上颌窦开窗提升术的长期随访研究

目的:探讨上颌窭开窗植骨种植修复在上颌后牙骨量不足区的临床应用效果.方法:2002年2月至2006年11月.使用上颌窦开窗植骨种植修复上颌后牙缺失40倒,3例行双侧手术.其中男性29例,女性11例,平均年龄51.4岁(28～66岁).共植入84枚种植体.有38侧行上颌窦提升植骨同期种植;其余5侧行上颌窦提升植骨,延期种植.均采用埋入式愈合方式.均已完成上部结构修复,平均愈合期11.8个月(8～19个月),平均随访期为37.2个月(25～69个月).结果:植入的84枚种植体,在观察和随访期内均未发生松动,总存活率达100%.有4侧上颌窦在手术过程中发生粘膜穿破,但未发生上颌窦炎等并发症.随访期X线片显示种植体颈部无明显的骨透射影.结论:上颌窦开窗植骨种植修复技术安全可行,是解决上颌后牙骨高度不足区种植修复难题的有效方法.     

Immunomodulation by atorvastatin upregulates expression of gap junction proteins in coxsackievirus B3 (CVB3)-induced myocarditis

Objective  

To investigate the effect of atorvastatin on myocardial expression of gap junction proteins, connexins (Cxs), during coxsackievirus B3 (CVB3)-induced myocarditis.     

阻生下颌第三磨牙的治疗及并发症研究进展

<正>随人类的进化和食物的越来越精细,颌骨承受的负担减少,导致颌骨骨量减少,但牙的体积并不随之减少,最终使牙齿萌出的位置不足,第三磨牙阻生。第三磨牙阻生常引起冠周炎和第二磨牙的损害及其他疾病,多需拔除。由于阻生下颌第三磨牙,邻近重要的解剖结构、与邻牙关系密切,而造成手术难度较大。目前国际上对下颌阻生第三磨牙的研究很多,本文就国内外学者在下颌阻生第三磨牙的传统手术拔除方法、预防术后并发症的新方法、阻生磨牙     

Surface engineering of titanium with potassium hydroxide and its effects on the growth behavior of mesenchymal stem cells

To improve the corrosion resistance and biological performance of commercially pure titanium (cp-Ti) substrates, potassium hydroxide was employed to modify the surfaces of titanium substrates, followed by biomimetic deposition of apatite on the substrates in a simulated body fluid. The morphologies of native and treated titanium substrates were characterized by field emission scanning electron microscopy (FE-SEM). Treatment with potassium hydroxide led to the formation of intermediate layers of potassium titanate on the surfaces of titanium substrates, while apatite was subsequently deposited onto the intermediate layer. The formation of potassium titanate and apatite was confirmed by thin-film X-ray diffraction and FE-SEM equipped with energy dispersive spectroscopy, respectively. Electrochemical impedance spectroscopy showed that the formed potassium titanate layer improved the corrosion-resistance properties of titanium substrates. The influence of modified titanium substrates on the biological behavior of mesenchymal stem cells (MSCs), including osteogenic differentiation, was investigated in vitro. Compared with cp-Ti substrates, MSCs cultured onto alkali- and heat-treated titanium substrates and apatite-deposited titanium substrates displayed significantly higher (P < 0.05 or P < 0.01) proliferation and differentiation levels of alkaline phosphatase and osteocalcin in 7 and 14 day cultures, respectively. More importantly, our results suggest that the modified titanium substrates have great potential for inducing MSCs to differentiate into osteoblasts. The approach presented here may be exploited to fabricate titanium-based implants.     

复方替硝唑栓剂体内外抗阴道毛滴虫研究

目的观察复方替硝唑栓剂的体内外抗阴道毛滴虫作用。方法将临床确诊的滴虫性阴道炎患者100例随机分为两纽，试验纽用复方替硝唑栓治疗，对照组用双唑泰栓治疗，每晚睡前放入阴道1粒。6d为1个疗程，共治疗2个疗程；选用临床分离的阴道毛滴虫9株。观察复方替硝唑栓的体外抗阴道毛滴虫作用。结果临床治愈率复方替硝唑栓为100％，双唑泰栓为78．7％，两者有显著性差异（P〈0．05）；复方替硝唑栓体外抗阴道毛滴虫的抑虫50％浓度（MIC50）、抑虫90％浓度（MIC50）厦最低杀虫浓度（MBC）范围均低于双唑泰栓。结论复方替硝唑检体内外抗阴道毛滴虫作用显著．比双唑泰栓疗效更佳。     

特发性血小板减少性紫癜患者激素敏感性与糖皮质激素受体亚型的关系研究

目的探究特发性血小板减少性紫癜（ITP）患者对糖皮质激素敏感性与其外周血单个核细胞内激素受体亚型表达的关系。方法采用实时定量RT—PCR和免疫组化技术检测不同激素敏感性ITP患者（包括糖皮质激素抵抗和敏感病人）外周血单个核细胞内α和β亚型糖皮质激素受体（GRα和GRβ）mRNA和蛋白表达，并将检测结果与正常对照组进行比较。结果糖皮质激素抵抗组患者外周血单个核细胞GRβmRNA表达量和GRβ蛋白表达阳性的单个核细胞比率明显高于激素敏感组及正常对照组（P〈0．01），而GRα mRNA和蛋白表达水平，各组之间无显著差异。结论ITP患者糖皮质激素敏感性与其GRβ表达水平密切相关。     

Multicellular-mediated resistance to cisplatin and taxol in human ovarian cancer SK-OV-3IP1 multicellular aggregates

Chemotherapy is playing an increasingly important role in treatment of patients with advanced ovarian cancer. However, multidrug resistance (MDR) whether intrinsic or acquired- remains one of the most significant obstacles to survival improvement. A number of possible mechanisms have been put forward to account for drug resistance[1]. However, most of these proposed mechanisms are based largely on the study of drug- resistant variants isolated from tumor cell lines exposed to various classes …     

补肾益气中药对溴隐亭致流产大鼠蜕膜Th1/Th2型细胞因子的影响

目的:探讨补肾益气中药对流产大鼠的保胎机理。方法:采用孕6、7、8天皮下注射溴隐亭0.125mg/d 诱发 SD 大鼠流产模型,以半定量逆转录多聚酶链式反应(RT-PCR)方法测蜕膜 Th1/Th2型细胞因子的表达,观察中药治疗对以上指标的影响。结果:补肾益气中药可使溴隐亭致流产大鼠蜕膜 Th1/Th2型细胞因子平衡恢复正常。结论:中药可通过对母胎界面 Th1/Th2型细胞因子平衡的调控维持妊娠。