脱落金属托槽底板处理方法的研究现状

目的 正畸托槽是固定矫治中不可或缺的部件,因其使用时间长,易脱落等特点,而使用新托槽又增 加患者经济负担,故其回收再利用的方法一直受到人们广泛关注。目前,常用的托槽回收方法较多,均存 在一定优点与不足,本文对脱落金属托槽底板处理方法及具体操作方式作一综述,旨在探讨各方法的优缺 点以及研究进展,以期为临床脱落托槽的再利用提供参考意义。     

基于生物信息学手段筛选对肾透明细胞癌具有潜在干预作用的天然活性成分及中草药

目的 应用生物信息学及系统药理学的方法探索可干预肾透明细胞癌的潜在化学成分以及含有目的成分的中草药。方法 首先借助ＧＥＯ基因表达谱数据分析筛选得到肾透明细胞癌与癌旁正常组织的差异基因,同时分析得到差异基因的生物学功能,接着构建差异基因的蛋白互作网络,进一步分析差异基因的在TCGA及GTEx背景数据库中的表达及预后价值,得到目标基因后借助CTD数据库挖掘与目标基因相关化合物,剔除非天然化合物后经TCMSP工具寻找含有天然化合物的中草药。结果 得到肾透明细胞癌与癌旁正常组织的差异基因共有357个上调基因,353个下调基因,富集生物过程包括氧化还原过程、排泄、对药物的反应等,分子功能包括蛋白质均二聚活性、运输活动、受体结合等,细胞定位在细胞外泌体、质膜的组成部分、顶质膜等。在KEGG信号中富集到PPAR信号通路、碳代谢、甘氨酸,丝氨酸和苏氨酸的代谢等信号通路,利用cytohuba基于degree筛选排名前20的基因为核心基因,有明确差异以及有预后意义的BUB1、C3、KIF20A、RRM2、TOP2A基因确定为目标探究与其相关的化合物72个,包含每种化合物的中草药至少一种。结论 基于生物信息学挖掘到多种中草药可以影响目标基因从而干预肾透明细胞癌。     

慢性肾功能衰竭血尿酸水平与急性ST段抬高心肌梗死患者预后关系研究

目的研究慢性肾衰竭血尿酸水平与急性ST段抬高心肌梗死患者预后的关系。方法选择慢性肾衰竭合并高尿酸血症患者作为观察组、慢性肾衰竭未合并高尿酸血症患者作为阴性对照组、肾功能正常的高尿酸血症患者作为阳性对照组,观察发生心肌梗死的例数、检测心功能相关指标、评估负面情绪,并对心肌梗死发生的相关因素进行logistic回归分析。结果慢性肾衰竭不同分期均存在高尿酸血症,其表达水平明显高于肾功能正常组;心肌梗死的发生与高尿酸血症、贫血、营养不良、高血压、异位钙化、抑郁情绪呈正相关。观察组左心室舒张末期直径、射血分数明显低于对照组,发生心肌梗死的例数、ST段抬高程度、HAMD评分、HAMA评分、VAS评分均明显高于对照组。结论高尿酸血症是慢性肾衰竭诱发心肌梗死的危险因素,会对心功能造成不同程度的损害。     

Chromosomal instability in rodents caused by pollution from Baikonur cosmodrome

An assessment of the health status of ecosystems exposed to man-made pollution is a vital issue for many countries. Particularly it concerns the consequences of contamination caused by the activity of the space industry. Each rocket launch is accompanied by the introduction of parts of the rocket propellant into the environment. This study aims to scrutinize the effect of the components of rocket fuel on the induction of lipid peroxidation and chromosomal aberrations on rodents inhabiting the area exposed to pollution from Baikonur cosmodrome. The results showed the increase of the level of lipid hydroperoxide and malondialdehyde in the livers of Citellus pygmaeus Pallas and Mus musculus L., which indicates an augmentation of free radical activity and DNA damage. The cytogenetic analysis of bone marrow cells revealed that the frequency of chromosomal aberrations was a few times higher in the rodents from contaminated territory. The signs of oxidative stress and high level of chromosomal aberrations indicate the environmental impact of the cosmodrome, and its possible toxic and mutagenic effects on ecosystems.     

