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Zichen Hao Jun Li Bo Li Kareme D Alder Sean V Cahill Alana M Munger Inkyu Lee Hyuk-Kwon Kwon JungHo Back Shuogui Xu Min-Jong Kang Francis Y Lee 《Journal of bone and mineral research》2021,36(1):186-198
Smokers are at a higher risk of delayed union or nonunion after fracture repair. Few specific interventions are available for prevention because the molecular mechanisms that result in these negative sequelae are poorly understood. Murine models that mimic fracture healing in smokers are crucial in further understanding the local cellular and molecular alterations during fracture healing caused by smoking. We exposed three murine strains, C57BL/6J, 129X1/SvJ, and BALB/cJ, to cigarette smoke for 3 months before the induction of a midshaft transverse femoral osteotomy. We evaluated fracture healing 4 weeks after the osteotomy using radiography, micro-computed tomography (μCT), and biomechanical testing. Radiographic analysis demonstrated a significant decrease in the fracture healing capacity of smoking 129X1/SvJ mice. μCT results showed delayed remodeling of fracture calluses in all three strains after cigarette smoke exposure. Biomechanical testing indicated the most significant impairment in the functional properties of 129X1/SvJ in comparison with C57BL/6J and BALB/cJ mice after cigarette smoke exposure. Thus, the 129X1/SvJ strain is most suitable in simulating smoking-induced impaired fracture healing. Furthermore, in smoking 129X1/SvJ murine models, we investigated the molecular and cellular alterations in fracture healing caused by cigarette smoking using histology, flow cytometry, and multiplex cytokine/chemokine analysis. Histological analysis showed impaired chondrogenesis in cigarette smoking. In addition, the important reparative cell populations, including skeletal stem cells and their downstream progenitors, demonstrated decreased expansion after injury as a result of cigarette smoking. Moreover, significantly increased pro-inflammatory mediators and the recruitment of immune cells in fracture hematomas were demonstrated in smoking mice. Collectively, our findings demonstrate the significant cellular and molecular alterations during fracture healing impaired by smoking, including disrupted chondrogenesis, aberrant skeletal stem and progenitor cell activity, and a pronounced initial inflammatory response. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献
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Shu-Nan Qi Yong Yang Yu-Jing Zhang Hui-Qiang Huang Ying Wang Xia He Li-Ling Zhang Gang Wu Bao-Lin Qu Li-Ting Qian Xiao-Rong Hou Fu-Quan Zhang Xue-Ying Qiao Hua Wang Gao-Feng Li Yuan Zhu Jian-Zhong Cao Jun-Xin Wu Tao Wu Su-Yu Zhu Mei Shi Li-Ming Xu Zhi-Yong Yuan Hang Su Yu-Qin Song Jun Zhu Chen Hu Ye-Xiong Li 《American journal of hematology》2020,95(9):1047-1056
We aimed to determine the survival benefits of chemotherapy (CT) added to radiotherapy (RT) in different risk groups of patients with early-stage extranodal nasal-type NK/T-cell lymphoma (ENKTCL), and to investigate the risk of postponing RT based on induction CT responses. A total of 1360 patients who received RT with or without new-regimen CT from 20 institutions were retrospectively reviewed. The patients had received RT alone, RT followed by CT (RT + CT), or CT followed by RT (CT + RT). The patients were stratified into different risk groups using the nomogram-revised risk index (NRI). A comparative study was performed using propensity score-matched (PSM) analysis. Adding new-regimen CT to RT (vs RT alone) significantly improved overall survival (OS, 73.2% vs 60.9%, P < .001) and progression-free survival (PFS, 63.5% vs 54.2%, P < .001) for intermediate-risk/high-risk patients, but not for low-risk patients. For intermediate-risk/high-risk patients, RT + CT and CT + RT resulted in non-significantly different OS (77.7% vs 72.4%; P = .290) and PFS (67.1% vs 63.1%; P = .592). For patients with complete response (CR) after induction CT, initiation of RT within or beyond three cycles of CT resulted in similar OS (78.2% vs 81.7%, P = .915) and PFS (68.2% vs 69.9%, P = .519). For patients without CR, early RT resulted in better PFS (63.4% vs 47.6%, P = .019) than late RT. Risk-based, response-adapted therapy involving early RT combined with CT is a viable, effective strategy for intermediate-risk/high-risk early-stage patients with ENKTCL in the modern treatment era. 相似文献
