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61.
F. Benfenati L. F. Agnati K. Fuxe 《Journal of neural transmission (Vienna, Austria : 1996)》1988,71(2):143-158
Summary Experimentally induced changes in neurotransmitter receptors have been analyzed by means of a computer assisted simulation procedure over a wide range of free ligand concentrations. This approach allows to evaluate, for a given range of ligand concentrations, the relative influence of simultaneous variations in binding parameters (i.e. dissociation constant or Kd and in maximal number of binding sites or Bm) and to predict the net and final effect of the experimental condition on the receptor-mediated transmission line. The function representing the changes in bound values versus the respective free ligand concentrations, has been studied analytically on the basis of all the possible values that the percent changes in both Kd and Bm parameters induced by a given experimental condition can assume. A well characterized change in the pattern of bound radioligand could in this way be defined. This approach, developed to show in an immediate and clear way treatment-induce changes in receptor populations or to fit directly rough experimental data expressed as differences in bound values versus free ligand concentrations, seems to be an useful complement to the widely used saturation analysis of binding data. 相似文献
62.
宇宙射线斗子成像检测技术具有穿透力强、对高Z材料敏感等特点,特别适合检测特殊核材料,是监控核材料走私的有效方式之一。在搭建μ子成像检测硬件系统的同时,我们开发了一套针对实际硬件系统的模拟系统,并利用该系统开展斗子成像方法的研究。本文将介绍该模拟系统的有关情况,并给出利用该系统得到的仿真结果。相信这一工作将对实际宇宙射线μ子成像系统的设计给出指导意见。 相似文献
63.
Dirk Mayer Wolfgang Dreher Dieter Leibfritz Daniel M Spielman 《Magnetic resonance in medicine》2007,57(5):967-971
A numerical simulation tool was developed to calculate the echo amplitudes of J-coupled resonances within a series of radiofrequency (RF) refocused echoes. The signal modulation due to J-coupling in rapid acquisition with relaxation enhancement (RARE) is suppressed only when the inverse of the pulse interval (tau) is large compared to both the chemical shift (CS) difference (Deltadelta) of the coupled spins and the coupling constant. In contrast, the echo amplitudes in ultrafast low-flip-angle RARE (U-FLARE) oscillate around a quasi-steady-state value that is greater than zero (neglecting relaxation and diffusion) even when Deltadelta > 1/tau. The flip-angle distribution over the measured slice caused by the use of Gaussian-shape slice-selective refocusing pulses further reduces the echo oscillations. When the pulse interval falls short of the fast pulse rate regime, spectroscopic U-FLARE provides an improved spatial impulse response in the phase-encoding (PE) direction compared to spectroscopic RARE. 相似文献
64.
Graph algorithms previously developed by the authors are adapted to simulate pedigrees similar to those used in genetic linkage studies which associate disease phenotypes with specific genomic locations. Pedigrees are chosen uniformly at random from the set of those with specified numbers of individuals and matings and which contain no loops. Summary statistics from pedigrees generated in this way can be used to check real pedigrees for anomalies due to biased sampling or phenotypic effects on the pedigree structure. 相似文献
65.
Summary Based on the gate-related receptor hypothesis, an analysis of kinetics of AN-132, a new antiarrhythmic agent, blockade of
cardiac sodium channels and the gate-related receptor which is bound by the drug was performed by computer simulation. Model-predicted
apparent rates of onset of AN-132 (30 μmol/L) blocking were 0.051, 0.038, and 0.034 AF−1 at stimulation frequencies of 1.0, 2.0 and 3.0 Hz, respectively. The time constant of recovery from block by AN-132 at resting
potential -90 mV was 39.5 s. These findings are in agreement with those experimental data documented. The analysis of gate-related
receptor shows that AN-132 binds the inactivation gate-related receptor, and the binding and unbinding are modulated by the
inactivation process. 相似文献
66.
