创伤后多器官功能不全综合征抗炎症反应和免疫抑制

目的　研究创伤后多器官功能不全综合征(MODS)与IL4、IL10、IL12、IL13的关系。方法　用ELISA法对33例重伤患者的血浆IL4,IL10,IL12,IL13进行同时测定。结果　所有患者不论是否有SIRS、器官衰竭均未测出IL4;血浆IL10随器官衰竭的数目的增加,水平升高(P<0.05);SIRS组、死亡组、IL10的水平较非SIRS组、存活组明显升高(P<0.01);血浆IL12水平SIRS组较正常和无SIRS组升高(P<0.05)。存活组IL12较死亡组升高;血浆IL13水平在SIRS组、死亡组与非SIRS组、存活组比较无明显差异,但较正常组升高(P<0.05)。结论　创伤后MODS患者的血浆中IL10升高,IL12降低预后不良     

Association between cumulative serum urate and development of diabetes type II: the Kailuan Study

Clinical Rheumatology - To explore whether cumulative serum urate (cumSU) is correlated with diabetes type II mellitus incidence. In this study, we recruited individuals participating in all...     

Metabolic syndrome,high-sensitivity C-reactive protein levels and the risk of new-onset atrial fibrillation: Results from the Kailuan Study

Background and aimsSome studies have reported that metabolic syndrome (MS) and a high inflammatory state are risk factors for atrial fibrillation (AF). However, the combined effect of MS and a high inflammatory state on AF is still unknown. We aimed to investigate the association of MS and high-sensitivity C-reactive protein (hs-CRP) levels with the risk of AF in a large community-based population.Methods and resultsA total of 81,092 subjects from the Kailuan Study with electrocardiogram examination and hs-CRP data at baseline (1st examination, 2006–2007) were included in this study. The enrolled population was divided into 4 groups according to the presence or absence of metabolic syndrome and high hs-CRP (>3 mg/L). The follow-up examinations were performed every two years (2nd examination, 2008–2009; 3rd examination, 2010–2011; 4th examination, 2012–2013; 5th examination, 2014–2015). All participants were followed until the occurrence of AF or the date of the last examination. After a mean time of 7.2 ± 2.0 years, a total of 271 individuals developed incident AF. MS or high hs-CRP alone was not associated with incident AF after multivariable adjustment. However, multiple Cox regression analysis showed that subjects with MS and hs-CRP > 3 mg/L had a greater risk for AF than those without MS and with hs-CRP ≤ 3 mg/L (hazard ratio, 1.61; 95% confidence interval 1.08–2.41; P = 0.019).ConclusionMS combined with a high hs-CRP level is associated with an increased risk for AF in the Chinese population. However, the mechanism is unknown and awaits further study.Trial registration sitehttp://www.chictr.org.cn/index.aspx.Registration numberChiCTR-TNRC-11001489.     

开滦集团健康体检人群中年男性中心性肥胖对心脏结构的影响

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睡眠时间和睡眠质量对中国成年男性高血压患病率的影响

目的探讨不同的睡眠时间和睡眠质量与中国成年男性高血压患病率的关系。方法本研究为横断面研究,于2013年9-12月,共调查唐山矿社区18岁以上男性4 519人。所有人均接受人体学测量、血液学检查和问卷调查。睡眠质量采用标准的匹兹堡睡眠质量问卷进行测量。睡眠时间和睡眠质量对高血压患病率的影响采用多因素logistic回归分析。结果与非高血压人群相比,高血压人群的睡眠时间较短,睡眠质量较差。单纯睡眠时间过短或睡眠质量较差均能显著地提高成年男性人群的高血压患病率(OR=1.33,95%CI:1.13~1.56,P<0.05;OR=1.81,95%CI:1.44~2.29,P<0.05)。但如果考虑睡眠时间和睡眠质量的相互影响,结果显示只有睡眠质量中等合并睡眠时间过短,以及睡眠质量较差合并睡眠时间过短或过长时才能使高血压患病率显著升高(OR=1.92,95%CI:1.65~2.23,P<0.05;OR=2.18,95%CI:1.66~2.86,P<0.05;OR=1.55,95%CI:1.25~1.92,P<0.05)。结论单独睡眠时间不足或睡眠质量差均能显著促进中国成年男性高血压患病率的升高,并且两者具有协同作用。     

