四种物理疗法对葡萄球菌影响的实验观察

综合四种物理疗法,对革兰氏阳性葡萄球菌影响的实验观察报道较少。为了更好的使人工物理疗养因子应用于临床,我们实验表明,激光照射15分钟,细菌生长良好,20—30分钟后有一般的抑菌作用。接受超短波和微波辐射后细菌均生长良好,无直接杀灭细菌的作用,紫外线15个生物剂量照射后,还有7—8个菌落生长,30个生物剂量照射后无葡萄球菌生长。本实验证明,紫外线剂量要根据需要掌握,才能起到完全杀灭细菌的作用。     

周期性发热为特征的恶性组织细胞病一例

患者男，３５岁。广州人。周期性发热１个月，于１９９７年７月７日转入血液科。６月初患者突发畏寒、高热，以“发热待查”收入传染科。查体：体温４０℃。无皮疹，浅表淋巴结无肿大。胸骨无压痛，心肺无异常，肝未及，脾肋下２．０ｃｍ。血象：Ｈｂ１３０ｇ／Ｌ，ＷＢＣ...     

253株致病性葡萄球菌青霉素药敏实验分析

２５３株致病性葡萄球菌青霉素药敏实验分析张新友，高志英（辽宁兴城市空军兴城疗养院，１２５１００）葡萄球菌是广泛地分布于自然界中最常见的化脓性球菌之一。极易在人群之间传播，尤以耐药菌株更为常见，为给临床合理使用抗生素提供参考依据，本文就我院１９７８年以...     

磁化矿泉水浴对正常人某些生化指标影响的观察

本文通过实验证明,磁化矿泉水作用正常人体后,使机体血清中谷丙转氨酶、免疫球蛋白IgG、补体C_3、中性粒细胞均有增加(P<0.01)有显著性意义。而血脂、胆固醇均有降低,其中胆固醇降低较为明显,有统计学意义。免疫球蛋白的IgA、IgM,血色素、红细胞,淋巴细胞,有变化,但无显著性差异。磁化兴城矿泉水浴后能使体内的免疫功能增强。本实验为临床更好的利用矿泉因子提供了可靠的理论依据。     

Comparison of Mitoxantrone in Combination with Intermediate-dose Cytarabine <Emphasis Type="Italic">versus</Emphasis> High-dose Cytarabine as Consolidation Therapies for Young Non-APL Acute Myeloid Leukemia Patients with Favorable and Intermediate Cytogenetics

In this study, we compared the efficacy of mitoxantrone in combination with intermediate-dose cytarabine (HAM) with that of high-dose cytarabine alone (HiDAC) as consolidation regimens in non-acute promyelocytic leukemia (APL) acute myeloid leukemia patients with favorable and intermediate cytogenetics. A total of 62 patients from Shenzhen People's Hospital were enrolled in this study. All patients enrolled received standard induction chemotherapy and achieved the first complete remission (CR1). In these patients, 24 received HiDAC and 38 received HAM as consolidation. The median relapse free survival (RFS) and overall survival (OS) were similar between these two consolidation regimens. Even in subgroup analysis according to risk stratification, the combination regimen conferred no benefit in longterm outcome in patients with favorable or intermediate cytogenetics. However, in patients receiving HAM regimen, the lowest neutrophil count was lower, neutropenic period longer, neutropenic fever rate higher, and more platelet transfusion support was required. HAM group also tended to have higher rate of sepsis than HiDAC group. According to our results, we suggest that combination treatment with mitoxantrone and intermediate-dose cytarabine has limited value as compared to HiDAC, even in young non-APL AML patients with favorable and intermediate cytogenetics.     

浅谈影响中药材质量的因素

本文从中药材的产地、采收、加工、流通、贮藏、保管等几个方面系统分析现在中药材质量低下 的原因,为保证中药材质量的稳定性提出了较为全面的建议,对“GAP”管理寄于很大的希望,规范中药 材的种、采、挖、炮、运、贮,确保中药材质量的稳定性以达到预期疗效,为人类健康事业提供保证。     

WICA算法在脑电P300波成分提取中的应用研究

目的:研究新的脑电波成分提取方法,以便更有效地提取脑电P300波成分.方法:根据脑电信号以及信号分析方法各自的特点,把小波变换(WT)和独立分量(ICA)相结合的方法(WICA)应用到脑电P300波成分提取中.结果:小波变换可以增强待检测信号成分,削弱非目标信号成分和噪声的干扰;在经过小波变换后子带重组的多道ICA输入信号中,非目标信号成分和干扰信号成分已变得较弱,因此WICA算法能有效地分离出相对较强的目标信号成分.结论:实验结果表明,WICA算法在脑电P300波成分提取中取得了比较理想的效果.     

BCL-2抑制剂在血液恶性肿瘤中的靶向治疗应用及作用机制

细胞凋亡受到抑制是血液恶性肿瘤细胞的突出特征。B细胞淋巴瘤-2(B-cell lymphoma-2,BCL-2)是细胞凋亡关键性蛋白调节因子,在多种血液恶性肿瘤中有不同程度的表达。高表达BCL-2的肿瘤细胞抗细胞凋亡能力显著增强,靶向抑制BCL-2成为抗血液肿瘤的研究热点之一。维奈克拉是首个获批上市的BCL-2抑制剂(BCL-2 inhibitor, BCL-2i),用于慢性淋巴细胞白血病、急性髓系白血病及骨髓增生异常综合征的治疗。研究表明维奈克拉对其他血液恶性肿瘤如B细胞非霍奇金淋巴瘤及多发性骨髓瘤也具有抗肿瘤活性。本文就BCL-2抗凋亡机制、BCL-2i在血液恶性肿瘤中的临床应用以及BCL-2i耐药的可能机制作一简要综述。