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经过药物筛选发现大叶牛奶菜对SD大鼠具有抗生育作用,从其甲醇提取物中分得大叶牛奶菜甙甲(Marsdckoiside A,1)及大叶牛奶菜甙乙(Marsdekoiside B,2),根据波谱分析和水解产物与标准品对照确定了它们的结构,证明二者都是新化合物。动物实验甲具有抗生育活性。 相似文献
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从萝摩科植物喙柱牛奶菜(Marsdenia oreophila W.W.Sm)茎中首次分得 4种结晶性成分,经波谱分析(IR,MS,~1H-NMR,~(13)C-NMR)及物理化学方法分别鉴定为α-香树脂醇棕榈酸酯(α-amyrin palmitate,Ⅰ),α-香树脂醇己酸酯(α-amyrin caproate,Ⅱ),α-香树脂醇丁酸酯(α-amyrin bu-tyrate,Ⅲ)和β-谷甾醇(β-sitosterol,Ⅳ)。 相似文献
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This study investigated the effect of diosgenin, a natural sapogenin possessing various pharmacological activities, on benign prostatic hyperplasia (BPH) in rats and the possible mechanisms. BPH was established in the castrated rats by subcutaneous injection of testosterone propionate. Animals were randomly divided into four groups (n=10 each): model group (0.5% sodium carboxymethyl cellulose); positive control group (3 mg/kg finasteride); two diosgenin groups (50 and 100 mg/kg). The drugs were intragastricaly given in each group for consecutive 3 weeks. Another 10 rats with no testicles cut off served as negative controls and they were subcutaneously injected with 0.1 mL olive oil per day and then treated with 0.5% sodium carboxymethylcellulose. After 3-week administration, the prostate index and serum PSA level were determined, and histopathological examination was carried out. The levels of MDA, SOD and GPx in prostates were also measured. Additionally, the expression of Bcl-2, Bax and p53 was examined using Western blotting. The results showed that the prostate index and serum PSA level were significantly decreased, and the pathological changes of the prostate gland were greatly improved in diosgenin groups as compared with the model group. Elevated activities of SOD and GPx, and reduced MDA level were also observed in diosgenin-treated rats. In addition, the expression of Bcl-2 in prostates was down-regulated, whereas that of Bax and p53 was up-regulated in diosgenin-treated rats. These results indicated that diosgenin was effective in inhibiting testosterone propionate-induced prostate enlargement and may be a candidate agent for the treatment of BPH. 相似文献
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针毛蕨的化学成分及其体内外抗肿瘤活性研究 总被引:2,自引:0,他引:2
目的 研究针毛蕨(Macrothelypteris oligophlebia化学成分及其体内外抗肿瘤活性。方法 采用各种色谱技术进行分离纯化,根据理化性质和波谱数据进行结构鉴定,以MTT法测试各化合物对肿瘤细胞的体外抑制作用,并观察针毛蕨提取物对S180肉瘤小鼠肿瘤生长的影响。结果 分离得到7个黄酮类化合物,分别鉴定为:荚果蕨素(1、柚皮素(2、柚皮素-5-O-β-D-吡喃葡萄糖苷(3、原芹菜素(4、去甲氧基荚果蕨素(5、芹菜素(6和原芹菜素-4′-O-β-D-葡萄糖苷(7。结论 所有化合物均首次从针毛蕨中分离得到;化合物4对肿瘤细胞增殖有显著的抑制作用,且呈现出良好的剂量依赖性;体内抗肿瘤试验显示针毛蕨提取物对S180肉瘤小鼠肿瘤的生长有明显的抑制作用。 相似文献
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