糖尿病人群中各型高血压的分布情况及其影响因素研究

目的了解糖尿病人群中各型高血压的分布情况,并探讨其影响因素。方法依据开滦研究(Chi CTR-TNC-11001489)的资料,选取符合本研究纳入及排除标准的6 349例糖尿病患者作为研究对象。描述糖尿病人群中各型高血压的分布情况,采用Logistic回归分析探讨糖尿病患者合并各型高血压的影响因素。结果 (1)糖尿病人群中高血压的患病率为51.2%(3 252/6 349),男性为52.6%(2 798/5 318),女性为44.0%(454/1 031)。糖尿病人群中单纯收缩期高血压(ISH)、单纯舒张期高血压(IDH)及双期高血压(SDH)的患病率分别为12.4%(790/6 349)、8.0%(508/6 349)及30.8%(1 954/6 349)。(2)正常血压组和高血压组患者的性别、平均年龄、体力劳动、吸烟、饮酒、喜咸、体育锻炼、收缩压、舒张压、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、体质指数(BMI)、估计肾小球滤过率(e GFR)及超敏C反应蛋白(hs-CRP)比较,差异均有统计学意义(P<0.05)。Logistic回归分析显示,性别、体力劳动、吸烟、饮酒、平均年龄、FPG、TG、LDL、HDL、BMI及e GFR对糖尿病合并高血压的影响有统计学意义(P<0.05)。(3)ISH组、IDH组及SDH组患者间性别、体力劳动、吸烟、体育锻炼、平均年龄、收缩压、舒张压、TC、TG、HDL、BMI、e GFR及hs-CRP比较,差异有统计学意义(P<0.05),饮酒、喜咸、FPG及LDL比较,差异无统计学意义(P≥0.05)。Logistic回归分析显示,平均年龄、FPG、HDL、BMI及e GFR对糖尿病患者合并ISH的影响有统计学意义(P<0.05);性别、饮酒、喜咸、平均年龄、TC、BMI、e GFR及hs-CRP对糖尿病患者合并IDH的影响有统计学意义(P<0.05);性别、体力劳动、吸烟、饮酒、体育锻炼、平均年龄、FPG、TC、HDL、BMI及e GFR对糖尿病患者合并SDH的影响有统计学意义(P<0.05)。结论糖尿病人群中高血压的患病率较高,糖尿病合并不同类型高血压的影响因素存在差异。     

Total cholesterol,alanine aminotransferase and the risk of primary liver cancer: A population-based prospective study

Previous studies have shown that serum total cholesterol (TC) and serum alanine aminotransferase (ALT) are associated with liver cancer risk. However, the common contribution of TC and normal-high ALT to primary liver cancer (PLC) has not been reported. We aim to assess the separate and joint effect of low TC level and normal-high ALT level on the risk of PLC, a large prospective cohort was conducted in our study.The participants were divided into 4 groups via the cross-matching method according to TC [low level (−)/non-low level (+)] and ALT [normal level (−)/normal-high level(+)] status, and using the lower quartile value of TC and the upper quartile value of ALT as a threshold, respectively. Incident PLC was confirmed by review of medical records. Cox proportional hazards regression models and interactive additive models were used to evaluate whether the joint effect of low TC level and normal-high ALT level is associated with the risk of PLC.During 1,248,895 person-years follow-up, 298 participants were diagnosed with PLC among 114,972 subjects. In male population, TC < 4.24 mmol/L was group “TC (−)”; TC ≥ 4.24 mmol/L was group “TC (+)”; ALT < 23 U/L was group “ALT (−)”: 33 U/L ≥ ALT ≥ 23 U/L was group “ALT (+)”. Compared with the group “TC (+)”, group “ALT (−)”, respectively, the adjusted hazard ratio (HR) and 95% confidence interval (95%CI) for PLC risk was 1.74 (1.36–2.25) in group “TC (−)” and 1.49 (1.15–1.94) in group “ALT (+)”. In combinatorial analysis, compared with group “TC (+) and ALT (−)”, the significant increased risk of PLC were observed in group “TC (+) and ALT (+)” (HR = 1.41; 95% confidence intervals [CI]: 1.02–1.95), group “TC (−) and ALT (−)” (HR = 1.67; 95%CI: 1.24–2.27) and group “TC (−) and ALT (+)” (HR = 2.72; 95%CI: 1.81–4.09), respectively. However, no statistical significance was found among female.The separate and joint effect of low TC level and normal-high ALT level was observed for PLC risk in males. When combined, individuals with coexistence of low TC level and normal-high ALT level significantly increase the risk of PLC.     