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外伤性迟发性颅内血肿常规CT研究 总被引:2,自引:0,他引:2
目的探讨常规CT如何尽早而准确地测出外伤性迟发性颅内血肿。方法搜集常规CT复查证实的外伤性迟发性颅内血肿39例,对其首次常规CT检查及复查的CT图像特点进行分析。结果 39例迟发性颅内血肿首次常规CT检查主要异常表现包括:①局限性蛛网膜下腔出血30例。②局限性脑密度减低,灰白质分界不清15例。③局部轻度占位效应18例。④颅骨骨折5例。结论外伤性迟发性颅内血肿的发生率与伤后首次常规CT检查表现密切相关,应在24 h以内复查,以6~12 h最佳。 相似文献
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Yan Gao MD Yizhen Liu MD PhD Yafei Wang MD Qingyuan Zhang MD Depei Wu MD Xu Ye MD Jianqiu Wu MD Wei Xu MD Jianfeng Zhou MD Yu Yang MD Hong Cen MD Feng Zhang MD Ying Xiang MD Xiaoqiong Tang MD Kaiyang Ding MD JinYing Lin MD Lei Ma MD Shunqing Wang MD Hao Yu MD Yang Zhao MD Bin Song MD Fangfang Lv MD Huiqiang Huang MD 《Cancer》2023,129(4):551-559
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Glycemic status and chronic kidney disease in Chinese adults: Findings from the REACTION study
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Lin Lin Jieli Lu Lulu Chen Yiming Mu Zhen Ye Chao Liu Gang Chen Lixin Shi Jiajun Zhao Qiang Li Tao Yang Li Yan Qin Wan Shengli Wu Yan Liu Guixia Wang Zuojie Luo Xulei Tang Yanan Huo Zhengnan Gao Qing Su Youmin Wang Guijun Qin Huacong Deng Xuefeng Yu Feixia Shen Li Chen Liebin Zhao Yu Xu Min Xu Kui Peng Rui Du Meng Dai Mian Li Tiange Wang Zhiyun Zhao Shenghan Lai Donghui Li Yufang Bi Weiqing Wang Guang Ning 《Journal of Diabetes》2017,9(9):837-845
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目的: 探讨乳腺原发性浆细胞瘤的临床病理特点以及诊断和鉴别诊断。方法: 对2例乳腺原发性浆细胞瘤进行临床病理学分析及免疫组织化学观察,并复习相关文献。结果: 1例为乳腺双侧同时原发性浆细胞瘤,另1例为乳腺单侧孤立性原发性浆母细胞瘤。临床表现肿块无明显症状,镜下浆细胞瘤多数与正常浆细胞相似,散在多见异常和不典型瘤细胞,核分裂象可见;浆母细胞瘤有弥漫大片分布的大圆或卵圆形细胞增生,细胞核居中有明显核仁,核分裂象多见。2例均表达CD138、CD38、多发性骨髓瘤致癌蛋白;重链IgM均阳性,例1表达轻链κ,例2表达轻链λ。浆细胞瘤Ki-67 20%阳性,浆母细胞瘤70%阳性。结论: 乳腺原发性浆细胞瘤病理诊断的主要依据是组织形态和免疫表型。须与浆细胞乳腺炎及浸润性小叶癌相鉴别,治疗以手术切除结合放射治疗效果较好。 相似文献
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Huijuan Zou Beili Chen Ding Ding Ming Gao Dawei Chen Yajing Liu Yan Hao Weiwei Zou Dongmei Ji Ping Zhou Zhaolian Wei Yunxia Cao Zhiguo Zhang 《Journal of pineal research》2020,68(1):e12621
Melatonin (MT) regulates reproductive performance as a potent antioxidant; however, its beneficial effects on oocyte development remain largely unknown, especially in human oocytes. The collected 193 immature oocytes from the controlled ovarian hyperstimulation (COH) cycle underwent in vitro maturation (IVM) in IVM medium contained 10 μmol/L MT (n = 105, M group) and no MT (n = 88, NM group), followed by insemination and embryo culture. The results showed that the high-quality blastocyst formation rate in the M group (28.4%) was significantly higher than that in the NM group (2.0%) (P = .0001), and the aneuploidy rate was low (15.8%). In the subsequent clinical trials, three healthy infants were delivered. Next, single-cell RNA-seq data revealed 1026 differentially expressed genes (DEGs) between the two groups, KEGG enrichment analysis revealed that the majority of DEGs involved in oxidative phosphorylation pathway, which associated with ATP generation, was upregulated in the M group. Finally, confocal fluorescence staining results revealed that the mitochondrial membrane potential in the oocytes significantly increased and intracellular ROS and Ca2+ levels greatly decreased in the M group. Melatonin can promote the development of immature human oocytes retrieved from the COH cycle into healthy offspring by protecting mitochondrial function. 相似文献
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Lei Gong PhD Chuan Wang PhD Guang Ning PhD Weiqing Wang PhD Gang Chen PhD Qin Wan PhD Guijun Qin PhD Li Yan PhD Guixia Wang PhD Yingfen Qin PhD Zuojie Luo PhD Xulei Tang PhD Yanan Huo PhD Ruying Hu PhD Zhen Ye PhD Lixin Shi PhD Zhengnan Gao PhD Qing Su PhD Yiming Mu PhD Jiajun Zhao PhD Lulu Chen PhD Tianshu Zeng PhD Xuefeng Yu PhD Qiang Li PhD Feixia Shen PhD Yinfei Zhang PhD Youmin Wang PhD Huacong Deng PhD Chao Liu PhD Shengli Wu PhD Tao Yang PhD Yufang Bi PhD Jieli Lu PhD Mian Li PhD Yu Xu PhD Min Xu PhD Tiange Wang PhD Zhiyun Zhao PhD Xinguo Hou PhD Li Chen PhD 《Diabetes, obesity & metabolism》2021,23(11):2551-2560
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Yihebali Chi Yongqian Shu Yi Ba Yuxian Bai Baoli Qin Xiuwen Wang Jianping Xiong Nong Xu Helong Zhang Jianfeng Zhou Jianming Xu Ying Cheng Jifeng Feng Chunhong Hu Yigui Chen Zhendong Chen Jufeng Wang Chengxue Dang Jianhong Wang Yiye Wan Yong Tang Donglin Wang Jiang liu Minhui Wu Yanhong Deng Xingwen Li Yongqiang Li Jian Dong Da Jiang Guisheng Li Qiong Wu Jin Li Yujuan Qi Yongkun Sun Jianqiang Cai 《The oncologist》2021,26(10):e1693-e1703