11例早期胃癌的胃镜与病理分析

目的:分析早期胃癌的胃镜及病理特点,以提高早期胃癌的诊断率。方法:总结我院自2000年至2005年经病理检查证实的11例早期胃癌患者的临床资料。结果:11例早期胃癌患者术前胃镜均确诊为胃癌,胃中分布以胃窦最多6例(54.5%),病理检查示管状腺癌4例、中分化型腺癌1例、低分化型腺癌2例、未分化型腺癌1例、黏液细胞癌2例、印戒细胞癌1例,病灶周围组织为慢性萎缩性胃窦炎9例,肠上皮化生5例,异型增生5例,幽门螺旋杆菌阳性8例,伴胃息肉4例。结论:胃镜是当今诊断早期胃癌最重要、最直接的方法。早期胃癌以Ⅱc型病变多见,胃窦为好发部位,与癌前病变及幽门螺旋杆菌感染密切相关。     

塞来昔布对人鼻咽癌CNE-2细胞生长抑制及放射增敏研究

Objective To investigate the growth inhibition and radiosensitization of Celecoxib in hu-man nasopharyngeal carcinoma cell line CNE-2. Methods CNE-2 growth inhibition by Celecoxib was eval-uated by MTT method. Apoptosis-related changes in morphology were observed by transmission electron mi-croscopy (TEM). Cell cycle distribution and apoptosis rate were measured by flowcytometry (FCM). The ex-pression of COX-2 protein was observed by SP method after the treatment of Celecoxib. Cells were randomly planted into four groups: irradiation control(Ci), drug group(Cd), irradiation group(R), and Celecoxib plus irradiation group(D+R). Single irradiation of 2,4,6,8,and 10 Gy were administered for colonogenic assay. Cell cycle distribution and apoptosis rate were analyzed at 6 Gy irradiation. Results The growth of CNE-2 cell was inhibited by celecoxib in a dose-and time-dependent manner, the IC50 was 80 μmol/L After the treatment, cell ratio of GO and G, phases was increased (47.03±2.76 vs 56.17±1.95, t=4.68, P= 0.010), whereas the ratio of S and G2/M phases was decreased (33.07±1.86 vs 24.87±1.76, t=5.54, P = 0.010; 19.30±0.53: 17.73±0.83, t=2.75, P=0.050), and the apoptosis rate was increased (1.57±0.47:10.47±0.31, t = 27.39, P = 0.000) in a dose-dependent manner. Apoptosis with nuclear chromatin condensation, fragmentation and cell shrinkage was found by TEM. SP method showed that Celeib decreased COX-2 expression (17.48±0.34 vs 12.82±0.51,t=13.20,P =0.00). The sensitivity ratio(D0) was 1.15. FCM showed that the percentage of cells in G2/M phase was significanty more in R and D+R groups than in Ci and Cd groups (68.00±1.65,54.27±5.74,17.60±0.80,14.86±1.23, t=47.70,P=0.000; t=11.63, P=0.000), and also significantly different between R group and D + R group (t=3.99, P= 0.020). The apoptosis rate was higher in R and D + R groups than Ci and Cd groups(4.83±0.97,9.50± 1.35,1.33±0.86 and 2.28±0.42,t=4.67,P=0.010;t=8.81, P=0.000), D + R group than R group(t =4.85,P=0.010). Conclusions Celecoxib can markedly inhibit the growth and induce apoptosis in CNE-2 cells,which may depend on COX-2 pathway. Celeeoxib potently enhances the radiosensitivity of CNE-2 cells,which may due to the repair inhibit of radiation-induced DNA damage, inhibit of cell proliferation,and enhancement of cell apoptosis after irradiation.     

针灸按摩治疗慢性疲劳综合征疗效观察

目的:观察针灸按摩治疗慢性疲劳综合征的疗效.方法:将慢性疲劳综合征患者64例按照就诊顺序随机分为两组,针刺按摩组33例,以针刺按摩方法治疗,对照组31例采用针刺方法治疗.结果:针刺按摩组显效17例;有效15例;无效1例;总有效率96.97%.对照组用常规针刺疗法总有效率为77.42%.两组比较,总有效率具显著性差异(P＜0.05).结论:针刺配合按摩疗法比单纯针刺的临床疗效显著.     

优化流程在门诊输注化疗药物中的应用

目的探讨优化流程在门诊化疗药物输注中应用的效果分析。方法取2008-10-2009-10 268例化疗药使用者为对象,120例为观察组,148例为对照组,通过控制输液流程和优化配药环节,观察静脉穿刺时患者疼痛感觉、输液中渗漏次数、患者对操作满意度进行统计学分析。结果对两组数据进行卡方检验,χ2=63.57,P值<0.01,差异有统计学意义。结论对化疗药输注流程进行优化,可以减轻患者穿刺时疼痛感觉,减少渗漏次数,提高患者满意度。     

可固定调节式医用腹部外敷芒硝袋的制作

目前,医院用于治疗重症胰腺炎患者的腹部外敷芒硝袋是一边开口的长方形口袋,使用时将芒硝装入其中,然后用针线封口,置于患者的腹部.但这种芒硝袋存在多种缺陷:芒硝容易滑向袋子的一端,无法均匀贴服于患者腹部;芒硝更换不方便:因没有固定装置,病人进行翻身等移动时,芒硝袋很容易滑脱,不能持续腹部外敷,因而影响治疗效果.为此,笔者经反复尝试,制作了一种实用新型的可固定调节式医用腹部外敷芒硝袋,获得良好效果.     

孕期健康教育对分娩方式影响的研究

目的：探讨孕期健康教育的有效性和规范性,以及对孕妇分娩方式选择的影响。方法：选择我院2011年和2012年住院分娩的孕产妇临床资料各400例,分为对照组和观察组,两组病例基本情况比较差异没有统计学意义（P〉0.05）。对照组采用常规的产前检查,观察组在常规产前检查的基础上加强孕期健康教育及指导。同时发放调查表,了解分析孕妇及其家属对分娩方式的意向,针对孕妇及其家属关心的问题开展咨询服务。追踪观察最终分娩方式。结果：经重点开展孕期健康教育及指导,对两组孕妇的分娩方式、满意度和舒适度进行比较,观察组的剖宫产率明显低于对照组,两组数据对比具有显著的差异性（P〈0.01）,观察组的满意度和舒适度高于对照组。结论：孕期健康教育及指导很重要。孕期健康教育模式的纳入,不仅可以降低剖宫产率,还可以提高孕产妇及其家属的满意度和舒适度,值得临床推广。