头低位模拟失重状态对前庭功能的影响 总被引:4,自引:1,他引:3
为研究头低位模拟失重对运动病症状、垂直视动眼震(VOKN)及体液重新分配的影响,在头低位-10°的模拟失重状态下,采用大视野的垂直视动刺激,观察18名正常人的运动病症状、VOKN、激素(AVP、VIP、CORT、ALDO)的反应特点。结果表明,头低位-10°状态下的大视野垂直视动刺激可以诱发出明显的运动病症状,头低位-10°的垂直视动刺激比坐位更容易诱发运动病。坐位状态VOKN慢相速度有明显的方向性不对称,敏感组VOKN方向性不对称有显著差异(P<0.05)。头低位-10°时VOKN的不对称现象不明显,向下方向运动的VOKN慢相速度显著增加。分析指出,头低位-10°状态下垂直视动刺激比坐位和秋千刺激的贡献率大。尿中CORT(皮质醇)在秋千和头低位的垂直视动刺激前后有显著性增加。提示:大视野的垂直视动刺激与头低位-10°两种刺激的结合可能成为预测空间运动病的方法之一. 相似文献
67.
Yukiya Hashimoto Toshiko Koue Yuko Otsuki Masato Yasuhara Ryohei Hori Ken-ichi Inui 《Journal of pharmacokinetics and pharmacodynamics》1995,23(2):205-216
A simulation study was conducted to compare the cost and performance of various models for population analysis of the steady
state pharmacokinetic data arising from a one-compartment model with Michaelis-Menten elimination. The usual Michaelis-Menten
model (MM) and its variants provide no estimate of the volume of distribution, and generally give poor estimates of the maximal
elimination rate and the Michaelis-Menten constant. The exact solution to the Michaelis-Menten differential equation (TRUE)
requires a precise analysis method designed for estimation of population pharmacokinetic parameters (the first-order conditional
estimation method) and also considerable computational time to estimate population mean parameters accurately. The one-compartment
model with dose-dependent clearance (DDCL), in conjunction with the first-order conditional estimation or Laplacian method,
ran approximately 20-fold faster than TRUE and gave accurate population mean parameters for a drug having a long biological
half-life relative to the dosing interval. These findings suggest that the well-known MM and its variants should be used carefully
for the analysis of blood concentrations of a drug with Michaelis-Menten elimination kinetics, and that TRUE, in conjunction
with a precise analysis method, should be considered for estimating population pharmacokinetic parameters. In addition, DDCL
is a promising alternative to TRUE with respect to computation time, when the dosing interval is short relative to the biological
half-life of a drug.
This work was supported in part by the Epilepsy Research Foundation, the Nakatomi Foundation, and a Grant-in-Aid for Scientific
Research from the Ministry of Education, Science, and Culture of Japan. 相似文献
68.
用赖氏法重复测丙氨酸氨基转移酶(ALT)标准曲线10次,计算机作线性回归和曲线拟合。直线回归结果,酶活性在不高于97U的范围内,相关系数(R)=0.999,斜率(b)+2.55×10^-3,截距(a)=0.0286;而达到200U时,R=0.086,b=1.90×10^-3,a=0.066,,显著性检验两者之间差别为极显著。表明:97U以下线性较好但不过原点,大于97U之后开始明显偏离该线性。拟合 相似文献
69.
片剂含量均匀度计量检验新方案的研究 总被引:5,自引:0,他引:5
本文通过大量测试工作,查明10批国产小剂量片剂的含量分布,在此基础上提出了计量检验新方案。采用计算机模拟随机抽样的方法,通过计算绘制了USP XX,BP,JP和新方案在正态分布和10批实际分布下的OC曲线。结果表明,当用于测定生产规模的片剂批时,与国外片剂含量均匀度计数检验方案中统计特性最优的USP XX方案相比,新方案NEW能在化验工作量相近的前提下,作出更准确的判断;新方案SMA能在不降低判断准确性的前提下,减少化验工作虽约三分之一。新方案还可减免分析方法误差对判定结果的影响。 相似文献
70.
吡那地尔对高血压心脏结构和功能重构的影响 总被引:5,自引:0,他引:5
在等降压剂量下吡那地尔和赖诺普利可使4月龄自发性高血压大鼠的血压下降6.0 ̄8.0kPa,并接近同种属正常血压大刀瓣血压水平。 相似文献