全文获取类型
收费全文 | 4215篇 |
免费 | 283篇 |
国内免费 | 71篇 |
专业分类
耳鼻咽喉 | 50篇 |
儿科学 | 10篇 |
妇产科学 | 66篇 |
基础医学 | 309篇 |
口腔科学 | 58篇 |
临床医学 | 336篇 |
内科学 | 322篇 |
皮肤病学 | 21篇 |
神经病学 | 74篇 |
特种医学 | 253篇 |
外国民族医学 | 13篇 |
外科学 | 365篇 |
综合类 | 265篇 |
预防医学 | 165篇 |
眼科学 | 31篇 |
药学 | 175篇 |
1篇 | |
中国医学 | 17篇 |
肿瘤学 | 2038篇 |
出版年
2024年 | 12篇 |
2023年 | 227篇 |
2022年 | 274篇 |
2021年 | 258篇 |
2020年 | 280篇 |
2019年 | 193篇 |
2018年 | 102篇 |
2017年 | 126篇 |
2016年 | 161篇 |
2015年 | 207篇 |
2014年 | 312篇 |
2013年 | 248篇 |
2012年 | 275篇 |
2011年 | 275篇 |
2010年 | 218篇 |
2009年 | 245篇 |
2008年 | 111篇 |
2007年 | 230篇 |
2006年 | 208篇 |
2005年 | 167篇 |
2004年 | 109篇 |
2003年 | 78篇 |
2002年 | 73篇 |
2001年 | 41篇 |
2000年 | 27篇 |
1999年 | 21篇 |
1998年 | 22篇 |
1997年 | 6篇 |
1996年 | 14篇 |
1995年 | 11篇 |
1994年 | 11篇 |
1993年 | 9篇 |
1992年 | 7篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 1篇 |
排序方式: 共有4569条查询结果,搜索用时 329 毫秒
91.
Pamela P. W. Lee Koon-Wing Chan Tong-Xin Chen Li-Ping Jiang Xiao-Chuan Wang Hua-Song Zeng Xiang-Yuan Chen Woei-Kang Liew Jing Chen Kit-Man Chu Lee-Lee Chan Lynette Pei-Chi Shek Anselm C. W. Lee Hsin-Hui Yu Qiang Li Chen-Guang Xu Geraldine Sultan-Ugdoracion Zarina Abdul Latiff Amir Hamzah Abdul Latiff Orathai Jirapongsananuruk Marco H. K. Ho Tsz-Leung Lee Xi-Qiang Yang Yu-Lung Lau 《Journal of clinical immunology》2013,33(7):1269-1270
92.
93.
The evolution, epidemiology and zoonotic aspects of Sapoviruses (SaV) are still not well explored. In this study, we applied high-resolution phylogeny to investigate the epidemiological and zoonotic origins as well as taxonomic classification of animal and human SaV. Bayesian framework analyses showed an increase in porcine SaV (PoSaV) population dynamics and genetic diversity between 1975 and 1982, resulting in a SaV gene flow and generation of new strains among porcine and human populations. Our results also show the contribution of different animal populations involved in SaV epidemiology and highlight zoonotic aspects, as exemplified by the crucial role that swine, dogs, mink and humans play in SaV spread. Additionally, phylogenetic analysis suggests that bats may play key role in SaV epidemiology. According to our hypothesis, these animals may act as reservoirs or intermediate host species, contributing to viral spread in zoonotic and other epidemiological scenarios and facilitating the generation of new SaV genogroups and genotypes through recombination events. Data from large-scale phylogeny partition based on patristic distance, did not show a correlation between transmission clusters on generation of SaV genogroups, nevertheless we present both important findings about SaV taxonomy and important considerations useful for further taxonomical studies. 相似文献
94.
