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排序方式: 共有2219条查询结果,搜索用时 15 毫秒
1.
《Journal of clinical densitometry》2022,25(4):553-558
To explore the distribution of several bone metabolic indicators in type 2 diabetes patients (T2DM) with and without non-alcoholic fatty liver disease (NAFLD) and to preliminarily evaluate the relationship of bone metabolism with NAFLD in patients with T2DM. The hospitalized patients with T2DM were divided into the group of T2DM complicated with NAFLD and the group of T2DM alone according to the results of ultrasonic diagnosis. The general information and laboratory test data such as bone metabolism indexes of these patients were collected and the differences of the indexes between the 2 groups were compared. Furthermore, the independent influencing factors of NAFLD in patients with T2DM were analyzed. A total of 186 patients were included in the study. Compared with patients with T2DM only, patients with T2DM combined with NAFLD were characterized with younger age (p < 0.001), higher BMI (p = 0.016), ALT (p = 0.001), TG (p = 0.005), HOMA-IR (p = 0.005), and lower HDL-C (p = 0.031). Significant discrepancy of age (OR 1.052, p = 0.001), ALT (OR 0.964, p = 0.047), HOMA-IR (OR 0.801, p = 0.005), and T-PINP (OR 1.022, p = 0.008) was found using multivariate logistic regression model. Significant discrepancy of T-PINP was found in T2DM patients with and without NAFLD. Further studies are needed to explore whether T-PINP could be used as a predictor of fatty liver disease, osteoporosis, and other related complications in patients with T2DM. 相似文献
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《Journal of clinical densitometry》2022,25(4):485-489
Pubertal suppression with gonadotropin-releasing hormone (GnRH) agonists in transgender and gender non-conforming (TGNC) youth may affect acquisition of peak bone mass. Bone marrow adipose tissue (BMAT) has an inverse relationship with bone mineral density (BMD). To evaluate the effect of pubertal suppression on BMAT, in this pilot study we prospectively studied TGNC youth undergoing pubertal suppression and cisgender control participants with similar pubertal status over a 12-month period. BMD was measured by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Magnetic Resonance T1 relaxometry (T1-R) and spectroscopy (MRS) were performed to quantify BMAT at the distal femur. We compared the change in BMD, T1-R values, and MRS lipid indices between the two groups. Six TGNC (two assigned female and four assigned male at birth) and three female control participants (mean age 10.9 and 11.7 years, respectively) were enrolled. The mean lumbar spine BMD Z-score declined by 0.29 in the TGNC group, but increased by 0.48 in controls (between-group difference 0.77, 95% CI: 0.05, 1.45). Similar findings were observed with the change in trabecular volumetric BMD at the 3% tibia site (-4.1% in TGNC, +3.2% in controls, between-group difference 7.3%, 95% CI: 0.5%-14%). Distal femur T1 values declined (indicative of increased BMAT) by 7.9% in the TGNC group, but increased by 2.1% in controls (between-group difference 10%, 95% CI: -12.7%, 32.6%). Marrow lipid fraction by MRS increased by 8.4% in the TGNC group, but declined by 0.1% in controls (between-group difference 8.5%, 95% CI: -50.2%, 33.0%). In conclusion, we observed lower bone mass acquisition and greater increases in BMAT indices by MRI and MRS in TGNC youth after 12 months of GnRH agonists compared with control participants. Early changes in BMAT may underlie an alteration in bone mass acquisition with pubertal suppression, including alterations in mesenchymal stem cells within marrow. 相似文献
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经咽后入路手术治疗Hangman骨折 总被引:1,自引:1,他引:0
目的探讨Hangman骨折经咽后入路减压融合内固定的临床疗效。方法对7例Hangman骨折患者行颅骨牵引大致复位后择期手术。全麻下采用高位前方咽后入路显露C2-3椎体,切除C2-3椎间盘组织,充分减压,C2-3椎间植骨钢板内固定。术后颈围保护6~8周。结果7例均获随访,时间4—42个月。患者术后3个月内均获骨性愈合,无一例出现椎体再位移和成角畸形,无伤口感染及其他并发症发生,不全瘫患者均有不同程度恢复。结论C2-3前路减压融合内固定治疗Hangman骨折,内固定疗效确切,并能有效维持理想的复位。 相似文献
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尺骨鹰嘴骨折皮质骨加压螺钉固定的实验研究及临床应用 总被引:2,自引:0,他引:2
比较尺骨鹰嘴骨折加压螺钉与常用的4种内固定的强度,为临床选择内固定方法提供实验依据。用22具新鲜尸体肘关节做成横型、斜形和粉碎形鹰嘴骨折模型。用5种内固定后置于MD—10E万能电子力学试验机上,测定骨折处的位移与压力的关系;结果:钢丝内固定强度最小,钩钢板最大。髓内加压螺钉固定欠可靠。横形骨折皮质骨加压螺钉与张力带钢丝比较,统计学上无显著差异(P〉0.05),斜形骨折皮质骨加压螺丝钉强于张力带钢丝(P〈0.01)。粉碎形骨折使用钩钢板尤佳(P〈0.01)。临床应用24例中,22例平均随访14个月。骨折全部愈合,优良率达90.91%;认为皮质骨加压螺丝钉治疗横、斜形尺骨鹰嘴骨折,创伤小,操作简便,固定确切,是一种安全可靠的方法。 相似文献
8.
