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31.
Xiao-hong Liu Jie Qiao Rong Li Li-ying Yan Li-xue Chen 《Journal of assisted reproduction and genetics》2013,30(6):813-819
Purpose
To explore whether the presence of a Y chromosome AZFc microdeletion confers any adverse effect on the outcomes of intracytoplasmic sperm injection (ICSI) with fresh ejaculated sperm.Methods
A total of 143 oligozoospermia patients with Y chromosome AZFc microdeletion in ICSI cycles in a five-year period were studied. Infertile men with normal Y chromosome in ICSI at the same time-frame were used as controls matched to the study group for age of female, female’s body mass index, male’s age, infertility duration and number of oocytes retrieved. Retrospective case–control study was used.Results
There were no significant differences between groups in clinical outcomes of endometrial thickness, transferred embryos, good embryo rates, implantation rates, biochemical pregnancy rates, clinical pregnancy rates, ectopic pregnancy rates, miscarriage rates, preterm birth rates, the ratio of male and female babies, newborn body height, newborn weight, low birth weight and birth defects (P > 0.05). Patients with Y chromosome AZFc microdeletion had a lower fertilization rate (61.8 % vs. 67.8 %, P < 0.05) and higher cleaved embryo rate (94.0 % vs. 88.1 %, P < 0.05).Conclusions
ICSI clinical outcomes for oligozoospermic patients with Y chromosome AZFc microdeletion are basically comparable to that of infertile patients with normal Y chromosomes. The results of ICSI were not affected by the AZFc deletion. Preimplantation genetic diagnosis (PGD) before ICSI for Y chromosome AZFc microdeletion may not be a justifiable regular procedure if the couples didn’t care the vertical transmission of Y chromosome deletion. 相似文献32.
目的探究本院孕35周前未足月胎膜早破(preterm premature rupture of membrane,PPROM)孕妇中B族链球菌(group B streptococcus,GBS)筛查的阳性率及GBS阳性的PPROM孕妇的围产结局。方法选取2018年1月至2019年12月本院收治的28~35周PPROM孕妇417例,均于入院后行B族链球菌筛查,其中阳性43例为观察组,阴性374例为对照组。比较两组孕妇围产结局。结果PPROM孕妇GBS阳性率为10.3%(43/417),同期足月PROM孕妇GBS阳性率为9.2%(164/1785),差异无统计学意义。观察组宫腔感染+产褥感染发生率明显高于对照组,差异有统计学意义(P<0.05)。观察组新生儿感染及新生儿高胆红素血症发生率均明显高于对照组,差异有统计学意义(P<0.05)。观察组早产儿在儿科住院时间明显长于对照组,差异有统计学意义(P<0.05)。结论GBS携带并未增加PPROM的发生率,但PPROM孕妇中GBS阳性者围产结局更差。 相似文献
33.
目的 探讨转化生长因子-α(TGF-α)和表皮生长因子受体(EGFR)在人胎儿卵巢的表达与定位及培养前后的变化。方法 收集20份胎龄为16-40周因各种原因死亡的女性胎儿卵巢标本,对其中10份卵巢标本分3,6,9d进行组织培养,采用免疫组织化学方法测定TGF-α和EGFR蛋白在人胎儿卵巢组织中的表达。结果 TGF-α在17份胎儿卵巢卵母细胞,7份卵泡细胞及13份基质细胞有性表达,EGFR在19份卵 相似文献