《Health policy (Amsterdam, Netherlands)》2021,125(10):1377-1384
Best practices in team-based incentive design remain underexplored. This study examines under group-based pay-for-performance, how managers incentivize physicians for teamwork through internal feedback and payment distribution methods. In collaboration with Taiwan Association of Family Medicine, authors conducted a national survey of physician groups, with a response rate of 48.3%. Multilevel linear regression was applied to 134 groups, collectively consisting of 1,245 physicians in Taiwan. The outcome variables were two manager-rated scores for group performance on achieving (a) comprehensive, coordinated, continuous care, and (b) patient health improvement. The results indicate that providing each physician feedback on peer performance is superior to not providing it; when providing peer information within a group, concealing identities is superior to revealing them. These findings imply that application of the principle of social comparison can be effective; however, caution should be taken when disclosure of identifiable peer performance may intensify peer competition and undermine care coordination in team-based models. Further, groups that distribute payments equally among physicians perform better than groups that distributed payment proportionally to physicians’ patient shares. The findings are germane to small teams, where physicians do not have full control over care processes and outcomes, and need to work cooperatively to maximize group-based payment. 相似文献
95.
BackgroundProtein regulator of cytokinesis 1 (PRC1) has been reported to be implicated into the completion of cytokinesis and is dys-regulated in a cancer-specific manner. However, it roles in human prostate cancer (PCa) remain unclear. In the current study, we aimed to investigate the expression pattern of PRC1 and its clinical significance in this malignancy.Materials and methodsPRC1 protein expression in human PCa and non-cancerous prostate tissues was detected by immunohistochemistry, which was validated by microarray-based Taylor data at mRNA level. Then, the associations of PRC1 expression with clinicopathological features and clinical outcome of PCa patients were statistically analyzed.ResultsPRC1 expression in PCa tissues, at both mRNA and protein levels, were significantly higher than those in non-cancerous prostate tissues. In addition, the PCa patients with PRC1 overexpression more frequently had high Gleason score, advanced pathological stage, positive metastasis, short overall survival time and positive PSA failure than those with low Gleason score, early pathological stage, negative metastasis, long overall survival time and negative PSA failure (all P < 0.05). Moreover, PRC1 expression was identified as an unfavorable prognostic factor of biochemical recurrence-free survival in PCa patients (P < 0.001).ConclusionThese findings suggest that the aberrant expression of PRC1 may predict biochemical recurrence in men with PCa highlighting its potential as a prognostic marker of this malignancy. 相似文献
96.
目的观察内镜下探条扩张术治疗食管癌术后吻合口狭窄的近期疗效及护理配合。方法选择我院2011年收治的食管癌术后吻合口狭窄130例患者,行内镜下探条扩张术。结果所有患者接受探条扩张术后症状缓解.近期疗效明显。结论探条扩张安全,操作简单,并发症少,近期疗效好,适用于食管癌术后吻合口狭窄的治疗,操作的成功与否跟护士熟练的配合是密不可分的。 相似文献
97.
98.
99.
100.
《Vaccine》2018,36(36):5416-5423
Prophylactic human papillomavirus (HPV) vaccine represents a revolutionary step forward in preventing HPV-related cancers, especially cervical carcinoma. Alongside appropriate screening, it has the potential to dramatically reduce cervical cancer incidence and even eradicate it. Following extensive evaluations in clinical trials, the first decade of routine HPV vaccine use provides overwhelming evidence of the vaccines’ safety and their real-life effectiveness. In 2016, further clinical trials showed high vaccine efficacy in adult women, especially those that were HPV DNA-negative at baseline, and indicated possible protection from HPV-related diseases after treatment of precancerous cervical lesions. The recommendation for a two-dose schedule in individuals under 15 is further supported for all three licensed vaccines by immunogenicity studies that show non-inferior immune responses and similar clinical efficacy compared to the three-dose schedule. So far, natural competition between HPV types has not been confirmed and therefore vaccine-induced clinically significant type replacement is unlikely. The real-world effectiveness data showed cross-sectional reduction in the prevalence/incidence of vaccine-related HPV types, genital warts and precancerous cervical lesions in countries and regions with HPV vaccination coverage. These declines were evident not only in vaccinated females, but also in unvaccinated females and males, strongly suggesting herd protection. Despite an excellent safety profile consistently demonstrated in clinical trials and confirmed in real-life settings, recently invented controversial syndromes allegedly linked to HPV vaccines temporarily compromised some previously very successful vaccination programs and significantly contributed to the failure of HPV vaccine implementation in some countries with the highest prevalence of cervical cancer. However, several safety studies failed to confirm any association of these syndromes with HPV vaccination in various settings and geographic locations. The main challenges remain implementing HPV vaccination in national vaccination programs, especially in low-and middle-income countries with the highest burden of cervical cancer, and achieving and sustaining high vaccine coverage rates. 相似文献