全文获取类型
收费全文 | 10380篇 |
免费 | 814篇 |
国内免费 | 548篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 55篇 |
妇产科学 | 220篇 |
基础医学 | 993篇 |
口腔科学 | 143篇 |
临床医学 | 1396篇 |
内科学 | 1279篇 |
皮肤病学 | 114篇 |
神经病学 | 320篇 |
特种医学 | 662篇 |
外国民族医学 | 8篇 |
外科学 | 1272篇 |
综合类 | 3444篇 |
现状与发展 | 2篇 |
预防医学 | 463篇 |
眼科学 | 84篇 |
药学 | 391篇 |
3篇 | |
中国医学 | 166篇 |
肿瘤学 | 652篇 |
出版年
2024年 | 11篇 |
2023年 | 191篇 |
2022年 | 291篇 |
2021年 | 378篇 |
2020年 | 314篇 |
2019年 | 202篇 |
2018年 | 203篇 |
2017年 | 231篇 |
2016年 | 227篇 |
2015年 | 377篇 |
2014年 | 498篇 |
2013年 | 638篇 |
2012年 | 938篇 |
2011年 | 1002篇 |
2010年 | 699篇 |
2009年 | 584篇 |
2008年 | 529篇 |
2007年 | 634篇 |
2006年 | 464篇 |
2005年 | 410篇 |
2004年 | 569篇 |
2003年 | 601篇 |
2002年 | 611篇 |
2001年 | 241篇 |
2000年 | 221篇 |
1999年 | 183篇 |
1998年 | 112篇 |
1997年 | 106篇 |
1996年 | 46篇 |
1995年 | 38篇 |
1994年 | 37篇 |
1993年 | 35篇 |
1992年 | 32篇 |
1991年 | 30篇 |
1990年 | 34篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 3篇 |
1986年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
慢性放射性溃疡32例治疗体会 总被引:6,自引:0,他引:6
慢性放射性溃疡治疗难度较大,为寻求适当的治疗方案提高疗效,对既往病例进行了回顾。总结了自1983年以来,慢性放射性溃疡32例的治疗经验,对发病原因、部位、病变特点及治疗方法作了分析。31例治愈、创面I期愈合26例,Ⅱ期愈合5例,死亡1例。认为须提高对放射溃疡的重视和认识,针对不同的病变部位,深度及其特点,采取不同的清创方法及相应的修复措施。为改善局部血循环,应以皮瓣或肌皮瓣治疗为首选。 相似文献
42.
为探讨医院内细菌感染的流行病学特点,作者借助临床分离的64株肺为克雷伯菌,45株阴沟肠杆菌和63株醋酸钙不动杆菌,进行质粒图谱分3种细菌分别有58株,35株和41株含有质粒,且分别构成46个,21个和23个质粒图谱型。结果表明:质粒分析为查明医院内细菌感染源和感染途径提供了较为直接,准确的客观依据,同时也看到了质粒分析的局限性。 相似文献
43.
本文介绍一种使继发性唇裂鼻畸形获得较好外形的新手术方法。术式包括切除偏曲的鼻中隔软骨,并将一片硅胶植入于中央作为鼻小柱支柱,从而矫正歪斜的鼻小柱和抬高鼻尖,使两侧鼻孔形态对称一致,用本法为11例单侧唇裂畸形较重者进行了整复,随访4个月至4年半。绝大多数(10/11)取得满意效果,未见有严重感染和变形等并发症。 相似文献
44.
