The Experimental Study on Treatment of Glucocorticoid-Induced Ischemic Necrosis of Femoral Head by Gu Fu Sheng Capsule

Objective: To observe the effects of Gu Fu Sheng Capsule (骨复生胶囊 GFSC) on nitric oxide (NO) level and fibrinolytic activity in rabbits with glucocorticoid-induced ischemic necrosis of femoral head (GINFH)so as to explain the therapeutic mechanism of GFSC Methods: 48 rabbits were randomly divided into 4 The models of GINFH were produced by injection of glucocorticoid hormone for 8 weeks. From the 9th week, GFSC decoction was given to the rabbits of the group A (45g. kg-1 d-1) and MSGP extract was given to the group B (0.17 g kg-1 d-1) and the same volume of normal saline to group C and D by intragastric infusion. The content of plasma nitric oxide (NO), and activities of tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor (PAI) were detected after the hormone was injected for 4 and 8 weeks and after the drugs were given for 4 weeks. Results: Compared with the group D, the contents of NO and t-PA activity in the group C decreased significantly (P＜0.01), but the activity of PAI increased significantly (P＜0.01). Compared with the group C, the contents of NO and t-PA activity in the group A and B increased significantly (P＜0.05), but the activity of PAI decreased significantly (P＜0.05), with no significant difference between the two treatment groups (P＞0.05). Conclusion: GFSC could increase the level of NO, protect endotheolial cells and improve fibrinolytic activity, which might be the mechanism of GFSC in curing GINFH.     

老年性腰椎间盘突出症的手术治疗

老年性腰椎间盘突出症是指60岁以上发病者．其发病率相对较低，在病理、临床表现、手术方式、围手术期处理等方面都有别于中、青年患者。我院1995年1月～2000年8月共手术治疗腰椎间盘突出症417例．其中老年性腰椎间盘突出症46例，占11．03％。现将资料完整并获得随访的41例报告如下。     

经氯硝柳胺浸泡后湖北钉螺脑神经节的超微结构变化

用透射电镜进一步观察了湖北钉离神经节的纤维鞘，神经节胞体区和神经纤维网的超微结构，并且在神经纤维网部位首先发现了两个典型突触，经氯硝柳胺浸泡后，钉螺脑神经节的超微结构发生改变，神经纤维，神经胶质细胞和神经细胞内的线粒体由变性至坏死，神经细胞内的的糖原有含量显著减少，神经纤维网也发生变化坏死，这为阐明氯硝柳胺的灭螺机制提供了有用的资料。     

急性心肌梗死的溶栓疗法(上)

溶栓疗法是80年代以来急性心肌梗死（AMI）治疗的一个划时代进展。10多年来的临床研究，特别是国内外一系列多中心研究，已使该疗法趋于成熟，积累了大量经验。溶栓疗法对早期恢复冠状动脉（冠脉）血流、挽救濒死心肌、缩小梗死范围起到积极的治疗作用，对降低病死率及改善预后有肯定疗效。据1996年7月太原召开的“AMI再灌注治疗研讨会”上的不完全统计，自1990年10月“温州会议”以来，国内148家医院用静脉溶栓治疗AMI7082例，急诊（直接）PTCA（经度经腔冠脉成形术）183例（“温州会议”前分别为780例和2例）。如果说“温州会议”前…     

洋地黄类药物的新制剂及其临床监测方法

洋地黄是迄今应用最广泛、有效、历时较久的一类强心甙,仍适用于治疗心率过快或心率正常的慢性心力衰竭,尤其适用于心房纤颤,尚不能被利尿剂,扩血管或新型强心甙所取代。但现有的各种洋地黄制剂的共同缺点是安全范围窄、治疗指数低、有效治疗量难于掌握,促使人们寻找新的制剂。     

母女情深:家中唯一50岁男人做了变性

老陈50岁了,以种田为生,最近他突然出现在医院里,提出要做变性手术!最让人意外的是,陪他去医院的,是他的女儿。老陈说,他的全家都支持他去变性,这家人怎么了?     

高血压药物治疗的若干新进展

高血压是最常见的心血管疾病之一，近年来其患病率有明显上升趋势［1］。我国1991年的调查显示，高血压患病率达118％，较1979年的7．73％增加了约30％.高血压是冠心病、脑卒中、心力衰竭、肾功能衰竭最主要的发病因素。然而，大规模人群防治研究显示，降低高血压人群的血压水平，可有效地控制心、脑血管病的发生率，并减少其死亡率。回顾高血压治疗的发展史，高血压的治疗随着对高血压认识的深入而不断发展。很长时间内降压被视为禁忌，1927年Brown大胆地提出高血压病人如不予降压，则会出现肾功能衰竭的新观点，并主张应积极采取降压治疗…     

老年全身麻醉患者血清ADP、S-100β蛋白及HIF-1α水平与术后认知功能障碍的相关性分析

目的探讨老年全身麻醉患者血清脂联素(ADP)、S-100β蛋白及缺氧诱导因子-1α(HIF-1α)水平与术后认知功能障碍(POCD)的相关性。方法选取南阳市中心医院2017年1月至2019年1月收治的159例接受手术治疗的老年患者,根据术后简易精神状态检查表(MMSE)评分分为POCD组(MMSE<27分,n=53)和非POCD组(MMSE≥27分,n=106),比较两组患者手术前后ADP、S-100β蛋白、HIF-1α水平变化,Pearson相关性分析MMSE评分与血清ADP、S-100β蛋白、HIF-1α水平的相关性,受试者操作特征(ROC)曲线分析血清ADP、S-100β蛋白、HIF-1α水平对老年全身麻醉POCD的预测价值。结果术后两组血清ADP水平和MMSE评分均明显降低,S-100β蛋白、HIF-1α水平明显提升,POCD组较非POCD组改变更明显(P<0.05);Pearson相关性分析显示,POCD组术后MMSE评分与血清ADP水平呈正相关,与S-100β蛋白、HIF-1α水平呈负相关(P<0.05);ROC曲线显示,ADP+S-100β蛋白+HIF-1α预测老年全身麻醉患者POCD的曲线下面积(AUC)、敏感度、特异度高于各指标单独预测。结论老年全身麻醉POCD患者血清ADP水平明显降低,S-100β蛋白和HIF-1α水平明显提升,与POCD发生密切相关,联合检测能提升POCD预测价值。     

IMMUNOLOGICAL STUDIES ON THROMBOANGIITIS OBLITERANS

Using humoral immunity (gamma-globulin 18 cases, IgG, IgA, IgM each 30 cases, CH50, C3, C4 each 29 cases and CIC 31 cases), cellular immunity (E-RFC 68 cases, As 30 cases, SmIg, SmIgG each 18 cases, IMIT 30 cases) and immunopathological manifestations (light microscope, fluorescence microscope, transmitted electron microscope each 7 cases) as indices, we studied the immunological changes of "progressing", "remittent" and "stabilized" groups of patients with thromboangiitis obliterans (TAO) in different stages. Humoral immunity indicated that gamma-globulin, immune complex and IgG were all increased; cellular immunity indicated that the rate of T cells and suppressor cells was declined, while that of B cells was elevated. Immunopathologically, under light microscope all the layers of involved vessels were infiltrated with neutrophils, lymphocytes and monocytes; under fluorescence and electron microscope, immune complexes were found in the involved vessel walls. Our preliminary results suggest that TAO is an autoimmune disease relevant to antigen-antibody complex.