全文获取类型
收费全文 | 1172篇 |
免费 | 103篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 5篇 |
妇产科学 | 12篇 |
基础医学 | 101篇 |
口腔科学 | 32篇 |
临床医学 | 160篇 |
内科学 | 214篇 |
皮肤病学 | 25篇 |
神经病学 | 70篇 |
特种医学 | 42篇 |
外国民族医学 | 12篇 |
外科学 | 123篇 |
综合类 | 127篇 |
预防医学 | 45篇 |
眼科学 | 10篇 |
药学 | 108篇 |
4篇 | |
中国医学 | 55篇 |
肿瘤学 | 155篇 |
出版年
2024年 | 1篇 |
2023年 | 54篇 |
2022年 | 106篇 |
2021年 | 108篇 |
2020年 | 84篇 |
2019年 | 46篇 |
2018年 | 43篇 |
2017年 | 31篇 |
2016年 | 47篇 |
2015年 | 62篇 |
2014年 | 100篇 |
2013年 | 75篇 |
2012年 | 77篇 |
2011年 | 72篇 |
2010年 | 56篇 |
2009年 | 58篇 |
2008年 | 31篇 |
2007年 | 39篇 |
2006年 | 46篇 |
2005年 | 39篇 |
2004年 | 27篇 |
2003年 | 17篇 |
2002年 | 15篇 |
2001年 | 12篇 |
2000年 | 12篇 |
1999年 | 14篇 |
1998年 | 8篇 |
1997年 | 4篇 |
1996年 | 8篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
排序方式: 共有1300条查询结果,搜索用时 156 毫秒
1.
《Journal of Medical Imaging and Radiation Sciences》2022,53(3):460-470
PurposeTo provide means for calculating the dose received by various tissues of the patient, calculate lung shield, and verify received dose using a phantom as a tool for quality assurance for a planned Total Body Irradiation (TBI) procedure in radiotherapy.MethodUsing Microsoft Visual Basic, MATLAB, and Python, a program for Total Body Irradiation Calculation in Radiotherapy (TBICR) is constructed. It uses patient translation and beam zone method for total body irradiation calculations to compute the proper dose received by the patient and determine the lung shield thickness. There are three main user-friendly interfaces in the application. The first one allows the user to upload the TBI topography and estimate the distances needed for TBI calculations. The second one enables the user to count the number of beam zones needed for each point and estimate the effective area (Aeff) for each level. The third interface estimates the velocity required to deliver the relative dose depending on patient separation, Monitor Units (MU), couch speed and travel distance. It allows the user to compute the required lung shield thickness, read any patient's CT DICOM file and acquire dose in any distinct location using machine learning model to predict the dose.ResultsThe TBICR software has been successfully validated by reproducing all of the manual calculations in an exact and timely manner. TBICR generated more accurate results and confirmed the absorbed dose to patient through measurements on Anderson phantom.ConclusionsA computer program for the calculation of total body irradiation (TBI) is described in full. The dose received at each point on the patient, the calculation of lung shield and the determination of the velocity and time required for the couch movement are all made possible using the software. The ease of use, precision, data storage and printing are some important features of the present software. 相似文献
2.
3.
4.
5.
《European journal of surgical oncology》2020,46(6):1118-1123
AimTo investigate the impact of circumferential tumour location on neoadjuvant chemoradiotherapy (CRT) response and its prognostic value for locally advanced rectal cancer (LARC) patients after CRT and surgery.MethodsA retrospective study was performed on 486 patients with LARC who received neoadjuvant CRT and surgical treatment. The rate of pathological complete response (pCR) and survival among patients with anteriorly, laterally, and posteriorly located tumours were compared. Logistic regression was performed to identify pCR predictors.ResultsThe anterior tumours exhibited the highest pCR rate of 26.7%, which was slightly higher than the 20.0% and 12.3% for lateral and posterior tumours, respectively (P = 0.006). The 5-year Overall survival (OS) rates after CRT were similar among the anterior, lateral, and posterior groups (anterior vs lateral vs posterior: 81.1% vs 89.9% vs 84.1%, P = 0.6368). Multivariate analysis revealed that the circumferential tumour location, post-CRT serum CEA and post-CRT tumour thickness measured by MRI were independently correlated with achieving pCR.ConclusionThis study is the first, to the best of our knowledge, to show that anterior LARC exhibited the highest pCR rate after neoadjuvant CRT. Patients with anterior rectal cancers do not have different prognoses from those with non-anterior cancers if they undergo neoadjuvant CRT. 相似文献
6.