人外周血CD68^+单核细胞体外的分选及诱导分化为破骨细胞 总被引:7,自引:0,他引:7
OBJECTIVE: To establish a method for obtaining highly purified primary human osteoclast precursors for the biochemical and molecular biological research. METHODS: CD68(+) mono/macrophages were separated from peripheral blood mononuclear cells (PBMCs) of healthy donors by means of immunomagnetic cell sorting for subsequent analysis with flow cytometry. The isolated cells were incubated on coverslips or bone slices in the presence of dexamethasone(10(-8) mol/L), macrophage colony-stimulating factor (25 microg/L ) and soluble receptor activator of nuclear factor (NF)-kappaB ligand (s-RANKL, 16 microg/L). Calcitonin receptor (CR) immunocytochemistry and tartrate-resistant acid phosphatase (TRAP) histochemistry were employed. The bone slices were also studied by scanning electron microscopy (SEM). RESULTS: Fluorescence-activated cytometric analysis showed that 93.06%+/-0.61% n=4 of the selected cells were CD68(+) cells. After 7 days of culture of the CD68(+) cells, VR+, TRAP+ multinucleated giant cells appeared, and resorption lacunae could be observed by SEM. CONCLUSION: Highly purified CD68(+) cells can be obtained from human PBMCs as the osteoclast precursors, and mature osteoclasts can be induced from CD68(+) mono/macrophages by RANKL. 相似文献
45.
骨与关节损伤治疗中存在的问题与对策 总被引:5,自引:0,他引:5
尽管骨关节损伤治疗已取得巨大进展,但仍存在许多问题,主要包括:对骨折治疗理念转变和微创外科概念的错误理解,对骨折治疗技术的不正确使用,忽视骨折分类方法和功能评定标准.正确的分析和解决这些问题会进一步促进创伤骨科临床实践和科研的进步. 相似文献
46.
OBJECTIVE: To investigate the factors responsible for Pseudomonas aeruginosa nosocomial cross-infection in the intensive care unit (ICU) and provide effective measure for the prevention and management. METHODS: The homology of 7 Pseudomonas aeruginosa strains isolated from the patients in the ICU and the environment was examined by biological, serological, drug-resistance and plasmid analysis. RESULTS: The results of serological and plasmid analyses had good consistency, which demonstrated that the 7 Pseudomonas aeruginosa strains originated from solution in the oxygen humidifier, with uniform serological and plasmid type, and belonged to the same clone with cross-infection by contact between the patients or nursing staff and the objects in the ICU. CONCLUSION: Serological and plasmid analyses are more practical for identifying the sources of Pseudomonas aeruginosa cross-infection, which can be prevented by strict disinfection of the instrument and supervision of the nursing staff in the ICU. 相似文献
47.
伤害控制骨科学--多发伤治疗最新观点 总被引:12,自引:3,他引:9
挽救生命、减少伤残仍是多发伤救治的基本观点,治疗的形式和时机却在逐渐地变化、修正,伤害控制原则是一项新的多发伤治疗策略,其在创伤骨科的应用产生了伤害控制骨科学。伤害控制骨科学包括三步,第一步:早期临时固定不稳定性骨折、止血,如果需要,作颅内减压;第二步:在ICU内复苏病人使其各项生理指标达到理想状态;第三步:病人病情稳定后进行最终的正式手术固定骨折。伤害控制骨科学适应证:血液动力学不稳定及极度危重的多发伤病人应遵循伤害控制原则;对临界病人,仍可早期手术正式固定骨折,但如果手术过程中任何时间发生病情恶化,手术应该立即改为伤害控制。伤害控制骨科学是一项正在发展、完善的技术,将来研究需要进一步验证既有观点的有效性,以减少多发伤病人ARDS和MOF的发生。 相似文献
48.
