矽肺动物模型全肺灌洗治疗的病理观察

通过对动物模型实验治疗的病理观察，评价全肺大容量灌洗治疗矽肺的效果，并优选灌洗液。对４０只家兔和１０只幼猪经ＳｉＯ２染尘处理后，各随机分为药物组、盐水组和对照组。４～５周后施行全肺大容量灌洗。治疗后３～５个月处死各组动物，进行病理双盲检查。经统计学秩和检验，兔与猪各组肺矽结节纤维化级别分布的差异有非常显著意义（Ｐ＜０．００５）。经卡方检验，各灌洗组的纤维化程度与对照组相比，差异亦有非常显著意义（Ｐ＜０．０１）。灌洗液中药与盐水比，Ｐ＜０．０５；盐水与西药比，Ｐ＜０．０５。兔和猪矽肺各灌洗组的效果明显优于对照组。灌洗液中药优于盐水，盐水又优于西药     

Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: A phase 3, multicenter,randomized, double-blind,double-dummy,active-controlled,non-inferiority trial

Background/Purpose

Nemonoxacin is a novel nonfluorinated quinolone with excellent in vitro activity against most pathogens in community-acquired pneumonia (CAP), especially Gram-positive isolates. The purpose of this study was to assess the efficacy and safety of nemonoxacin compared with levofloxacin in patients with CAP.

Identification of peptides presented through the MHC-II of dendritic cells stimulated with Mycobacterium avium

Mycobacterium avium (M. avium) represents a species of concern, because of its ability to modulate the host’s innate immune response, and therefore influence trajectory of adaptative immunity. Since eradicative response against mycobacteria, and M. tuberculosis/M. avium, relies on peptides actively presented on a Major Histocompatibility complex-II (MHC-II) context, we assessed paradoxical stimulation of Dendritic Cell resulting on immature immunophenotype characterized by membrane minor increase of MHC-II and CD40 despite of high expression of the pro-inflammatory tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in supernatants. Identification of M. avium leucine rich peptides forming short α-helices shutting down Type 1T helper (Th1), contribute to the understanding of immune evasion of an increasingly prevalent pathogen, and may provide a basis for future immunotherapy to infectious and non-infectious disease.     

放射性核素胶体32p在胸壁小切口胸腔镜治疗Ⅱ期肺癌中的应用

目的探讨放射性核素胶体32p 在胸壁小切口辅助电视胸腔镜肺叶切除治疗Ⅱ期肺癌中应用的可能性。方法在双腔管气管插管常规全麻下实施电视胸腔镜手术。术中健侧肺单肺通气,第4或第5肋间8～10cm 切口,辅助胸腔镜下肺叶切除及清扫淋巴结,对手术中认为淋巴结清扫不彻底及淋巴结转移区域,局部注射放射性核素胶体32pMBq(5～10mCi)。结果 29例病人在 VEMAST 下完成肺叶切除,1例因肺动脉肿瘤包裹,术中出血改在常规开胸下完成肺叶切除,另1例因肺动脉无法与肿瘤分离而中转手术,无手术死亡,无严重并发症,无放射性核素胶体32p 不良反应。结论胸壁小切口辅助电视胸腔镜肺叶切除治疗Ⅱ期肺癌时,对手术中认为切除不满意或淋巴结转移处施行了放射性核素治疗。小切口辅助 VATS 下肺叶切除、使用放射性核素胶体32p 有选择的治疗Ⅱ期肺癌是一种安全有效的治疗方法。     

Concurrent and cross-season protection of inactivated influenza vaccine against A(H1N1)pdm09 illness among young children: 2012–2013 case–control evaluation of influenza vaccine effectiveness

In 2012–2013, we examined 1729 laboratory-confirmed A(H1N1)pdm09 influenza cases matched 1:1 with healthy controls and estimated influenza vaccine effectiveness (VE) for trivalent inactivated influenza vaccine (IIV3) to be 67% (95% confidence interval = 58–74%) for ages 8 months to 6 years old. Among children aged 8–35 months old, VE for fully vaccinated children (73%, 60–81%) was significantly higher than VE for partially vaccinated children (55%, 33–70%). Significant cross-season protection from prior IIV3 was noted, including VE of 31% (8–48%) from IIV3 received in 2010–2011 against influenza illness in 2012––2013 without subsequent boosting doses.     

肺腺癌T1N0M0的预后因素分析

目的：探讨肺腺癌T1N0M0患预后的病理因素与生存率的关系。方法：回顾1994年－1997年经手术治疗的肺腺癌T1N0M0 34例。观察病理学特征并随访。结果：34例病例术后平均随访时间为5．1年，5年生存率为67．7％。肿瘤直径2－3cm；中心性纤维化＞30％；有淋巴管腔的侵犯；细胞核Ⅲ级与肿瘤坏死＞50％，明显降低5年生存率。结论：研究有利于检测出转移风险较大的患，使其及时接受辅助性系统治疗。