting a new role of lipoprotein receptors in neurodegenerative diseases.     

Remediation: Using Data to Prescribe Interventions for Nursing Students

This article presents the use of standardized assessments to prescribe remediation plans for midprogram and end-of-program nursing students. Remediation plans implemented for prelicensure students included a required relearning seminar taught by nurse educators. The midprogram students completed a 1-day relearning seminar and handwritten summaries and submitted concept maps for content areas in which they scored low in the assessments. End-of-program students completed a 2-day seminar and an 8-week asynchronous National Council Licensure Examination-Registered Nurses (NCLEX-RN) review course to determine NCLEX-RN readiness.     

Unconditioned Stimulus Intensity and Retention Interval Effects

In single-element taste-aversion learning, retention interval effects are seen if taste aversions are paradoxically weak when they are tested 1 day after conditioning than when they are tested 3 or more days after conditioning. One explanation of this phenomenon is that weaker taste aversions may increase in strength across a retention interval. To test this possibility, rats were given saccharin followed by an unconditioned stimulus (US) of weak, medium, or high intensity; testing occurred after a 1-day or a 5-day retention interval. The results showed retention-interval effects only at medium and high dosage levels, but not following a weak-intensity US. Furthermore, at the 5-day retention interval, aversion strength increased as the intensity of the US increased. However, at the 1-day retention interval, there were no significant differences due to US intensity. In accordance with previous experiments, this outcome suggests that nonassociative factors, such as US novelty, and not associative factors (e.g., US intensity), modulate taste aversion performance on a 1-day test.     

水合氯醛保留灌肠导管插入长度的探讨

随机将６０例惊厥患儿分为实验组、对照组，每组３０例，行水合氯醛保留灌肠时，导管插入深度分别为２０ｃｍ～２５ｃｍ、１５ｃｍ～２０ｃｍ。结果显示：止惊效果实验组优于对照组，经统计学处理，两组差异有显著性（Ｐ＜０．０５）。     

水胶体敷料在早产儿PICC置管中的应用研究

目的 探讨水胶体敷料结合3M透明敷贴“三明治”式固定早产儿PICC导管的临床应用效果。方法选择150例PICC置管的早产儿为研究对象,按入院顺序随机分为观察组和对照组各75例。观察组采用水胶体敷料结合3M透明敷贴“三明治”式固定PICC导管,对照组采用3M透明敷贴常规固定PICC导管。比较两组PICC留置的时间及穿刺周围局部皮肤情况（包括皮肤机械性损伤、过敏性皮炎、静脉炎及局部皮肤压疮等）。结果 观察组PICC留置的时间明显长于对照组（P〈0.05）;两组皮肤机械性损伤、过敏性皮炎、静脉炎及局部皮肤压疮等情况的比较,观察组均低于对照组,各指标组间比较差异均有统计学意义（P〈0.05）。结论 水胶体敷料结合3M透明敷贴“三明治”式固定早产儿PICC导管,不仅能妥善固定PICC导管,而且还能保护局部皮肤,避免局部机械性损伤、过敏性皮炎及皮肤压疮等情况的发生,还可以预防或减轻PICC置管后静脉炎的发生,延长置管时间。     

自酸蚀粘结剂在磨牙窝沟封闭中的临床应用效果分析

目的：观察使用自酸蚀粘结剂对磨牙窝沟封闭的临床效果。方法：选择50例8岁儿童、完全萌出的第一磨牙100颗,采用自身对照方法,随机方法一侧采用自酸蚀粘结剂处理（实验组）和另一侧采用磷酸酸蚀（对照组）的方法进行窝沟封闭,记录操作时间,术后3、6、12、24个月随访,观察封闭剂保留率。用χ2检验和t检验对数据进行统计分析。结果：实验组操作时间（121±8） s,对照组的操作时间（225±14） s,两组对比差异有统计学意义（ P＜0.05）。术后3、6、12、24个月复查,实验组和对照组窝沟封闭剂保留率无统计学差异（P＞0.05）。结论：应用自酸蚀系统进行窝沟封闭,操作时间短,窝沟封闭剂保留率高,能有效预防龋病的发生。     

复方丹参滴注并早期清胰汤灌肠与施他宁治疗重症急性胰腺炎的疗效及成本效益比较

目的比较复方丹参静脉滴注和清胰汤早期保留灌肠联合应用与施他宁治疗重症急性胰腺炎（SAP）的疗效及成本效益,探讨非手术治疗SAP有效且价廉的方法。方法将64例SAP患者随机分为治疗组（复方丹参静脉滴注和清胰汤早期保留灌肠）与对照组（施他宁）,对SAP患者的临床症状改善时间、血清淀粉酶和血常规复常时间、住院天数和住院直接费用、最终病死率以及治疗后患者腹腔内高压（IAH）缓解时间进行比较。结果治疗组腹痛初步缓解时间、首次排大便时间、恢复进食时间较对照组明显缩短,住院费用、住院天数大幅度减少,差异有统计学意义（P〈0．05）。腹部压痛体征消除时间、血清淀粉酶和血常规复常时间两组比较差异无统计学意义。SAP患者经治疗后IAH缓解时间,治疗组较对照组明显提前（P〈0．05）。两组最终病死率比较差异无统计学意义。结论复方丹参滴注和清胰汤早期保留灌肠联合应用,可明显改善SAP病情,减少住院天数,住院费用比施他宁更低。能比施他宁更快地缓解IAH,病死率则差异无统计学意义。