生物型人工硬脑膜应用的实验研究 总被引:9,自引:0,他引:9
OBJECTIVE: To evaluate the safety and efficacy of a dural graft prepared using porcine membrane in duraplasty. METHODS: Eighteen New Zealand rabbits were randomly divided into groups A (n=4), B (n=4), C (n=5), and D (n=5) sacrificed 3, 14, 30 and 90 d after duraplasty, respectively. Each animal underwent bilateral parietal craniectomy behind the coronal suture and beside the midline to expose the dura, which was cut on the right side and substituted with the dural graft. The exposed dura on the left was kept intact as control. The rabbits were observed for WBC counts before the operation and before sacrifice by transcardiac formalin perfusion, respectively. The meninges and brain tissues were histologically examined after sacrifice. RESULTS: The WBC count varied little after the operation (P>0.05). Microscopic examination demonstrated tissue repair on both the implantation side and control side, without graft adhesion to the cortical surface. In group A, a large number of leukocytes were seen gathering on the lateral dura, suggesting acute tissue repair. In group B, endothelial cells covering the inner surface of the graft could be seen. Fibroblasts and fibrocytes were seen in the grafts between collagen fibers in group C, and in group D, fibroblasts and fibrocytes increased between the collagen fibers and the suture healed. CONCLUSION: The dura graft is safe and applicable for dural defect repair. 相似文献
49.
丙型肝炎病毒感染对肾移植术后影响的临床研究 总被引:3,自引:0,他引:3
Li-xin Yu Zhi-peng Wang Shao-jie Fu Yi-bin Wang Chu-fu Du Jian Xu Wen-feng Deng 《第一军医大学学报》2004,24(6):682-684
OBJECTIVE: To study the influence of hepatitis C virus (HCV) infection on the clinical outcome of kidney transplantation. METHODS: The recipient/graft survival, the incidence of acute/chronic rejection and cause of death in 86 HCV-infected recipients of renal transplantation were compared with those in another 86 recipients without HCV infection. RESULTS: HCV-infected recipients had significantly shorter 5-year survival (74.4%) than those without HCV infection (87.2%, P<0.01). The 1-year (94.2%/90.7% vs 96.8%/96.0%) and 3-year recipient/graft survival rates (88.4%/79.1% vs 90.7%/87.2%), the incidence of acute/chronic rejection (31.3% vs 21.2%, and 12.5% vs 6.5%) and the 5-year graft survival (73.3%/81.4%) were comparable between the two groups (P>0.05). Hepatic disease was identified as the primary cause of mortality. CONCLUSIONS: HCV infection may affect the long-term survival of the recipients with kidney transplantation, and therefore should be considered as a relative contraindication of kidney transplantation. 相似文献
50.
效应室浓度作为目标浓度靶控输注异丙酚的脑摄取研究 总被引:9,自引:0,他引:9
OBJECTIVE: To study the correlation between the effect compartment concentration (ECC) and the brain uptake of propofol during sedation by target-controlled infusion (TCI). METHOD: Twelve ASA physical status I to II patients with neither cardiac nor intracranial diseases were scheduled for elective abdominal operation. Computer-assisted target-controlled infusion of propofol was performed for general anesthesia in all patients with the target ECC set at 4.0 microgram/ml. The plasma propofol concentrations were measured simultaneously from the radial artery and the jugular bulb at different time points by high performance liquid chromatography (HPLC), and the area under time-concentration curve (AUC(a-jv)) was calculated. RESULT: Before reaching the target propofol concentration of 4.0 microgram/ml (4.7+/-0.16 min), EEC was positively correlated with AUC(a-jv) (r(ECC-AUC)=0.977, P<0.001), but neither the arterial (Ca) nor jugular bulb propofol concentrations (Cjbv) showed such relation to AUC(a-jv) (r(Ca-AUC)= 0.054, P=0.92; r(Cjbv-AUC)=0.335, P=0.516). When ECC was controlled at 4.00 microgram/ml by TCI, Ca was comparable with Cjbv (P=0.512). Positive correlation was noted between AUCa-jv and ECC (r(ECC-AUC)=0.942, P<0.005) after the termination of infusion till the consciousness recovery of the patients, and Ca and Cjbv showed similar correlation with AUC(a-jv) (r(Ca-AUC)=0.986, P<0.001; r(Cjbv-AUC)=0.974, P<0.001). CONCLUSION: During TCI of propofol with ECC as the target concentration, ECC is significantly correlated with AUC(a-jv) to reflect the dynamic changes in cerebral propofol uptake. 相似文献