新疆地区不同民族人群心房颤动与血清尿酸水平的相关性研究

目的探讨新疆地区维吾尔族、汉族心房颤动(AF)患者心房颤动的发生与血清尿酸水平的关系。方法以维吾尔族、汉族心房颤动患者各100例作为病例组,以维吾尔族、汉族非心房颤动患者各100例作为对照组,记录各组患者的年龄、性别、尿酸水平,用药情况等。采用Logistic回归分析心房颤动发生的危险因素。结果维吾尔族、汉族病例组与对照组比较,年龄、低密度脂蛋白、总胆固醇、尿酸水平差异有统计学意义(P0.05),心房颤动组年龄、低密度脂蛋白、总胆固醇和尿酸均显著高于非心房颤动组。多因素Logistic回归分析结果发现,年龄(OR=1.114,95%CI=1.080~1.149,P0.01)、总胆固醇(OR=1.902,95%CI=1.434~2.522,P0.01)和尿酸(OR=1.023,95%CI=1.017~1.029,P0.01)是心房颤动的独立危险因素。结论在新疆地区维吾尔族和汉族人群中,血清尿酸可能是心房颤动的危险因素。     

Analysis of risk factors for different subtypes of acute coronary syndrome

AimsTo investigate the different risk factors among different subtypes of patients with acute coronary syndrome (ACS).MethodsA total of 296 patients who had ACS were retrospectively enrolled. Blood and echocardiographic indices were assessed within 24 hours after admission. Differences in risk factors and Gensini scores of coronary lesions among three groups were analyzed.ResultsUnivariate analysis of risk factors for ACS subtypes showed that age, and levels of fasting plasma glucose, amino-terminal pro-brain natriuretic peptide, and creatine kinase isoenzyme were significantly higher in patients with non-ST-segment elevation myocardial infarction (NSTEMI) than in those with unstable angina pectoris (UAP). Logistic multivariate regression analysis showed that amino-terminal pro-brain natriuretic peptide and the left ventricular ejection fraction (LVEF) were related to ACS subtypes. The left ventricular end-diastolic diameter was an independent risk factor for UAP and ST-segment elevation myocardial infarction (STEMI) subtypes. The severity of coronary stenosis was significantly higher in NSTEMI and STEMI than in UAP. Gensini scores in the STEMI group were positively correlated with D-dimer levels (r = 0.429) and negatively correlated with the LVEF (r = −0.602).ConclusionDifferent subtypes of ACS have different risk factors. Our findings may have important guiding significance for ACS subtype risk assessment and clinical treatment.     

心房颤动导管射频消融肺静脉电隔离前后的抗凝治疗

目的探讨心房颤动(简称房颤)导管射频消融肺静脉电隔离前后的抗凝治疗效果。方法对2006年3月～2009年4月108例经导管消融治疗房颤患者进行随访分析。患者术前行经食管心脏超声和/或螺旋CT心脏成像检查排除心房内血栓;对有高血压、糖尿病、短暂脑缺血或脑栓塞病史者或年龄>65岁的房颤患者术前华法林抗凝治疗1个月,术后华法林抗凝治疗3个月。结果 108例患者共接受肺静脉电隔离治疗116次(8例进行了第二次肺静脉电隔离术),隔离肺静脉348根。108例患者均未发生与手术相关的血栓栓塞事件。结论房颤患者在导管射频消融静脉电隔离手术前常规行经食管超声和/或螺旋CT检查排除心房血栓,并在手术前后及术中进行规范抗凝治疗,可有效预防手术相关血栓栓塞并发症。     

肉苁蓉总甙的抗脂质过氧化作用及抗辐射作用

肉苁蓉总甙(GCs)可明显增强小鼠红细胞SOD活性,降低血清MDA含量,提高肝、肾组织中DNA,RNA含量,能明显促进受60Co照射损伤后小鼠红细胞SOD活性及脾核酸含量的恢复,降低肝MDA含量,提示GCs对核酸的保护作用及辐射防护作用与其抗脂质过氧化作用密切相关。