白介素-6、血管内皮生长因子、D-二聚体对CSDH的影响

目的探讨血肿局部炎症、假膜新血管生成、局部纤溶状况及其在CSDH发生、发展中的作用。进而探讨CSDH的发病机制，并为CSDH的治疗及预防复发提供理论依据。方法以78例CSDH患者作为病例组，20例健康人作为正常对照组。采用ELISA法测定患者血清及血肿液中VEGF及IL-6的含量。比较患者末梢静脉血及血肿液中四种因子的含量变化并与正常对照组比较。结果病例组血肿液FDP、d-dimer检测均为阳性，血液为阴性；正常对照组血液FDP、d-dimer检测均为阴性；病例组血清VEGF含量与正常对照组比较差异无统计学意义。血肿液中VEGF浓度高于血清中。病例组血清IL-6浓度与正常对照组差异无统计学意义，血肿液中IL-6浓度高于血清中。CSDH患者血肿液VEGF、IL-6水平没有相关性。结论CSDH患者血肿液局部纤溶亢进，局部VEGF分泌旺盛，新血管生成活跃，局部炎症活跃，可导致CSDH不断扩大而参与CSDH发病机制。抗炎治疗、抑制VEGF的生理作用、有选择的对病人施行促凝治疗，可成为部分CSDH病人保守治疗及预防复发的有效手段。     

Treatment of Meniere＇s Disease with A Heavy Dosage of Gu Sui Bu （Rhizoma Drynariae）

In treating Meniere＇s disease, author has found that the compatible use of heavy dosage of Gu Sui Bu （骨碎补 Rhizoma Drynariae） can produce very good effect for relieving dizziness, vertigo and tinnitus. Some of the sample cases are cited in the following.     

免疫透射比浊法测定血清免疫球蛋白

本文报道免疫透射比浊法测定血清免疫球蛋白,批内CV小于2.0％,批间CV小于3.5％,表明该法简便,快速,精密度和准确度高,重复性好。     

Anticoagulation therapy for pulmonary embolism involving a myxoma mimicking,giant type C thrombus: A case report

Right heart thrombus (RHTh) with concurrent acute pulmonary embolism (PE) is rare and can seriously destabilize hemodynamics, leading to an emergency situation with high mortality. Diagnosis and treatment of RHTh with acute PE are not yet standardized. There are few reports of acute PE concurrent with RHTh and even less is known about patients with a right heart mural thrombus. For physicians, the diagnostic choice and treatment of these patients are particularly difficult due to the lack of knowledge. Here, we report a rare case of partial mural RHTh (type C RHTh) with acute PE. The mural mass in the right heart was initially diagnosed as atrial myxoma according to transthoracic echocardiography (TTE), and both pulmonary embolus and the mural mass were completely absorbed after administering Rivaroxiban. This case suggests that TTE alone is insufficient to identify and diagnoses a right heart mural mass such as this. However, novel oral anticoagulants may be effective at alleviating PE with type C RHTh.     

HPLC测定心可宁胶囊中原儿茶醛的含量

目的　采用高效液相色谱法测定心可宁胶囊中原儿茶醛的含量。方法　InertsilC1 8柱 (5 μm ,1 5 0mm× 4 .6mm) ;流动相为甲醇 - 0 .0 5mol·L-1 磷酸二氢钾缓冲液 (磷酸调pH 3.0 ) (2 0∶80 ) ;检测波长为 2 80nm。结果　原儿茶醛进样量在 0 .0 5 5 3～2 .2 1 30 μg范围内线性关系良好 (r=0 .9999) ;平均加样回收率为 99.7% (n =9) ;方法精密度RSD =0 .5 0 % (n =6 )。 结论　本方法操作简便、准确、重复性好 ,可作为该制剂中原儿茶醛的含量测定方法     

国家药品标准中值得注意的几个问题

<药品管理法>第三十二条规定:药品必须符合国家药品标准.中华人民共和国药典、国家药品监督管理局颁发的药品标准、以及仍在使用的卫生部颁布的药品标准都是国家药品标准.国家药品监督管理局规定,局颁标准从2002年12月1日起生效,同品种地方标准、包装、标签和说明书同时停止使用.但是我们在具体工作时,遇到了同品种药品不仅出现在地方标准,而且还在三个国家标准中出现,此外还发现局颁标准的编印质量不高.这就对标准的可操作性、严肃性构成了威胁,现分述如下,以期引起有关部门的注意.     