目的对比研究记忆合金网球植入与单纯减压植骨两种方法治疗成人股骨头缺血性坏死的疗效.方法成人股骨头缺血性坏死(FicatⅡ~Ⅲ期)45例,分别采用记忆合金网球植入和单纯减压植骨+股方肌骨瓣移植治疗,网球组23例26髋,减压植骨组22例26髋,分别观察两组病例的手术时间,术中出血量,术后髋关节的功能评分.结果网球组和减压植骨组的手术时间和出血量,分别为62.4±20.5
min、50.8±16.6 min(P<0.05)和180.6±38.5 ml、169.9±45.8 ml(P>0.05),术后所有病例经平均32个月随访,采用百分评分法评价,网球组的优良率为88.4%,减压植骨组的优良率为53.8%(P<0.05).结论记忆合金网球植入能增加股骨头的机械支撑力,重建股骨头血运,延长股骨头的使用年限. 相似文献
9.
钢板结合异体骨板治疗股骨干内固定术后再骨折 总被引:5,自引:2,他引:3
目的:探讨钢板结合异体骨板治疗股骨干钢板内固定术后再骨折的疗效。方法:股骨干钢板内固定术后再骨折13例,其中男8例,女5例;年龄14~57岁,平均31.2岁。粉碎性骨折7例,斜形骨折4例,横形骨折2例。8孔股骨有限接触加压钢板5例,8孔上肢有限接触加压钢板2例,6孔股骨有限接触加压钢板2例,8孔兰氏钢板4例。钢板断裂均发生在骨折端邻近钉孔处。全部采用有限接触加压钢板(LC-DCP)加对侧异体脱蛋白骨板股骨双固定及自体髂骨移植术。结果:13例均获得随访,时间16~40个月,平均32个月,平均骨折愈合时间为9个月,均恢复下肢行走和负重的功能。术后1年膝关节功能按Merchan标准评定:优7例,良4例,可1例,差1例,优良率84.6%(11/13)。结论:自体髂骨植骨钢板结合骨板内固定治疗股骨干再骨折效果好,可以达到骨折牢固固定的目的。 相似文献
10.
[目的]建立猪腰段脊髓火器伤模型和改良Allen's打击伤后全瘫模型,观察伤后肾脏病理和肾功能的早期变化。[方法]动物随机分为两组,火器伤组(G)6只,在全麻状态下做L1-2脊髓火器伤模型;打击伤组(A)6只,L1节段脊髓行改良Allen's打击。两组动物分别于伤前(0h)、伤后0.5h、1h、2h、4h检测血肌酐和血尿素氮(BUN)。死亡动物行肾脏病理检查。[结果]A组BUN值在伤后4h升高,G组BUN值在伤后1h升高。两组肌酐在伤后0.5h升高,各点监测G组明显高于A组。G组动物伤后5.2h-7.5h死亡,死亡率为100%。病理检查示G组肾包膜及肾实质广泛充血、出血。[结论]G组火器伤较A组肾脏损伤及组织破坏严重,在伤后早期出现肾功能变化。脊髓火器伤后肾功能变化早期应给予积极处理,以降低早期死亡率。 相似文献