中风后抑郁患者的护理干预

目的探讨中风后抑郁患者护理干预措施的效果。方法选取我科2011年1月～2012年6月收治的中风患者100例,随机分为常规组与试验组各50例,常规组患者给予常规的护理措施,试验组患者则在常规护理措施的基础上重点加强康复及心理护理。结果试验组患者抑郁症状改善明显好于常规组。结论适当有效的护理干预可明显改善中风后抑郁患者的不良心理状态。     

腹腔镜脾切除联合贲门周围血管离断术的临床应用

目的:探讨腹腔镜脾切除联合贲门周围血管离断术的方法、安全性和有效性。方法:回顾分析2006年10月至2007年10月我院为10例患者行腹腔镜脾切除联合贲门周围血管离断术的临床资料。结果:10例均成功完成腹腔镜手术,手术时间180～270min,平均(200±30)min,术中出血300～1500ml,平均(400±60)ml。结论:完全腹腔镜脾切除联合贲门周围血管离断术安全可行。     

COX-2 expression in gastric cancer and its relationship with angiogenesis using tissue microarray

AIM： To explore the expression and clinicopathological significance of cyclooxygenase-2 （COX-2） and microvessel density （MVD） in gastric carcinogenesis, and to investigate their roles in the invasion and the relationship between biological behaviors and prognosis of gastric cancer.
METHODS： Using Envision immunohistochemistry, COX-2 and CD34 expressions in gastric cancer tissue array were examined. MVD was counted and the relationship between the biological behaviors and prognosis was analyzed.
RESULTS： The expression of COX-2 in gastric cancer tissue was significantly higher than that in normal mucosa （χ^2 = 12.191, P 〈 0.05）. The over-expression of COX-2 in gastric cancer was obviously related to metastasis and depth of invasion （χ^2 = 6.315, P 〈 0.05）, but not related to the histological type and Borrmann type （χ^2 = 5.391 and χ^2= 2.228, respectively）. Moreover, MVD in gastric cancer tissues was significantly higher than that in the normal mucosa （65.49 ± 20.64 vs 36.21 ± 18.47, t/F = 7.53, P 〈 0. 05）. MVD was related to the histologic type and metastasis （t/F= 3.68 and t/F = 4.214, respectively, P 〈 0. 05）, but not related to the depth of invasion and Borrmann type （t/F = 0.583 and t/F = 0.459, respectively）. MVD in COX-2-positive tissues was markedly higher compared to COX-2-negative tissues, indicating a positive correlation between COX-2 expression and MVD （t = 13.12, P 〈 0. 05）.
CONCLUSION： Tissue microarray （TMA） is a powerful tool for rapid identification of the molecular alterations in gastric cancer. COX-2 expression, via inducingangiogenesis, may play an important role in gastric carcinogenesis. It could be served as a determinant factor for clinical prognosis and curative effect.     

Sonochemically prepared BSA microspheres containing Gemcitabine,and their potential application in renal cancer therapeutics

This report demonstrates the formation and characterization of sonochemically prepared bovine serum albumin (BSA)–Gemzar (Gemcitabine) microspheres and shows their increased anticancer activity compared to pristine Gemzar. The amount of loaded Gemzar was determined by light absorption measurements. The BSA–Gemzar composite was analyzed and characterized by optical microscopy and scanning electron microscopy. The release kinetics of Gemzar from the proteinaceous microspheres was tested. The BSA–Gemzar composite was examined for its anticancer activity (in vitro) in renal cancer cells (RCC, 786-O cells) using [³H]thymidine incorporation assays. It was found that the influence of the Gemzar-loaded microspheres on the cancer cells was significantly greater than that of an equimolar concentration of pristine Gemzar.     

我国医疗服务质量监管现状及对策研究

在界定医疗服务质量监管概念的基础上,结合监管相关理论分析了我国医疗服务质量监管体系松散、实际监管主体单一、监管标准不够科学、监管结论利用不足、监管模式选取不合理等问题,并提出培育监管主体、建立监管主体的互联协调机制、创新体制机制、制定科学的监管标准和监管计划等手段以提高医疗服务质量监管的有效性和效率。     

关于体温不高发热机制的中西医探讨

＂发热待查＂是大多数患者就诊时常见的临床诊断,对其机制的研究是有极大的临床意义的。现在西医多用体温调定点学说来解释发热的机制,但用该学说来解释中医学里的＂五心烦热＂、＂潮热＂、＂骨蒸发热＂等低热现象时就显得捉襟见肘,而将体温不高的发热归属于功能性疾病,鉴于西医对功能性疾病的发病机制不甚清楚,故着重用中医对体温不高的发热机制进行了探讨,扩充了有关发热机制的理论知识。     

肺癌组织中低氧诱导因子1α的表达及其与肿瘤耐药关系

目的 探讨肺癌组织中低氧诱导因子1α(HIF-1α)、多药耐药相关蛋白1(MRP1)和谷胱甘肽S转移酶-π(GST-π)的表达及其相关性.方法 采用免疫组织化学方法检测53例肺癌组织中HIF-1α、MRP1和GST-π的表达水平.比较不同肺癌浸润程度、有无淋巴结转移者HIF-1α、MRP1和GST-π的阳性表达情况.结果 53例肺癌组织中HIF-1α阳性表达44例(83.0%),GST-π阳性表达28例(52.8%),两者呈正相关(P＜0.05),HIF-1α表达与MRP1表达(阳性表达31例,为58.5%)无相关性(P＞0.05).肺癌TNM分期T3、T4组HIF-1α、MRP1和GST-π高表达率分别为60.0%、80.0%和73.3%,与T1、T2组的26.3%、44.7%和42.1%比较,差异均有统计学意义(P＜0.05).肺癌有淋巴结转移组HIF-1α、MRP1和GST-π高表达率分别为84.0%、72.0%、68.0%,与无淋巴结转移组的25.0%、42.9%和39.3%比较,差异均有统计学意义(P＜0.05).结论 HIF-1α可能对GST-π的表达起上调作用,HIF-1α、MRP1和GST-π高表达与肺癌的浸润程度和淋巴结转移有关.     

基于HL7的HIS与PACS／RIS集成

目的：将HIS与PACS／RIS集成,解决两套系统数据无法共享的问题,优化业务流程,满足医院日益增长的信息化需求。方法：通过利用医疗领域不同系统之间电子数据传输的标准协议HL7技术,开发HL7接口引擎,将两个系统紧密集成．实现数据完全共享。结果：HL7接口引擎开发完成后,解决了HIS与PACS／RIS的信息共享问题,提高了工作效率。结论：HL7技术成熟,符合国际标准,扩展性很好,既有助于提高诊疗质量,又能有效保证医院内部数据的一致性。