德阳市颅脑交通伤流行病学分析

目的:以德阳市为样本,研究颅脑交通伤的流行病学特征.方法:回顾性分析德阳地区5县市1区2000～2005年道路交通伤害的资料.结果: 颅脑交通伤中以男性居多;高危年龄段为30～40岁;第四季度为高峰期;1d内高峰时间多在中午和下午,0～1时形成一次明显的高峰.结论:降低颅脑交通伤害事故,需要综合治理,遵循其特有的规律,完善救护体系.     

产妇先兆性流产的发生与妊娠生殖道感染的相关性

【摘要】目的 探讨产妇在妊娠期出现生殖道感染与发生先兆性流产之间的关系。方法 选取2015年7月～2016年7月我院收治的62例早期先兆流产产妇设为观察组,选取同期在我院接受分娩的正常孕妇60例为对照组,行回顾性分析。对两组产妇进行白带常规镜检、解脲支原体(UU)以及沙眼衣原体(CT)阳性率检测。结果 观察组白带常规白细胞百分率、清洁度百分率、念珠菌阳性率与对照组比较差异均有统计学意义(P＜0.05),两组乳酸杆菌阳性率之间的差异无统计学意义(P＞0.05);观察组患者感染UU、CT总百分比与对照组比较明显较高,差异有统计学意义(P＜0.05);观察组患者炎症因子水平IL 1、TNF α和IL 8明显高于对照组(P＜0.05)。结论 先兆性流产产妇的白带异常率、解脲支原体阳性率、沙眼衣原体阳性率和炎症因子水平均明显高于正常产妇,可能是先兆性流产发生的重要原因之一。因此应注意加强产前检查,控制产妇孕激素水平,采取积极有效的方法治疗生殖道感染,改善不良妊娠结局。     

The TopClosure? 3S System, for skin stretching and a secure wound closure

The principle of stretching wound margins for primary wound closure is commonly practiced and used for various skin defects, leading at times to excessive tension and complications during wound closure. Different surgical techniques, skin stretching devices and tissue expanders have been utilized to address this issue. Previously designed skin stretching devices resulted in considerable morbidity. They were invasive by nature and associated with relatively high localized tissue pressure, frequently leading to necrosis, damage and tearing of skin at the wound margins. To assess the clinical effectiveness and performance and, to determine the safety of TopClosure? for gradual, controlled, temporary, noninvasive and invasive applications for skin stretching and secure wound closing, the TopClosure? device was applied to 20 patients for preoperative skin lesion removal and to secure closure of a variety of wound sizes. TopClosure? was reinforced with adhesives, staples and/or surgical sutures, depending on the circumstances of the wound and the surgeon's judgment. TopClosure? was used prior to, during and/or after surgery to reduce tension across wound edges. No significant complications or adverse events were associated with its use. TopClosure? was effectively used for preoperative skin expansion in preparation for dermal resection (e.g., congenital nevi). It aided closure of large wounds involving significant loss of skin and soft tissue by mobilizing skin and subcutaneous tissue, thus avoiding the need for skin grafts or flaps. Following surgery, it was used to secure closure of wounds under tension, thus improving wound aesthetics. A sample case study will be presented. We designed TopClosure?, an innovative device, to modify the currently practiced concept of wound closure by applying minimal stress to the skin, away from damaged wound edges, with flexible force vectors and versatile methods of attachment to the skin, in a noninvasive or invasive manner.