唐山地区成人社区获得性肺炎感染革兰阴性菌的危险因素分析

目的分析唐山地区成人社区获得性肺炎(CAP)患者感染革兰阴性菌的危险因素,为早期识别革兰阴性菌CAP和合理用药提供借鉴。方法 2011年10月—2012年9月期间,选取唐山市行政区域内6所医院呼吸内科确诊为CAP的成人住院患者530例,收集患者一般资料、体格检查、辅助检查和病原学资料,依据以上资料计算患者预后研究小组评分(PORT);采集患者痰标本进行致病菌检测。采用单因素Logistic回归和多因素Logistic回归分析CAP患者感染革兰阴性菌的危险因素。结果 530例CAP患者中,172例(32.45%)患者检测出细菌195株,其中革兰阴性菌154株(78.97%),革兰阳性菌41株(21.03%)。单因素Logistic回归分析结果显示,年龄≥65岁、入院前应用抗生素、合并基础疾病、合并脑血管疾病、营养不良、白细胞异常、中性粒细胞<1×10~9/L、PORT≥Ⅲ级、总胆红素>17.1μmol/L和血尿素氮>7.1 mmol/L为CAP患者感染革兰阴性菌的可能危险因素。多因素Logistic回归分析结果显示,入院前应用抗生素(OR=2.327,95%CI为1.453~3.725),白细胞异常(OR=2.904,95%CI为1.879~4.490),PORT≥Ⅲ级(OR=3.839,95%CI为2.427~6.071),血尿素氮>7.1 mmol/L(OR=4.133,95%CI为2.585~6.606)为革兰阴性菌CAP的独立危险因素。结论入院前应用抗生素、白细胞异常、PORT≥Ⅲ级、血尿素氮>7.1 mmol/L的CAP患者易感染革兰阴性菌,临床经验性抗感染治疗应考虑以上危险因素。     

河北某煤矿工人累积接尘量与尘肺发病危险性的剂量-反应关系

[目的]通过对河北唐山某煤业集团唐山地区所属煤矿接尘工人的队列研究,分析煤工尘肺发病特征,研究接尘工人累积接尘量与尘肺发病危险性的剂量-反应关系。[方法]以该集团1970—2010年开始接尘工人为研究对象,按照研究内容收集资料,通过寿命表的方法对累积接尘量与累计发病率进行分析。煤工尘肺患者发病年龄、接尘工龄、潜伏期等采用单因素方差分析;发病率差异采用χ2检验,累计发病率之间差异采用Log-Rank检验。[结果]符合纳入标准接尘工人共17 023人,其中煤工尘肺患者838人,发病率为4.92%。掘进工尘肺发病率最高(17.91%),其次为混合工(11.35%),以下为采煤工(8.74%)和辅助工(0.81%),4个工种尘肺发病率差异有统计学意义(χ2=1168.08,P<0.001)。按累积接尘量分段,掘进工在1 700 mg/(m3·年)~组段的累计发病率为49.79%;采煤工在1 800 mg/(m3·年)及以上组段的累计发病率为35.92%;混合工在1 800 mg/(m3·年)及以上组段的累计发病率为38.01%;辅助工在16 mg/(m3·年)及以上组段的累计发病率为3.69%。[结论]不同工种的累计发病率均随着累积接尘量的增加逐渐增高。在一定累积接尘量区间内,累计发病率快速增长,此累积接尘量区间下的限值为:掘进工900 mg/(m3·年),采煤工1 200 mg/(m3·年),混合工1 000 mg/(m3·年),有参考意义。     

后循环短暂性脑缺血发作患者数字减影脑血管造影评价

目的 利用数字减影脑血管造影（DSA）方法观察后循环短暂性脑缺血发作患者脑血管的结构异常情况,探讨其临床价值.方法 对136例后循环短暂性脑缺血发作的患者进行DSA检查,分析其临床资料及血管学资料.结果 在所有患者中,脑血管造影发现血管病变88例,在没有明确的血管病变的48例患者中,椎动脉发育不良16例,单纯胚胎型大脑后动脉10例.结论 后循环短暂性脑缺血发作患者中脑血管造影检查阳性率高,提示在动脉粥样硬化基础上,脑血管狭窄特别是椎基底动脉系统血管狭窄为其重要病因;在无明确血管狭窄的患者中,椎动脉发育不良、胚胎型大脑后动脉可能是后循环短暂性脑缺血发作的重要病理、生理基础.