乙型肝炎甲胎蛋白检测与重型肝炎预后指数评估的意义

给慢性活动肝炎患者输注人胎肝细胞悬液引起血清甲胎蛋白增高反应的初浓度为２０２±３８．３μｇ／Ｌ，其半衰期为１．７天；分布池为６．９一１０．２升。重型肝炎生存组血清甲胎蛋白显著高于死亡组，生存组甲胎蛋白与血清总胆红素呈非常显著相关，而死亡组两者无相关性。重型肝炎患者输注胎肝悬液后其血清甲胎蛋白进一步升高者，预后较好。取重型肝炎预后指数０．１为重型肝炎生死的截断点，判断预后的灵敏度、特异度、准确度和阳性预告值分别为７９．５％、８９．６％、８４．８％和８７．５％。重型肝炎预后指数的计算可作为判断预后与新疗法疗效的指标。     

Relationship among dosages of aminophylline, plasma levels of theophylline and variation of pulmonary arterial pressure]

The relationship among the dosages of aminophylline, plasma levels of theophylline and variations of mean pulmonary arterial pressure (mPAP) in 72 patients with COPD was investigated. The results showed that after a different loading dosage of aminophylline (6 mg/kg, 5 mg/kg and 4 mg/kg) was administered by intravenous injection, mPAP in the 6 mg/kg group was decreased more significantly (P less than 0.01) than that in the 4 mg/kg group. In the 6 mg/kg group, the decreased mPAP period sustained for 120 min, which was longer than that in the other 2 groups. The plasma levels of theophylline in the 6 mg/kg group of patients 30 to 120 min after loading dose injected were 115.54-79.04 mumol/L, which were higher than that in the others. Within the 120 min period of observation after the drug was administered no patients in any of these groups showed severe untoward effects. According to the results of this experiment, we suggest that the 6 mg/kg as a loading dose should be advised for the treatment of pulmonary hypertension in COPD. The optimum time to give the maintenance dosage should be set within 2 h after the loading dose. It is necessary to monitor the plasma levels of theophylline while aminophylline is administered, so that optimal therapeutic effects could be achieved without side effects.     

天然有机分子精细立体结构规律的初步研究Ⅱ．影响熔点的结构因素

应用Ｘ衍射方法测定雷公藤两个化合物的晶体结构，并对影响固体熔点的结构因素进行分析。晶型（或空间对称群）、结晶溶剂、分子间作用力及分子构象的精细变化均可导致晶态物质的熔点变化。     

乙酰胆碱参与皮层下行调制疼痛的作用

<正> 我们实验室的工作曾报导,刺激猫的皮层SⅡ区、SⅠ区或十字沟前区可抑制丘脑髓板内核群神经元的伤害性反应及针刺镇痛效应。相继刺激大鼠的皮层SmⅠ区也获     

不同饮水类型的若干癌症发病率研究

应用回顾前瞻性方法，在海宁市随机选择了８个乡（镇）作为研究区。１９７７至１９８８年间，研究区共有癌症病例１９８８人。研究结果示，饮用池塘水的肝、肺、胃、食道及结直肠的癌症平均发病率男女均为最高；而饮用井水的上述５种癌症的平均发病率最低。在各饮水类型问对各种癌症的平均发病率作了Ｐｏｉｓｓｏｎ检验，结果差异有统计学意义。将饮用井水作为非暴露，作相对危险度分析。表明饮用河水的ＲＲ值高达７．７９～１４．２５；饮用池塘水的ＲＲ则更高（２．５５～３６．９９）。本文揭示了不同饮水类型癌症发病率的差异及其联系。     

自制与进口氯化十六烷基吡啶抑菌作用的比较研究

以液体稀释法比较了自制与进口十六烷基吡啶作用于4种口腔常见微生物的最低抑菌浓度和最低杀菌浓度的实验结果,经t检验证明两者间无显著差异,提示自制氯化十六烷基吡啶的药效质量可靠。并就控制接种菌量及杀菌机理等问题作了初步探讨。     

Malignant melanoma metastatic to the stomach: upper G-I endoscopic finding--report of a case

a 54-year-old male was presented with huge, black, ulcerative and painless tumor of the sole of left foot. Malignant melanoma was proved by biopsy, but patient refused any treatment. He visited our hospital again when bloody vomitus was noted two months later. Chest P-A revealed multiple lung metastases, and marked liver metastasis was also found by abdominal echo. Upper gastrointestinal (UGI) panendoscopy revealed multiple melanotic nodules with ulcerations at the tip, scattering diffusely on the fundus and upper body of the stomach. Metastatic malignant melanoma was proved by endoscopic biopsy. Metastatic tumor of the stomach was rare, and the endoscopic finding of the malignant melanoma with gastric metastasis was more rarer in the literature in Taiwan. So we would like to present the very rare finding of the endoscopy.     

成人结核性脑膜炎误诊原因分析

报告了成人结核性脑膜炎11例误诊,并收集国内报告的221例误诊病例,对结核性脑膜炎的误诊原因进行了综合分析。     

β2mG McAb RIA法研究EPO对CRF患者肾功能的影响

β2微球蛋白(β2mG)已作为检测肾脏功能的灵敏指标应用于临床。重组人红细胞生长素(rHuEPO)是治疗慢性肾功能衰竭(CRF)的药物。本文采用β2mG-McAb宽检测范围(0.31～10μg/ml)的RIA,观察15例CRF患者用rHuEPO治疗后,对贫血和肾功能的影响。结果表明:治疗后,患者Hb明显升高(P<0.01),但血清β2mG与治疗前(25.52±1.76μg/ml)无明显差异。提示rHuEPO对于肾脏功能没有改善和恶化作用,而有改善贫血的效果。