全文获取类型
收费全文 | 92291篇 |
免费 | 9667篇 |
国内免费 | 7308篇 |
专业分类
耳鼻咽喉 | 903篇 |
儿科学 | 1194篇 |
妇产科学 | 946篇 |
基础医学 | 10176篇 |
口腔科学 | 1697篇 |
临床医学 | 12566篇 |
内科学 | 12189篇 |
皮肤病学 | 806篇 |
神经病学 | 4281篇 |
特种医学 | 3417篇 |
外国民族医学 | 53篇 |
外科学 | 8386篇 |
综合类 | 18400篇 |
现状与发展 | 17篇 |
一般理论 | 6篇 |
预防医学 | 7136篇 |
眼科学 | 2444篇 |
药学 | 10642篇 |
118篇 | |
中国医学 | 6350篇 |
肿瘤学 | 7539篇 |
出版年
2024年 | 175篇 |
2023年 | 1489篇 |
2022年 | 2710篇 |
2021年 | 4859篇 |
2020年 | 4141篇 |
2019年 | 3215篇 |
2018年 | 3362篇 |
2017年 | 3152篇 |
2016年 | 2956篇 |
2015年 | 4673篇 |
2014年 | 5463篇 |
2013年 | 4986篇 |
2012年 | 7328篇 |
2011年 | 7739篇 |
2010年 | 5189篇 |
2009年 | 4039篇 |
2008年 | 4891篇 |
2007年 | 4949篇 |
2006年 | 4855篇 |
2005年 | 4458篇 |
2004年 | 3171篇 |
2003年 | 3284篇 |
2002年 | 2778篇 |
2001年 | 2402篇 |
2000年 | 2131篇 |
1999年 | 2068篇 |
1998年 | 1392篇 |
1997年 | 1312篇 |
1996年 | 935篇 |
1995年 | 981篇 |
1994年 | 814篇 |
1993年 | 435篇 |
1992年 | 547篇 |
1991年 | 509篇 |
1990年 | 401篇 |
1989年 | 381篇 |
1988年 | 273篇 |
1987年 | 225篇 |
1986年 | 195篇 |
1985年 | 138篇 |
1984年 | 73篇 |
1983年 | 57篇 |
1982年 | 44篇 |
1981年 | 35篇 |
1980年 | 26篇 |
1979年 | 25篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有10000条查询结果,搜索用时 718 毫秒
91.
92.
Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed. 相似文献
94.
Xiaoqing Guo Ji-Eun Seo Xilin Li Nan Mei 《Journal of toxicology and environmental health. Part B, Critical reviews》2020,23(1):27-50
ABSTRACTGenotoxic compounds may be detoxified to non-genotoxic metabolites while many pro-carcinogens require metabolic activation to exert their genotoxicity in vivo. Standard genotoxicity assays were developed and utilized for risk assessment for over 40 years. Most of these assays are conducted in metabolically incompetent rodent or human cell lines. Deficient in normal metabolism and relying on exogenous metabolic activation systems, the current in vitro genotoxicity assays often have yielded high false positive rates, which trigger unnecessary and costly in vivo studies. Metabolically active cells such as hepatocytes have been recognized as a promising cell model in predicting genotoxicity of carcinogens in vivo. In recent years, significant advances in tissue culture and biological technologies provided new opportunities for using hepatocytes in genetic toxicology. This review encompasses published studies (both in vitro and in vivo) using hepatocytes for genotoxicity assessment. Findings from both standard and newly developed genotoxicity assays are summarized. Various liver cell models used for genotoxicity assessment are described, including the potential application of advanced liver cell models such as 3D spheroids, organoids, and engineered hepatocytes. An integrated strategy, that includes the use of human-based cells with enhanced biological relevance and throughput, and applying the quantitative analysis of data, may provide an approach for future genotoxicity risk assessment. 相似文献
95.
96.
Qian S Zhang Brian L Browning Sharon R Browning 《European journal of human genetics : EJHG》2015,23(5):672-677
We performed genome-wide tests for association between haplotype clusters and each of 9 metabolic traits in a cohort of 5402 Northern Finnish individuals genotyped for 330 000 single-nucleotide polymorphisms. The metabolic traits were body mass index, C-reactive protein, diastolic blood pressure, glucose, high-density lipoprotein (HDL), insulin, low-density lipoprotein (LDL), systolic blood pressure, and triglycerides. Haplotype clusters were determined using Beagle. There were LDL-associated clusters in the chromosome 4q13.3-q21.1 region containing the albumin (ALB) and platelet factor 4 (PF4) genes. This region has not been associated with LDL in previous genome-wide association studies. The most significant haplotype cluster in this region was associated with 0.488 mmol/l higher LDL (95% CI: 0.361–0.615 mmol/l, P-value: 6.4 × 10−14). We also observed three previously reported associations: Chromosome 16q13 with HDL, chromosome 1p32.3-p32.2 with LDL and chromosome 19q13.31-q13.32 with LDL. The chromosome 1 and chromosome 4 LDL associations do not reach genome-wide significance in single-marker analyses of these data, illustrating the power of haplotypic association testing. 相似文献
97.
98.
99.
目的探讨化浊解毒方治疗溃疡性结肠炎(UC)的治疗作用及机制。方法120例UC患者按照随机数字表法分为观察组、对照组各60例。观察组予中药化浊解毒方口服,每日1剂,早晚2次温服;对照组予美沙拉嗪肠溶片口服,1.0 g/次,3次/d。2组疗程均4周。对比2组治疗前后Geboes指数、结肠镜下黏膜表现、生活质量评分、疾病活动指数及血清炎性因子IL-8、IL-35水平,凝血指标血清FIB水平,统计治疗后1年内复发情况。结果治疗后,观察组Geboes指数、疾病活动指数及血清炎性因子IL-8水平、凝血指标血清FIB水平均较本组治疗前降低,生活质量评分、血清炎性因子IL-35水平升高(P<0.05);且观察组治疗后疾病活动指数及血清炎性因子IL-8水平、凝血指标血清FIB水平均低于对照组,生活质量评分、血清炎性因子IL-35水平均高于对照组(P<0.05)。与对照组相比,治疗组糜烂、溃疡改善不明显(P>0.05),充血水肿、颗粒样变等肠镜表现改善情况均优于对照组(P<0.05)。治疗结束1年观察组复发率为10.64%,对照组为23.53%,2组差异有统计学意义(P<0.05)。结论化浊解毒方能改善UC患者临床症状,修复肠黏膜病理损伤,降低复发率;其机制可能与调节血清炎性因子IL-8、IL-35和凝血因子FIB水平有关。 相似文献
100.