《European journal of surgical oncology》2020,46(6):1138-1143
IntroductionThe purpose of this study was to review recommendations made from a specialist pelvic exenteration (PE) multidisciplinary team (MDT) and to provide insights as to the impact of the MDT on patient selection and clinical decision making.Materials & methodsA retrospective review was conducted at Royal Prince Alfred Hospital's PE MDT between June 2014 and December 2015. Data was collected from the recorded minutes of MDT meetings. Referral information and clinical data was extracted from individual patient files. Additional data including operative dates and surgical resection margins were collected from electronic medical records.ResultsOf the 183 patients considered for PE during the MDT meeting, 104 (57%) were recommended for surgery. Factors that influenced the recommendation in favour of surgery were referral by a surgeon (P = 0.004), referral from a rural location (P = 0.05) and having locally advanced primary cancer (P < 0.001). Patients who were seen by the unit's surgeon prior to the MDT did not impact on the MDT recommendation nor the decision for or against surgery (P = 0.771). The most common reason for recommendation against PE was unresectable distant metastatic disease (43%).ConclusionsThe PE MDT meeting is a critical step in the patient care pathway and facilitates critical decision making. Anatomically-based contraindications to surgery (i.e. involvement of adjacent organs, bone and neurovascular structures) do not appear to influence MDT decision making regarding resectability. 相似文献
7.
8.
《Current problems in cancer》2020,44(6):100579
BackgroundWhether early gastric cancer with mixed histologic type should be considered for endoscopic submucosal dissection (ESD) remains controversial. The objective of this study was to evaluate the risk of lymph node metastasis (LNM) and prognostic significance for early gastric cancer with mixed histologic type.MethodsWe retrospectively reviewed clinicopathologic and survival data of 302 patients who underwent surgical resection for early gastric cancer. Based on the histologic components, all patients were classified as pure differentiated type, pure undifferentiated type and mixed histologic type. The prognostic differences between different types were compared and predictive factors for LNM were evaluated.ResultsHistopathologically, the proportion of mixed histologic type was 12.3% in early gastric cancer. In terms of LNM, mixed histologic type had a more frequent incidence than pure differentiated type (32.4% vs 11.1%, P < 0.01). However, there was no significant difference between mixed type and pure undifferentiated type for LNM (32.4% vs 21.1%, P = 0.139). Multivariate analysis revealed that tumor size >2 cm (odds ratio [OR]: 2.153, 95% confidence interval [CI]: 1.113-4.164, P < 0.05), submucosal invasion (OR: 3.881, 95%CI: 1.832-8.222, P < 0.001), lymphovascular invasion (OR: 8.797, 95% CI: 2.643-29.277, P < 0.001), undifferentiated type (OR: 3.146, 95% CI: 1.352-7.320, P < 0.01), and mixed histologic type (OR: 3.635, 95% CI: 1.272-10.390, P < 0.05) were independent risk factors for LNM in early gastric cancer patients. However, mixed histologic type did not affect the survival outcome of these patients (hazard ratio: 0.629, 95% CI: 0.074-5.311, P > 0.05).ConclusionMixed histologic type was an independent risk factor for lymph node metastasis in early gastric cancer patients. The decisions regarding endoscopic submucosal dissection for mixed histologic type should be carefully considered. 相似文献
9.
组织细胞坏死性淋巴结炎29例临床病理分析 总被引:4,自引:0,他引:4
目的:探讨组织细胞坏死性淋巴结炎(HNL)的临床病理特征。方法:回顾性分析29例HNL的临床资料,观察描述其病理特征;用S-P免疫组化法检测细胞表型。结果:HNL多见于年轻女性,颈部淋巴结肿大.高热,外周血WBC降低。活检标本常呈破碎状.淋巴结皮质、副皮质区可见片状或融合的凝固性坏死灶,坏死灶内可见嗜础胜核碎片和嗜酸性颗粒辟屑,伴有T细胞和组织细胞的大量增生,无中性粒细胞浸润,B细胞少量散在分布。结论:淋巴结肿大、高热,淋巴结内不伴有中性粒细胞浸润的散在或片状凝固性坏死及大量组织细胞增生为HNL的临床病理特征。 相似文献
10.
Catalina Balaguer Alexander Palou Alberto Alonso-Fernández 《Archivos de bronconeumologia》2009,45(9):449-458
Snoring and sleep apnea-hypopnea syndrome (SAHS) are two disorders of considerable relevance due to their high prevalence in the general population and their notable morbidity and mortality, particularly in association with their harmful effects on the cardiovascular system. As well as sex, age, weight, craniofacial malformations, alcohol consumption, and use of hypnotic drugs, it has been suggested that smoking may be a risk factor for developing sleep-disordered breathing. While there is solid evidence for the independent association between snoring and smoking in both children and adults, it is still unclear whether smoking constitutes an independent risk factor for developing SAHS, despite the many studies carried out to assess this link. This is probably because the association, if it exists, is very weak. 相似文献