化学振荡技术在中药研究中的应用

中药是一个多组分的复杂体系,质量监控因多方面因素较难实现,虽已有高效液相色谱等多种分析方法,但仍不十分理想,因此,有不少学者针对中药特性开展了多方面研究,力求开发一种既简便,又快捷,且能反映中药特性的分析方法。探讨采用电化学手段和振荡技术,获取中药及其制剂的特征振荡指纹图谱,依据图谱所反映的信息,确定中药种类及有关成分的量;通过15种草药和六味地黄中成药的振荡图谱,探讨了建立中药特征振荡图谱的理论,并进行了反应机制研究;介绍了中药特征振荡指纹图谱的研究方案及拟解决的关键问题;讨论了振荡体系对中药振荡图谱的影响,给出了中药振荡反应振荡系数的研究方法,基于图谱进行了动力学和反应机制研究。这种方法克服了中药化学成分复杂,相互干扰严重,难以确认的弊端,是一种新的研究手段。     

精神心理、社会环境因素与妊高征关系的研究进展

随着生物医学模式向生物—心理—社会医学模式的转变 ,心理社会因素与妊高征的关系愈来愈受到医学界的普遍关注和重视。该文对精神心理因素、社会环境因素与妊高征发生、发展的关系及其原因作一综述。     

卡托普利、双克联合二甲双胍治疗原发性高血压伴胰岛素抵抗的临床观察

目的观察卡托普利、双克联合二甲双胍对原发性高血压伴胰岛素抵抗(IR)患者相关参数的影响。方法90例原发性高血压伴IR患者,随机分为治疗组和对照组。治疗组给予卡托普利、双克加二甲双胍片,对照组单纯用卡托普利、双克,治疗前、后均作口服糖耐量试验、胰岛素释放试验及血压监测。结果两组收缩压与舒张压均下降,治疗组下降更显著。治疗组空腹胰岛素及餐后胰岛素均下降,与对照组相比有显著性差异(P<0.05)。结论卡托普利、双克联合二甲双胍可明显改善IR,更有效降低血压。     

Enhancement of Viability of Fat Grafts in Nude Mice by Endothelial Progenitor Cells

BACKGROUND: A recent discovery showed that endothelial progenitor cells (EPCs) could augment collateral vessel growth to ischemic tissues. OBJECTIVE: The objective was to demonstrate the effects of EPCs on the vasculogenesis and survival of free transplanted fat tissues in nude mice. METHODS: EPCs from human donors were cultured in vitro for 7 days. Human fat tissues were injected subcutaneously into the scalps of 20 6-week-old nude male mice. EPCs stained with CM-DiI were mixed with the transplanted fat tissues and injected into the mice. EBM-2 medium was used as control group. The animals were euthanized 15 weeks after the procedure. Graft volume were measured, and histologic evaluation was performed. The central part of fat tissues was histologically evaluated 15 weeks after the fat injection. RESULTS: The survival volume of the experimental group was significantly greater than that of the control group (p< .05). Less cyst formation and fibrosis was obtained in the experimental group. Histologic evaluation of the central part of fat tissues 15 weeks after the fat injection showed that capillary densities increased markedly in the experimental group mice. CONCLUSION: The results indicate that EPCs have the ability to enhance the survival and the quality of the transplanted fat tissues.     

低场强MRI对主动脉夹层的诊断价值

目的 评价低场强磁共振成像对主动脉夹层的诊断价值。方法 对16例主动脉夹层在低场强MRI自旋回波（SE）序列和梯度回波（GRE）表现进行回顾性分析总结，其中，6例经手术病理证实。结果 16例均能清晰显示病变的范围、夹层起始部位、内膜片、真假腔，6例假腔内显示血栓。结论 低场强MRI作为一种无创性检查能对主动脉夹层作出准确及时的诊断。