Maintaining physical exercise as a matter of synchronising practices: Experiences and observations from training in Mixed Martial Arts

This paper is concerned with the establishment, maintenance, and decline of physical exercise practices. Drawing on experiences and observations taken from a carnal ethnography and rhythmanalysis of the practices involved in training in Mixed Martial Arts (MMA), I argue that maintaining this physical exercise practice is not straightforwardly an outcome of individual commitment, access to facilities, or the availability of free time. It rather depends on the synchronisation of practices: those of MMA, those that support MMA, and those that more broadly make up everyday life. This research suggests that increasing rates of physical activity might be better fostered through facilitating the integration of combinations of healthy activities into everyday life.     

Statistical and Reliability Study on Shear Strength of Recycled Coarse Aggregate Reinforced Concrete Beams

The consumption of structural concrete in the construction industry is rapidly growing, and concrete will remain the main construction material for increasing urbanization all over the world in the near future. Meanwhile, construction and demolition waste from concrete structures is also leading to a significant environmental problem. Therefore, a proper sustainable solution is needed to address this environmental concern. One of the solutions can be using recycled coarse aggregates (RCA) in reinforced concrete (RC) structures. Extensive research has been conducted in this area in recent years. However, the usage of RCA concrete in the industry is still limited due to the absence of structural regulations appropriate to the RCA concrete. This study addresses a safety margin of RCA concrete beams in terms of shear capacity which is comparable to natural coarse aggregates (NCA) concrete beams. To this end, a database for reinforced concrete beams made of recycled coarse aggregates with and without shear reinforcement was established, collecting the shear specimens available from various works in the existing literature. The database was used to statistically identify the strength margin between RCA and NCA concrete beams and to calculate its safety margin based on reliability analysis. Moreover, a comparability study of RCA beams was conducted with its control specimens and with a database for conventional RC beams.     

Genome-wide identification of the Penicillium digitatum bZIP gene family and the roles of one key member,PdatfA

Penicillium digitatum is the most common cause of postharvest decay in citrus fruits around the world. Previous studies revealed that the bZIP gene family plays crucial roles in development, stress adaptation, and pathogenicity in fungi. However, little is known about the bZIP genes in P. digitatum. In this study, we systematically identified the bZIP family in 23 Penicillium species and analyzed their evolutionary relationships. We found that gene loss and gene duplication shaped the evolution of the Penicillium bZIP family. P. digitatum experienced 3 bZIP gene loss events, but with no gene duplication. We subsequently characterized the biological functions of one important member, PdatfA in P. digitatum by constructing the deletion mutant. Results showed that ΔPdatfA exhibited a moderate growth defect, reduced pigmentation, and slightly increased resistance to fungicides iprodione and fludioxonil. However, ΔPdatfA displayed similar rot symptoms to that of the wild-type. The ΔPdatfA mycelia were not affected in response to oxidative stress while its conidia showed enhanced resistance due to the upregulation of catalases. Our results provide new insights into the evolution and functions of the bZIP gene family in Penicillium.     

Can mental healthcare for Muslim patients be person-centred without consideration of religious identity? A concurrent analysis

BackgroundMuslims constitute the largest, fastest growing religious minority in the UK. Globally, nurses are legally, morally and ethically obliged to provide non-discriminatory, person-centred, culturally sensitive care. This obligation includes supporting people with their religious needs where appropriate, but there is evidence this is not always happening, particularly for Muslims in mental health care.AimsThis paper reviewed primary research to address the question: Can mental healthcare for Muslims be person-centred without consideration of religious identity?MethodsNarrative synthesis and concurrent analysis. Searches were conducted post 2000 in MEDLINE, CINAHL, SAGE, PsychINFO and ASA with terms: ‘Muslim’, ‘Islam* ’, ‘mental health’, ‘nurs* ’, ‘person-cent* ’, ‘religio* ’. Narrative data were analysed for commonalities and themes.FindingsSeven studies of sufficient quality were analysed. Unconscious religious bias was the overarching theme linking the findings that healthcare staff felt ill-prepared and lacked necessary knowledge and experience to work with diverse patient groups. Unconscious racial bias contributed to limited cultural/ religious competence in treatment and care.ConclusionReligious identity is core for Muslim patients, so this group may not be receiving the person-centred care they deserve. Nurses need cultural and religious competence to deliver person-centred, holistic care to diverse patient populations, yet the importance of religious practice can be overlooked by staff, with harmful consequences for patient’s mental and spiritual welfare. This paper introduces a welcome pack that could help staff support the religious observance of those Muslim patients/service-users wishing to practice their faith during their stay in health services.